{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:56:57Z","timestamp":1780113417972,"version":"3.54.0"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Second cervical vertebrae (C2) fractures are a common traumatic spinal injury in the elderly population. Surgical fusion and nonoperative bracing are two primary treatments for cervical instability, but the former is often withheld in the elderly due to concerns for poor postoperative outcomes arising from patient frailty. This study sought to evaluate the in-hospital differences in mortality, outcomes, and discharge disposition in elderly patients with C2 fractures undergoing surgical intervention compared with conservative therapy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The National Trauma Data Bank was queried from 2017 to 2019 for all patients aged \u2265 65 years with C2 fractures undergoing either surgical stabilization or conservative therapy. Propensity score matching was performed using k-nearest neighbors with replacement based on patient demographics, comorbidities, insurance type, injury severity, and fracture type. Group differences were compared using Student t-tests and Pearson\u2019s chi-square tests with Benjamini-Hochberg multiple comparisons correction. Subgroup analyses were performed in the 65\u201374, 75\u201379, and 80+ year age subgroups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Six thousand forty-nine patients were identified, of whom 2156 underwent surgery and 3893 received conservative treatment. Following matching, the surgery group had significantly lower mortality rates (5.52% vs 9.6%, p &lt; 0.001), a longer mean hospital length of stay (LOS; 12.64 vs 7.49 days p &lt; 0.001), and slightly higher rates of several complications (&lt; 3% difference), as well as lower rates of discharge home (14.56% vs 23.52%, p &lt; 0.001) and to hospice (1.07% vs 2.09%, p = 0.02) and a higher rate of discharge to intermediate care (68.83% vs 48.28%, p &lt; 0.001). Similar trends in mortality and LOS were noted in all 3 subgroups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>In elderly patients with C2 fractures, surgical stabilization confers a small survival advantage with a slightly higher in-hospital complication rate compared to conservative therapy. The increased rate of discharge to rehabilitation may represent better long-term prognosis following surgery. The increased risk of short-term complications is present but relatively small, thus surgery should not be withheld in patients with good long-term prognosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.4.spine231131","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T01:50:19Z","timestamp":1720835419000},"page":"498-507","source":"Crossref","is-referenced-by-count":3,"title":["In-hospital outcomes following surgery versus conservative therapy in elderly patients with C2 fractures: a propensity score\u2013matched analysis"],"prefix":"10.3171","volume":"41","author":[{"given":"Sam H.","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Chicago Medical School, Rosalind Franklin University, North Chicago, Illinois; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Sadeh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zayed","family":"Almadidy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit I.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nauman S.","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Orlando Regional Medical Center, Orlando Health Neuroscience & Rehabilitation Institute, Orlando, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","article-title":"C2 fractures","author":"Menger RP","year":"2023","unstructured":"Menger RP, Viswanathan VK, Notarianni C. 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