{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:56:41Z","timestamp":1792828601687,"version":"4.5.0"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The cavernous sinus (CS) has 4 compartments: superior, inferior, posterior, and lateral. Among these, the lateral compartment is the most common location for residual tumor, given the risk of neurovascular injury. The authors\u2019 study aimed to delineate the anatomical landmarks in this area and illustrate the technical nuances of the lateral transcavernous approach.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Twenty-two colored silicone\u2013injected specimens were dissected via an endoscopic endonasal approach to the lateral compartment of the CS. The anatomical landmarks and the internal carotid artery (ICA) mobilization technique were investigated. Two illustrative cases are provided.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The lateral compartment of the CS is bounded by the carotid-oculomotor membrane (COM) and optic strut as the roof and the petrolingual ligament and lingual process as the floor. It is divided into 2 asymmetrical subcompartments: the upper, larger subcompartment, located superior to the abducens nerve, accommodates the lateral parasellar ligament (LPL), inferolateral trunk (ILT), and branches of the tentorial artery; and the lower, smaller subcompartment, inferior to the abducens nerve, accommodates only the sympathetic nerve branches as they join the abducens nerve. The LPL is a well-defined ligamentous band and was identified in 38 (86%) hemispheres with 2 distinct configurations: 1) robust LPL (59%), with highly compacted ligamentous bands tightly adherent to the ICA; and 2) dispersed LPL (27%), with less compaction and adherence to ICA. The main attachment of the LPL to the cavernous ICA was most commonly observed at the horizontal ICA segment (55%), followed by the anterior (18%) and posterior (14%) genua. The ILT, as the main vessel in the lateral compartment, was identified in 41 (93%) hemispheres and originated from the horizontal ICA segment (80%) or the anterior genu (14%), from either the lateral (52%) or inferior (41%) aspect of the cross-section of the ICA. In 64% of hemispheres, the LPL wrapped the ILT, abducens nerve, and sympathetic nerve to form a broad and firm neurovascular-ligamental complex. Transection of the LPL, ILT, and COM enables medial ICA mobilization and enhances access to the lateral compartment of the CS, potentially increasing the exposure width by 6 \u00b1 1 mm.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>This study provides valuable insights into the anatomical intricacies of the lateral compartment of the CS and underscores the potential benefits of the endoscopic endonasal lateral transcavernous approach. Further clinical applications are essential for validating these findings and optimizing surgical outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.4.jns232662","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T01:30:09Z","timestamp":1723253409000},"page":"1-13","source":"Crossref","is-referenced-by-count":9,"title":["Lateral compartment of the cavernous sinus from the endoscopic endonasal approach: anatomical considerations and surgical relevance to adenoma surgery"],"prefix":"10.3171","author":[{"given":"Yuanzhi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Stanford Hospital, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karam","family":"Asmaro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford Hospital, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford Hospital, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Vigo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford Hospital, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mohyeldin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, Irvine, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano Alberto","family":"Nunez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford Hospital, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron A.","family":"Cohen-Gadol","sequence":"additional","affiliation":[{"name":"The Neurosurgical Atlas, Carmel, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Fernandez-Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford Hospital, Stanford, California;"},{"name":"The Neurosurgical Atlas, Carmel, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"J Neurosurg","first-page":"393","article-title":"Complications after 1002 endoscopic endonasal approach procedures at a single center: lessons learned, 2010-2018","volume":"136","author":"Hardesty DA","year":"2021","unstructured":"Hardesty DA, Montaser A, Kreatsoulas D,  Complications after 1002 endoscopic endonasal approach procedures at a single center: lessons learned, 2010-2018. 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