{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:25:18Z","timestamp":1784715918935,"version":"3.55.0"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The aim of this study was to provide geographic comparisons of deep brain stimulation (DBS) procedures in Latin America with the US and Europe regarding primary indications, demographic information, clinical and device-related adverse events, technology used, and patient outcomes using the Medtronic Product Surveillance Registry data as of July 31, 2021.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Two thousand nine hundred twelve patients were enrolled in the registry (2782 received DBS and 1580 are currently active). Fourteen countries contributed 44,100 years of device experience to the registry. DBS centers in Latin America are located in Colombia (n = 3), Argentina (n = 1), Brazil (n = 1), and Mexico (n = 1). Fisher\u2019s exact test was used to compare the difference in proportions of categorical variables between regions. The Wilcoxon signed-rank test was used for the EQ-5D index score change from baseline to follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The most common indication for DBS was Parkinson\u2019s disease across all regions. In Latin America, dystonia was the second most common indication, compared to essential tremor in other regions. There was a striking finding with respect to age\u2014patients were an average of 10 years younger at DBS implantation in Latin America. This difference was most likely due to the greater number of patients with dystonia receiving the device implants. The intraoperative techniques were quite similar, showing the same level of quality and covering the main principles of the surgeries with some variations in the brand of frames, planning software, and microrecording systems. Rechargeable batteries were significantly more common in Latin America (72.37%) than in the US (6.44%) and Europe (9.9%). Staging of the DBS procedure differed, with only 11.84% in Latin America staging the procedure compared with 97.58% and 34.86% in the US and Europe, respectively. The EQ-5D score showed significant improvements in all regions during the first 6\u201312 months (p &lt; 0.0001). However, the 24-month follow-up only showed an improvement in the scale for Latin America (p &lt; 0.0001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>DBS was performed in Latin America with similar indications, techniques, and technology as in the US and Europe. Important differences were found, with Latin America implementing more regular use of rechargeable devices, including younger patients at the time of surgery, and showing more sustained quality of life improvements at 24 months of follow-up. The authors hypothesize that these disparities stem from differences in resources among regions. However, more studies are needed to standardize DBS practice across the world to improve patients\u2019 quality of life and provide high-quality care.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.4.jns23924","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T01:23:28Z","timestamp":1720833808000},"page":"1587-1594","source":"Crossref","is-referenced-by-count":9,"title":["Deep brain stimulation in Latin America in comparison with the US and Europe in a real-world population: indications, demographics, techniques, technology, and adverse events"],"prefix":"10.3171","volume":"141","author":[{"given":"Adriana Lucia","family":"Lopez Rios","sequence":"first","affiliation":[{"name":"Department of Functional and Stereotactic Neurological Surgery, Hospital San Vicente Fundacion, Rionegro, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabi\u00e1n","family":"Piedimonte","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, CENIT Foundation, Buenos Aires, Argentina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel J.","family":"Arango","sequence":"additional","affiliation":[{"name":"Department of Neurology and Abnormal Movements, Latin American Institute of Neurology and Nervous System (ILANS), Bogot\u00e1, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel J.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Clinics, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Arellano-Reynoso","sequence":"additional","affiliation":[{"name":"Neurological Center, ABC Medical Center, Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griselda","family":"Del Carmen C\u00e9sar","sequence":"additional","affiliation":[{"name":"Neurological Center, ABC Medical Center, Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Carmona","sequence":"additional","affiliation":[{"name":"Department of Functional and Stereotactic Neurological Surgery, Neurocenter, Pereira, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ciampi de Andrade","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Clinics, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"An\u00edbal Restrepo-Bravo","sequence":"additional","affiliation":[{"name":"Department of Physiology, CES University, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Miguel","family":"Gloria Escobar","sequence":"additional","affiliation":[{"name":"Department of Physiology, CES University, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[{"name":"Medtronic Post Approval Clinical Surveillance (PACS), Minneapolis, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Medtronic Post Approval Clinical Surveillance (PACS), Minneapolis, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Weaver","sequence":"additional","affiliation":[{"name":"Medtronic Post Approval Clinical Surveillance (PACS), Minneapolis, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Eur J Neurol","first-page":"434","article-title":"Potential indications for deep brain stimulation in neurological disorders: an evolving field","volume":"25","author":"Budman E","year":"2018","unstructured":"Budman E, Deeb W, Martinez-Ramirez D. 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