{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:57:18Z","timestamp":1755226638470,"version":"3.43.0"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Pseudocapsular resection is a well-recognized, useful approach to achieve endocrinological remission in functioning pituitary neuroendocrine tumors (PitNETs). However, its advantage in nonfunctioning PitNETs (NF-PitNETs) has not been established. This study aimed to clarify the contribution of pseudocapsular resection to the prevention of NF-PitNET recurrence in long-term follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>This retrospective study included 132 patients who underwent total tumor removal and were followed for more than 5 years after surgery. The patients were categorized into those who underwent total pseudocapsular resection (n = 67) and those who did not (n = 65). The nonpseudocapsule (nonpseudocap) resection group included patients who underwent partial pseudocapsular resection and those in whom the pseudocapsule was not resected, did not exist, or could not be identified during surgery. The main outcome measures were the tumor recurrence rate and site of recurrence.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>In the nonpseudocap resection group, 2 patients (3.1%) had tumor recurrence in the cavernous sinus and 5 (7.7%) had tumor recurrence in the pituitary fossa. In the pseudocapsule (pseudocap) resection group, only 2 patients (3.0%) had tumor recurrence in the cavernous sinus and 0 patients had tumor recurrence in the pituitary fossa. Tumor recurrence in the pituitary fossa was more likely to occur in the nonpseudocap resection group than in the pseudocap resection group (p = 0.0267). Multivariate regression analysis revealed that pseudocapsular resection was a significant factor for reducing the tumor recurrence rate in the pituitary fossa (p = 0.0107).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Pseudocapsular resection may reduce the rate of tumor recurrence and improve the management of NF-PitNETs in long-term follow-up.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.4.jns2432","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T01:26:54Z","timestamp":1722648414000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Pseudocapsular resection to prevent recurrence in nonfunctioning pituitary neuroendocrine tumors: a retrospective, single-center study with more than 5 years of follow-up"],"prefix":"10.3171","author":[{"given":"Yasuyuki","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyuki","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neuro-Endovascular Therapy, Hiroshima Prefectural Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Neurosurg Rev","first-page":"201","article-title":"Surgical removal of growth hormone-secreting pituitary adenomas with intensive microsurgical pseudocapsule resection results in complete remission of acromegaly","volume":"28","author":"Kawamata T","year":"2005","unstructured":"Kawamata T, Kubo O, Hori T. Surgical removal of growth hormone-secreting pituitary adenomas with intensive microsurgical pseudocapsule resection results in complete remission of acromegaly. Neurosurg Rev. 2005;28(3):201\u2013208."},{"key":"b2","series-title":"Front Endocrinol (Lausanne)","first-page":"1056327","article-title":"Pseudocapsule and pseudocapsule-based extracapsular resection in pituitary neuroendocrine tumors","volume":"13","author":"Wang XB","year":"2022","unstructured":"Wang XB, Han TY, Ma JG,  Pseudocapsule and pseudocapsule-based extracapsular resection in pituitary neuroendocrine tumors. Front Endocrinol (Lausanne). 2022;13:1056327."},{"key":"b3","series-title":"Clin Neurol Neurosurg","first-page":"106997","article-title":"Pseudocapsular resection in elderly patients with non-functioning pituitary adenoma","volume":"210","author":"Kinoshita Y","year":"2021","unstructured":"Kinoshita Y, Taguchi A, Tominaga A, Arita K, Yamasaki F. Pseudocapsular resection in elderly patients with non-functioning pituitary adenoma. Clin Neurol Neurosurg. 2021;210:106997."},{"key":"b4","series-title":"World Neurosurg","first-page":"430","article-title":"The surgical side effects of pseudocapsular resection in nonfunctioning pituitary adenomas","volume":"93","author":"Kinoshita Y","year":"2016","unstructured":"Kinoshita Y, Tominaga A, Usui S,  The surgical side effects of pseudocapsular resection in nonfunctioning pituitary adenomas. World Neurosurg. 2016;93:430\u2013435.e1."},{"issue":"4","key":"b5","series-title":"Neurosurgery","first-page":"610","article-title":"Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings","volume":"33","author":"Knosp E","year":"1993","unstructured":"Knosp E, Steiner E, Kitz K, Matula C. Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery. 1993;33(4):610\u2013618."},{"issue":"3 Suppl","key":"b6","series-title":"Neurosurgery","first-page":"ons62","article-title":"Tumor tissue identification in the pseudocapsule of pituitary adenoma: should the pseudocapsule be removed for total resection of pituitary adenoma?","volume":"64","author":"Lee EJ","year":"2009","unstructured":"Lee EJ, Ahn JY, Noh T, Kim SH, Kim TS, Kim SH. Tumor tissue identification in the pseudocapsule of pituitary adenoma: should the pseudocapsule be removed for total resection of pituitary adenoma? Neurosurgery. 2009;64(3 Suppl):ons62\u2013ons70."},{"issue":"3","key":"b7","series-title":"Neuro Oncol","first-page":"318","article-title":"Stereotactic radiosurgery for non-functioning pituitary adenomas: meta-analysis and International Stereotactic Radiosurgery Society practice opinion","volume":"22","author":"Kotecha R","year":"2020","unstructured":"Kotecha R, Sahgal A, Rubens M,  Stereotactic radiosurgery for non-functioning pituitary adenomas: meta-analysis and International Stereotactic Radiosurgery Society practice opinion. Neuro Oncol. 2020;22(3):318\u2013332."},{"issue":"4","key":"b8","series-title":"Neurosurgery","first-page":"E539","article-title":"Congress of Neurological Surgeons systematic review and evidence-based guideline for the management of patients with residual or recurrent nonfunctioning pituitary adenomas","volume":"79","author":"Sheehan J","year":"2016","unstructured":"Sheehan J, Lee CC, Bodach ME,  Congress of Neurological Surgeons systematic review and evidence-based guideline for the management of patients with residual or recurrent nonfunctioning pituitary adenomas. Neurosurgery. 2016;79(4):E539\u2013E540."},{"issue":"1","key":"b9","series-title":"Int J Radiat Oncol Biol Phys","first-page":"87","article-title":"Single- and multi-fraction stereotactic radiosurgery dose tolerances of the optic pathways","volume":"110","author":"Milano MT","year":"2021","unstructured":"Milano MT, Grimm J, Soltys SG,  Single- and multi-fraction stereotactic radiosurgery dose tolerances of the optic pathways. Int J Radiat Oncol Biol Phys. 2021;110(1):87\u201399."},{"issue":"Suppl 1","key":"b10","series-title":"J Neurosurg","first-page":"47","article-title":"Hypopituitarism after Gamma Knife surgery for postoperative nonfunctioning pituitary adenoma","volume":"129","author":"Oh JW","year":"2018","unstructured":"Oh JW, Sung KS, Moon JH,  Hypopituitarism after Gamma Knife surgery for postoperative nonfunctioning pituitary adenoma. J Neurosurg. 2018;129(Suppl 1):47-54."},{"issue":"4","key":"b11","series-title":"Neuro Oncol","first-page":"715","article-title":"Stereotactic radiosurgery for nonfunctioning pituitary tumor: a multicenter study of new pituitary hormone deficiency","volume":"26","author":"Dumot C","year":"2024","unstructured":"Dumot C, Mantziaris G, Dayawansa S,  Stereotactic radiosurgery for nonfunctioning pituitary tumor: a multicenter study of new pituitary hormone deficiency. Neuro Oncol. 2024;26(4):715\u2013723."},{"issue":"1","key":"b12","series-title":"J Neurooncol","first-page":"41","article-title":"Effect of distance from target on hypopituitarism after stereotactic radiosurgery for pituitary adenomas","volume":"158","author":"Ironside N","year":"2022","unstructured":"Ironside N, Snyder H, Xu Z,  Effect of distance from target on hypopituitarism after stereotactic radiosurgery for pituitary adenomas. J Neurooncol. 2022;158(1):41\u201350."}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/aop\/article-10.3171-2024.4.JNS2432\/article-10.3171-2024.4.JNS2432.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/aop\/article-10.3171-2024.4.JNS2432\/article-10.3171-2024.4.JNS2432.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/aop\/article-10.3171-2024.4.JNS2432\/article-10.3171-2024.4.JNS2432.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T01:27:23Z","timestamp":1735349243000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/aop\/article-10.3171-2024.4.JNS2432\/article-10.3171-2024.4.JNS2432.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":12,"URL":"https:\/\/doi.org\/10.3171\/2024.4.jns2432","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"type":"print","value":"0022-3085"},{"type":"electronic","value":"1933-0693"}],"subject":[],"published":{"date-parts":[[2024,8,1]]}}}