{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:16:54Z","timestamp":1791335814397,"version":"4.3.1"},"reference-count":74,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Children with cerebral palsy (CP) often experience medically refractory hypertonia, for which there are surgical therapies including neuromodulation and rhizotomy. Traditional surgical treatment for medically refractory mixed hypertonia or dystonia includes intrathecal baclofen pumps and selective dorsal rhizotomy. A nonselective lumbosacral ventral-dorsal rhizotomy (VDR; ventral and dorsal roots lesioned by 80%\u201390%) has the potential to address the limitations of traditional surgical options. The authors highlighted the institutional safety and efficacy of nonselective lumbosacral VDR for palliative tone management in nonambulatory patients with more severe CP.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n The authors performed a retrospective analysis of patients who had undergone lumbosacral VDR between 2022 and 2023. Demographic factors, clinical variables, and operative characteristics were collected. The primary outcomes of interest included tone control and quality of life improvement. Secondary outcome measures included, as a measure of safety, perioperative events such as paresthesias. Postoperative complications were also noted.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Fourteen patients (7 female) were included in the study. All patients had undergone a T12\u2013L2 osteoplastic laminoplasty and bilateral L1\u2013S1 VDR. Nine patients had quadriplegic mixed hypertonia, 4 had quadriplegic spasticity, and 1 had generalized secondary dystonia. Following VDR, there was a significant decrease in both lower-extremity modified Ashworth Scale (mAS) scores (mean difference [MD] \u22122.77 \u00b1 1.0, p < 0.001) and upper-extremity mAS scores (MD \u22120.71 \u00b1 0.76, p = 0.02), with an average follow-up of 3 months. In the patient with generalized dystonia, the lower-extremity Barry-Albright Dystonia Scale score decreased from 8 to 0, and the overall score decreased from 32 to 13. All parents noted increased ease in caregiving, particularly in terms of positioning, transfers, and changing. The mean daily enteral baclofen dose decreased from 47 mg preoperatively to 24.5 mg postoperatively (p < 0.001). Three patients developed wound dehiscence, 2 of whom had concurrent infections.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Lumbosacral VDR is safe, is effective for tone control, and can provide quality of life improvements in patients with medically refractory lower-limb mixed hypertonia. Lumbosacral VDR can be considered for palliative tone control in nonambulatory patients with more severe CP. Larger studies with longer follow-ups are necessary to further determine safety and long-term benefits in these patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2024.3.focus2472","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T05:42:34Z","timestamp":1717220554000},"page":"E9","source":"Crossref","is-referenced-by-count":9,"title":["Nonselective lumbosacral ventral-dorsal rhizotomy for the management of lower-limb hypertonia in nonambulatory children with cerebral palsy"],"prefix":"10.3171","volume":"56","author":[{"given":"Sunny","family":"Abdelmageed","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosurgery, Ann and Robert H. Lurie Children\u2019s Hospital, Chicago;"},{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalia","family":"Dalmage","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Mossner","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Trierweiler","sequence":"additional","affiliation":[{"name":"NuVasive Clinical Services, Columbia, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Krater","sequence":"additional","affiliation":[{"name":"Shirley Ryan AbilityLab, Chicago, Illinois"},{"name":"Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Raskin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Ann and Robert H. 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