{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:41:41Z","timestamp":1782178901489,"version":"3.54.5"},"reference-count":37,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The overall aim of this study was to demonstrate the potential benefit of a novel mixed-reality\u2013head-mounted display (MR-HMD) on the spatial orientation of surgeons.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>In a prospective clinical investigation, the authors applied for the first time a new multicamera navigation technology in an operating room setting that allowed them to directly compare MR-HMD navigation to standard monitor navigation. In the study, which included 14 patients with nonruptured middle cerebral artery aneurysms, the authors investigated how intuitively and effectively surgical instruments could be guided in 5 different visual navigation conditions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The authors demonstrate that multicamera tracking can be reliably integrated in a clinical setting (usability score 1.12 \u00b1 0.31). Moreover, the technology captures large volumes of the operating room, allowing the team to track and integrate different devices and instruments, including MR-HMDs. Directly comparing mixed-reality navigation to standard monitor navigation revealed a significantly improved intuition in mixed reality, leading to navigation times that were twice as fast (2.1\u00d7, p \u2264 0.01). Despite the enhanced speed, the same targeting accuracy (approximately 2.5 mm, freehand tool use) in comparison to monitor navigation could be observed. Intraoperative planning strategies with mixed reality clearly outperformed classic preoperative planning: surgeons scored the mixed-reality plan as the best trajectory in 63% of the cases (chance level 33%).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The incorporation of mixed reality in neurosurgical operations marks a significant advancement in the field. The use of mixed reality in brain surgery enhances the spatial awareness of surgeons, enabling more instinctive and precise surgical interventions. This technological integration promises to refine the execution of complex procedures without compromising accuracy.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.3.jns24163","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T01:25:28Z","timestamp":1717809928000},"page":"1687-1696","source":"Crossref","is-referenced-by-count":8,"title":["Turning the operating room into a mixed-reality environment: a prospective clinical investigation for cerebral aneurysm clipping"],"prefix":"10.3171","volume":"141","author":[{"given":"Matthias","family":"Gmeiner","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Ring","sequence":"additional","affiliation":[{"name":"cortEXplore GmbH, Linz; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pr\u00fcckl","sequence":"additional","affiliation":[{"name":"cortEXplore GmbH, Linz; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth M.","family":"Lambrakis","sequence":"additional","affiliation":[{"name":"cortEXplore GmbH, Linz; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gollwitzer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Stefanits","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Stroh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sonnberger","sequence":"additional","affiliation":[{"name":"Institute for Neuroradiology, Kepler University Hospital, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracija","family":"Sardi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Aichholzer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kepler University Hospital, Linz;"},{"name":"Medical Faculty, Johannes Kepler University, Linz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schaffelhofer","sequence":"additional","affiliation":[{"name":"cortEXplore GmbH, Linz; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"World Neurosurg","first-page":"546","article-title":"Utility of neuronavigation in intracranial meningioma resection: a single-center retrospective study","volume":"90","author":"Bir SC","year":"2016","unstructured":"Bir SC, Konar SK, Maiti TK, Thakur JD, Guthikonda B, Nanda A. 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