{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:06:41Z","timestamp":1778087201682,"version":"3.51.4"},"reference-count":47,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Hydrocephalic macrocephaly can result in poor psychosocial development, positioning difficulties, skin breakdown, and poor cosmesis. Although reduction cranioplasty can address these sequelae, the postoperative outcomes, complications, and mortality risk of reduction cranioplasty are not well understood given the rarity of hydrocephalic macrocephaly. Therefore, the primary objective of this systematic review was to evaluate the surgical outcomes of reduction cranioplasty for the treatment of hydrocephalic macrocephaly.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>A systematic review was performed using the PubMed, Scopus, and Web of Science databases while following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Two independent reviewers screened 350 studies; 27 studies reporting surgical outcomes on reduction cranioplasty for hydrocephalic macrocephaly met inclusion criteria. Data on study design, patient demographics, operative details, and surgical outcomes were collected.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>There were 65 reduction cranioplasties among the 27 included studies. Eighteen (66.7%) studies presented level V evidence, 7 (25.9%) presented level IV evidence, and 2 (7.4%) presented level III evidence. Following reduction cranioplasty, there was improvement in postoperative head positioning in 23 (85.2%) studies, improvement in postoperative cosmesis in 22 (81.5%) studies, and improvement in global postoperative neurological functioning in 20 (74.1%) studies. The median estimated blood loss was 633 mL (range 20\u20132600 mL). Shunt revisions were the most common complication, reported in 9 (47.4%) of the 19 studies assessing complications. Of the 65 patients, there was a mortality rate of 6.2% (n = 4).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The majority of the included studies reported improvement in head size, head positioning, cranial cosmesis, and global neurological functioning following reduction cranioplasty for hydrocephalic macrocephaly. However, the prevalence of lower-level evidence, risk of blood loss, complications, and mortality indicates the need for a serious discussion of surgical indication, an experienced team, and thorough perioperative planning to perform these complex surgeries.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.4.peds23486","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T02:20:30Z","timestamp":1719022830000},"page":"221-233","source":"Crossref","is-referenced-by-count":2,"title":["Reduction cranioplasty for hydrocephalic macrocephaly: a systematic review of surgical outcomes"],"prefix":"10.3171","volume":"34","author":[{"given":"Steven P.","family":"Moura","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;"},{"name":"Division of Plastic and Reconstructive Surgery, Boston University School of Medicine, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra D.","family":"Center","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manasa","family":"Kalluri","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Blum","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen C.","family":"Shaffrey","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinggang J.","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bermans J.","family":"Iskandar","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharine B.","family":"Garland","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Y.","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"6","key":"b1","series-title":"Plast Reconstr Surg","first-page":"1763","article-title":"Correction of hydrocephalic macrocephaly with total cranial vault remodeling and molding helmet therapy","volume":"125","author":"Kohan E","year":"2010","unstructured":"Kohan E, Jackson E, Heller J, Lazareff J, Bradley JP. 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