{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:16:38Z","timestamp":1792512998884,"version":"4.5.0"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Stereo-electroencephalography (SEEG)\u2013guided radiofrequency thermocoagulation (RFTC) is being used incrementally in the invasive diagnosis of epilepsy. There is currently a lack of information regarding the potential cognitive consequences of the extended use of this technique. This work describes, for the first time, the cognitive outcomes after RFTC in patients with temporal lobe epilepsy (TLE), evaluated longitudinally and using a control group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Forty-eight adult patients with drug-resistant unilateral TLE (30 RFTC-treated patients and 18 controls) were evaluated using a comprehensive neuropsychological protocol at baseline. In the RFTC group, two follow-up assessments were performed at 3 months and 1 year. The control group was reevaluated after 1 year. Two analyses were performed: 1) group-level analyses, in which linear mixed models were applied according to TLE lateralization (intragroup and intergroup [RFTC vs control] comparisons), and 2) individual-level analyses, in which the Reliable Change Index (RCI) algorithm was developed and a 90% CI (cutoff \u00b1 1.64) was used to describe neuropsychological outcomes at 1 year post-RFTC. A memory subanalysis was performed in hippocampal RFTC patients (25\/30). A Spearman coefficient study was conducted to determine the correlation between cognitive change and thermocoagulated contacts.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Left- and right-sided TLE patients treated with RFTC showed cognitive preservation at baseline. At a group level, the short-term evaluation, including verbal and visual memory, language, and executive functions, showed preservation in these domains and no significant differences compared with baseline. In the long-term follow-up assessment (1 year after RFTC), no significant intragroup changes were found, nor were significant changes found in comparison with the control group. The RCI algorithm showed that significant individual cognitive losses and gains were infrequent. Three patients presented with naming deficits, only 1 (3.3%) of whom showed a clinically significant deficit. Significant gains were more prevalent in executive function tests with a speed component (4\/20 left-sided RFTC patients). Twenty-five of the 30 (83%) patients were treated with hippocampal RFTC. No patients experienced significant loss in verbal delayed memory in the left-sided RFTC sample or in visual delayed memory in the right-sided RFTC sample. The correlations between cognitive change and RFTC contacts were mostly nonsignificant.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>In the group-level comparisons, discernible cognitive impairment following RFTC was not evidenced. The majority of patients did not exhibit significant individual declines during the 1-year follow-up period. Notably, the procedural intervention yielded no substantial repercussions on memory functioning following hippocampal RFTC. These findings underscore the evidence supporting the cognitive preservation associated with SEEG-guided RFTC.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.4.jns232417","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T01:27:39Z","timestamp":1723858059000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Cognitive outcome after stereo-electroencephalography\u2013guided radiofrequency thermocoagulation in temporal lobe epilepsy"],"prefix":"10.3171","author":[{"given":"Carmen","family":"P\u00e9rez-Enr\u00edquez","sequence":"first","affiliation":[{"name":"Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar, Barcelona;"},{"name":"Epilepsy Unit, Department of Neurology, Hospital Vithas M\u00e1laga;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa","family":"Panad\u00e9s-de Oliveira","sequence":"additional","affiliation":[{"name":"Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar, Barcelona;"},{"name":"Epilepsy Neuroscience Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"Manero","sequence":"additional","affiliation":[{"name":"Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar, Barcelona;"},{"name":"Neurofunctionality and Language Group, Neurosciences Programme, Hospital del Mar Research Institute (IMIM), Barcelona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Pe\u00f1a-Casanova","sequence":"additional","affiliation":[{"name":"Neurofunctionality and Language Group, Neurosciences Programme, Hospital del Mar Research Institute (IMIM), Barcelona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Principe","sequence":"additional","affiliation":[{"name":"Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar, Barcelona;"},{"name":"Epilepsy Neuroscience Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona;"},{"name":"Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Barcelona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Zucca","sequence":"additional","affiliation":[{"name":"Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar, Barcelona;"},{"name":"Epilepsy Neuroscience Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Langohr","sequence":"additional","affiliation":[{"name":"Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona;"},{"name":"Department of Statistics and Operations Research, Universitat Polit\u00e8cnica de Catalunya, Barcelona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Conesa","sequence":"additional","affiliation":[{"name":"Epilepsy Neuroscience Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona;"},{"name":"Department of Neurosurgery, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazaret","family":"Infante","sequence":"additional","affiliation":[{"name":"Epilepsy Neuroscience Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona;"},{"name":"Department of Neurosurgery, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Rocamora","sequence":"additional","affiliation":[{"name":"Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar, Barcelona;"},{"name":"Epilepsy Neuroscience Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona;"},{"name":"Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Barcelona;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Epileptic Disord","first-page":"221","article-title":"Cognitive outcomes of different surgical approaches in temporal lobe epilepsy","volume":"15","author":"Helmstaedter C","year":"2013","unstructured":"Helmstaedter C. Cognitive outcomes of different surgical approaches in temporal lobe epilepsy. Epileptic Disord. 2013;15(3):221\u2013239."},{"key":"b2","series-title":"Seizure","first-page":"64","article-title":"Surgical techniques: stereoelectroencephalography-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC)","volume":"77","author":"Bourdillon P","year":"2020","unstructured":"Bourdillon P, Rheims S, Catenoix H,  Surgical techniques: stereoelectroencephalography-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC). Seizure. 2020;77:64\u201368."},{"issue":"1","key":"b3","series-title":"Neurophysiol Clin","first-page":"5","article-title":"French guidelines on stereoelectroencephalography (SEEG)","volume":"48","author":"Isnard J","year":"2018","unstructured":"Isnard J, Taussig D, Bartolomei F,  French guidelines on stereoelectroencephalography (SEEG). Neurophysiol Clin. 2018;48(1):5\u201313."},{"issue":"2","key":"b4","series-title":"Curr Opin Neurol","first-page":"207","article-title":"The cognitive costs, contraindications and complications of epilepsy surgery in adults","volume":"33","author":"Baxendale S","year":"2020","unstructured":"Baxendale S. The cognitive costs, contraindications and complications of epilepsy surgery in adults. Curr Opin Neurol. 2020;33(2):207\u2013212."},{"issue":"5","key":"b5","series-title":"Arch Clin Neuropsychol","first-page":"413","article-title":"Hippocampal adequacy versus functional reserve: predicting memory functions following temporal lobectomy","volume":"10","author":"Chelune GJ","year":"1995","unstructured":"Chelune GJ. Hippocampal adequacy versus functional reserve: predicting memory functions following temporal lobectomy. Arch Clin Neuropsychol. 1995;10(5):413\u2013432."},{"key":"b6","series-title":"Epilepsy Res","first-page":"161","article-title":"Neuropsychologist\u2019s (re-)view: resective versus ablative amygdalohippocampectomies","volume":"142","author":"Witt JA","year":"2018","unstructured":"Witt JA, Hoppe C, Helmstaedter C. Neuropsychologist\u2019s (re-)view: resective versus ablative amygdalohippocampectomies. Epilepsy Res. 2018;142:161\u2013166."},{"issue":"3","key":"b7","series-title":"Epileptic Disord","first-page":"221","article-title":"Indications and expectations for neuropsychological assessment in epilepsy surgery in children and adults","volume":"21","author":"Baxendale S","year":"2019","unstructured":"Baxendale S, Wilson SJ, Baker GA,  Indications and expectations for neuropsychological assessment in epilepsy surgery in children and adults. Epileptic Disord. 2019;21(3):221\u2013234."},{"issue":"2","key":"b8","series-title":"Curr Opin Neurol","first-page":"174","article-title":"Cognition in epilepsy: current clinical issues of interest","volume":"30","author":"Witt JA","year":"2017","unstructured":"Witt JA, Helmstaedter C. Cognition in epilepsy: current clinical issues of interest. Curr Opin Neurol. 2017;30(2):174\u2013179."},{"issue":"1","key":"b9","series-title":"Pract Neurol","first-page":"43","article-title":"Neuropsychological assessment in epilepsy","volume":"18","author":"Baxendale S","year":"2018","unstructured":"Baxendale S. Neuropsychological assessment in epilepsy. Pract Neurol. 2018;18(1):43\u201348."},{"issue":"7","key":"b10","series-title":"Clin Neuropsychol","first-page":"1117","article-title":"Practice effects: a unique cognitive variable","volume":"26","author":"Duff K","year":"2012","unstructured":"Duff K, Callister C, Dennett K, Tometich D. Practice effects: a unique cognitive variable. Clin Neuropsychol. 2012;26(7):1117\u20131127."},{"key":"b11","series-title":"Epilepsy Behav","first-page":"269","article-title":"Red flags in epilepsy surgery: identifying the patients who pay a high cognitive price for an unsuccessful surgical outcome","volume":"78","author":"Baxendale S","year":"2018","unstructured":"Baxendale S, Thompson P. Red flags in epilepsy surgery: identifying the patients who pay a high cognitive price for an unsuccessful surgical outcome. Epilepsy Behav. 2018;78:269\u2013272."},{"issue":"3","key":"b12","series-title":"J Neurosurg","first-page":"837","article-title":"Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with MRI-negative focal epilepsy","volume":"138","author":"Oliveira LP","year":"2022","unstructured":"Oliveira LP, P\u00e9rez-Enr\u00edquez C, Barguilla A,  Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with MRI-negative focal epilepsy. J Neurosurg. 2022;138(3):837\u2013846."},{"issue":"1","key":"b13","series-title":"Neuropsychologia","first-page":"97","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield RC","year":"1971","unstructured":"Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9(1):97\u2013113."},{"issue":"4","key":"b14","series-title":"Arch Clin Neuropsychol","first-page":"307","article-title":"Spanish Multicenter Normative Studies (NEURONORMA Project): methods and sample characteristics","volume":"24","author":"Pe\u00f1a-Casanova J","year":"2009","unstructured":"Pe\u00f1a-Casanova J, Blesa R, Aguilar M,  Spanish Multicenter Normative Studies (NEURONORMA Project): methods and sample characteristics. Arch Clin Neuropsychol. 2009;24(4):307\u2013319."},{"key":"b15","article-title":"Escala de Memoria Wechsler (WMS-III). Manual T\u00e9cnico","author":"Wechsler D","year":"2004","unstructured":"Wechsler D. Escala de Memoria Wechsler (WMS-III). Manual T\u00e9cnico. TEA Ediciones;2004."},{"issue":"5","key":"b16","series-title":"Neurologia (Engl Ed)","first-page":"353","article-title":"Development, equivalence study, and normative data of version B of the Spanish-language Free and Cued Selective Reminding Test","volume":"36","author":"Grau-Guinea L","year":"2021","unstructured":"Grau-Guinea L, P\u00e9rez Enr\u00edquez C, Garc\u00eda-Escobar G,  Development, equivalence study, and normative data of version B of the Spanish-language Free and Cued Selective Reminding Test. Neurologia (Engl Ed). 2021;36(5):353-360."},{"key":"b17","series-title":"Neurologia (Engl Ed)","article-title":"Spanish normative studies (NEURONORMA-Plus project): norms for the Wisconsin Card Sorting Test, the Modified Taylor Complex Figure, and the Ruff-Light Trail Learning Test","author":"P\u00e9rez-Enr\u00edquez C","unstructured":"P\u00e9rez-Enr\u00edquez C, Garc\u00eda-Escobar G, Florido-Santiago M,  Spanish normative studies (NEURONORMA-Plus project): norms for the Wisconsin Card Sorting Test, the Modified Taylor Complex Figure, and the Ruff-Light Trail Learning Test. Neurologia (Engl Ed). Published online September 20, 2021.doi:10.1016\/j.nrl.2021.05.017"},{"issue":"9","key":"b18","series-title":"J Neurol","first-page":"1998","article-title":"SEEG-guided radiofrequency coagulation (SEEG-guided RF-TC) versus anterior temporal lobectomy (ATL) in temporal lobe epilepsy","volume":"265","author":"Moles A","year":"2018","unstructured":"Moles A, Gu\u00e9not M, Rheims S,  SEEG-guided radiofrequency coagulation (SEEG-guided RF-TC) versus anterior temporal lobectomy (ATL) in temporal lobe epilepsy. J Neurol. 2018;265(9):1998\u20132004."},{"issue":"Pt A","key":"b19","series-title":"Epilepsy Behav","first-page":"106596","article-title":"Temporal lobe surgery and memory: lessons, risks, and opportunities","volume":"101","author":"Bauman K","year":"2019","unstructured":"Bauman K, Devinsky O, Liu AA. Temporal lobe surgery and memory: lessons, risks, and opportunities. Epilepsy Behav. 2019;101(Pt A):106596."},{"issue":"Pt 10","key":"b20","series-title":"Brain","first-page":"2772","article-title":"Brain regions underlying word finding difficulties in temporal lobe epilepsy","volume":"132","author":"Trebuchon-Da Fonseca A","year":"2009","unstructured":"Trebuchon-Da Fonseca A, Guedj E, Alario FX,  Brain regions underlying word finding difficulties in temporal lobe epilepsy. Brain. 2009;132(Pt 10):2772-2784."},{"key":"b21","series-title":"Epilepsy Behav","first-page":"61","article-title":"Temporal lobe epilepsy is associated with distinct cognitive phenotypes","volume":"96","author":"Elverman KH","year":"2019","unstructured":"Elverman KH, Resch ZJ, Quasney EE, Sabsevitz DS, Binder JR, Swanson SJ. Temporal lobe epilepsy is associated with distinct cognitive phenotypes. Epilepsy Behav. 2019;96:61\u201368."},{"issue":"5","key":"b22","series-title":"Epilepsia","first-page":"857","article-title":"Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates","volume":"52","author":"Sherman EMS","year":"2011","unstructured":"Sherman EMS, Wiebe S, Fay-McClymont TB,  Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia. 2011;52(5):857\u2013869."},{"issue":"5","key":"b23","series-title":"Seizure","first-page":"327","article-title":"Cognitive outcome after stereotactic amygdalohippocampectomy","volume":"21","author":"Vojt\u011bch Z","year":"2012","unstructured":"Vojt\u011bch Z, Kr\u00e1msk\u00e1 L, Mal\u00edkov\u00e1 H,  Cognitive outcome after stereotactic amygdalohippocampectomy. Seizure. 2012;21(5):327\u2013333."},{"issue":"12","key":"b24","series-title":"Epilepsia","first-page":"2143","article-title":"Verbal memory decline from hippocampal depth electrodes in temporal lobe surgery for epilepsy","volume":"58","author":"Ljung H","year":"2017","unstructured":"Ljung H, Nordlund A, Strandberg M, Bengzon J, K\u00e4ll\u00e9n K. Verbal memory decline from hippocampal depth electrodes in temporal lobe surgery for epilepsy. 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