{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:03:03Z","timestamp":1787025783966,"version":"build-2736575974"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Previous randomized controlled trials have reported a significantly higher occlusion rate of large and giant aneurysms when utilizing the Tubridge flow diverter (FD). In the present trial, the safety and efficacy of the Tubridge FD in treating unruptured internal carotid artery (ICA) or vertebral artery (VA) aneurysms were assessed in a real-world setting.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n The Intracranial Aneurysms Managed by Parent Artery Reconstruction Using Tubridge Flow Diverter (IMPACT) study is a prospective, multicenter, single-arm clinical trial assessing the efficacy of the Tubridge FD in the management of unruptured aneurysms located in the ICA or VA. The primary endpoint was the complete occlusion (Raymond-Roy class 1) rate at the 1-year follow-up. The secondary endpoints included the technical success rate, the successful occlusion rate of the aneurysm, which is the degree of aneurysm embolization scored as Raymond-Roy class 1 or 2, major (> 50%) in-stent stenosis, and incidence of disabling stroke or neurological death associated with the target aneurysms.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n This study included 14 interventional neuroradiology centers, with 200 patients and 240 aneurysms. According to angiographic core laboratory assessment, 205 (85.4%) aneurysms were located in the ICA, 34 (14.2%) in the VA, and 1 (0.4%) in the middle cerebral artery. Additionally, 189 (78.8%) aneurysms were small (< 10 mm). At the 12-month follow-up, the total occlusion rate was 79.0% (166\/210, 95% CI 72.91%\u201384.34%). Additionally, the occurrence of disabling stroke or neurological death related to the specified aneurysms was 1% (2\/200).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The 1-year results from the IMPACT trial affirm the safety record of use of the Tubridge FD in the treatment of intracranial aneurysms in real-world scenarios. These results reveal low morbidity and mortality rates of 3.5% and 1.5%, respectively. Furthermore, they provide evidence of the effectiveness of the Tubridge FD, as demonstrated by the complete occlusion achieved in 166 of 210 (79%) cases.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2024.3.jns232116","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T21:23:05Z","timestamp":1718400185000},"page":"1697-1704","source":"Crossref","is-referenced-by-count":12,"title":["Intracranial Aneurysms Managed by Parent Artery Reconstruction Using Tubridge Flow Diverter study: 1-year outcomes"],"prefix":"10.3171","volume":"141","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Lv","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Disease, Henan Provincial People\u2019s Hospital, Zhengzhou;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liquan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changren","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Sichuan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Jiangxi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jiangsu Province Hospital, Jiangsu;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Guangxi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzhi","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Disease, Zhujiang Hospital of Southern Medical University, Guangzhou;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital of Sichuan University, Sichuan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqing","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital Affiliated to Shanghai Jiao Tong University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurointervention, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Dai","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Huang","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongrong","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Disease, Henan Provincial People\u2019s Hospital, Zhengzhou;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"6","key":"b1","series-title":"Ann Neurol","first-page":"793","article-title":"Flow diversion for treatment of intracranial aneurysms: mechanism and implications","volume":"85","author":"Chua MMJ","year":"2019","unstructured":"Chua MMJ, Silveira L, Moore J, Pereira VM, Thomas AJ, Dmytriw AA. 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