{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:15:19Z","timestamp":1793391319388,"version":"4.5.0"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>De novo spinal infections are an increasing medical problem. The decision-making for surgical or nonsurgical treatment for de novo spinal infections is often a non\u2013evidence-based process and commonly a case-by-case decision by single physicians. A scoring system based on the latest evidence might help improve the decision-making process compared with other purely radiology-based scoring systems or the judgment of a single senior physician.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Patients older than 18 years with an infection of the spine who underwent nonsurgical or surgical treatment between 2019 and 2021 were identified. Clinical data for neurological status, pain, and existing comorbidities were gathered and transferred to an anonymous spreadsheet. Patients without an MR image and a CT scan of the affected spine region were excluded from the investigation. A multidisciplinary expert panel used the Spine Instability Neoplastic Score (SINS), Spinal Instability Spondylodiscitis Score (SISS), and Spinal Infection Treatment Evaluation Score (SITE Score), previously developed by the authors\u2019 group, on every clinical case. Each physician of the expert panel gave an individual treatment recommendation for surgical or nonsurgical treatment for each patient. Treatment recommendations formed the expert panel opinion, which was used to calculate predictive validities for each score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 263 patients with spinal infections were identified. After the exclusion of doubled patients, patients without de novo infections, or those without CT and MRI scans, 123 patients remained for the investigation. Overall, 70.70% of patients were treated surgically and 29.30% were treated nonoperatively. Intraclass correlation coefficients (ICCs) for the SITE Score, SINS, and SISS were 0.94 (95% CI 0.91\u20130.95, p &lt; 0.01), 0.65 (95% CI 0.91\u20130.83, p &lt; 0.01), and 0.80 (95% CI 0.91\u20130.89, p &lt; 0.01). In comparison with the expert panel decision, the SITE Score reached a sensitivity of 96.97% and a specificity of 81.90% for all included patients. For potentially unstable and unstable lesions, the SISS and the SINS yielded sensitivities of 84.42% and 64.07%, respectively, and specificities of 31.16% and 56.52%, respectively. The SITE Score showed higher overall sensitivity with 97.53% and a higher specificity for patients with epidural abscesses (75.00%) compared with potentially unstable and unstable lesions for the SINS and the SISS. The SITE Score showed a significantly higher agreement for the definitive treatment decision regarding the expert panel decision, compared with the decision by a single physician for patients with spondylodiscitis, discitis, or spinal osteomyelitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The SITE Score shows high sensitivity and specificity regarding the treatment recommendation by a multidisciplinary expert panel. The SITE Score shows higher predictive validity compared with radiology-based scoring systems or a single physician and demonstrates a high validity for patients with epidural abscesses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2024.2.spine23664","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:00:56Z","timestamp":1715983256000},"page":"273-282","source":"Crossref","is-referenced-by-count":11,"title":["Ongoing decision-making dilemma for treatment of de novo spinal infections: a comparison of the Spinal Infection Treatment Evaluation Score with the Spinal Instability Spondylodiscitis Score and Spine Instability Neoplastic Score"],"prefix":"10.3171","volume":"41","author":[{"given":"Jonathan","family":"Pluemer","sequence":"first","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"},{"name":"Seattle Science Foundation, Seattle, Washington;"},{"name":"Department of Trauma Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgeniy","family":"Freyvert","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"},{"name":"Seattle Science Foundation, Seattle, Washington;"},{"name":"Department of Neurosurgical Spine Surgery, Houston Methodist, Houston, Texas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Pratt","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"},{"name":"Seattle Science Foundation, Seattle, Washington;"},{"name":"Department of Neurosurgery, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periklis","family":"Godolias","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"},{"name":"Seattle Science Foundation, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamzah A.","family":"Al-Awadi","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell H.","family":"Young","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Abdul-Jabbar","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"},{"name":"Seattle Science Foundation, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Schildhauer","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens R.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"},{"name":"Seattle Science Foundation, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod J.","family":"Oskouian","sequence":"additional","affiliation":[{"name":"Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington;"},{"name":"Seattle Science Foundation, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Epidemiol Infect","first-page":"e227","article-title":"Large increase of vertebral osteomyelitis in France: a 2010\u20132019 cross-sectional study","volume":"149","author":"Conan Y","year":"2021","unstructured":"Conan Y, Laurent E, Belin Y,  Large increase of vertebral osteomyelitis in France: a 2010\u20132019 cross-sectional study. 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Global Spine J. 2023;13(5):1418\u20131428."},{"issue":"51-52","key":"b4","series-title":"Dtsch Arztebl Int","first-page":"875","article-title":"Spondylodiscitis: diagnosis and treatment options","volume":"114","author":"Herren C","year":"2017","unstructured":"Herren C, Jung N, Pishnamaz M, Breuninger M, Siewe J, Sobottke R. Spondylodiscitis: diagnosis and treatment options. Dtsch Arztebl Int. 2017;114(51-52):875\u2013882."},{"issue":"6","key":"b5","series-title":"J Orthop","first-page":"508","article-title":"Management of pyogenic spinal infection, review of literature","volume":"16","author":"Aljawadi A","year":"2019","unstructured":"Aljawadi A, Jahangir N, Jeelani A,  Management of pyogenic spinal infection, review of literature. 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