{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:24:20Z","timestamp":1785795860748,"version":"3.56.0"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>This study was designed to identify predictive factors associated with substantial contralateral progression in adult patients with bilateral nonhemorrhagic moyamoya disease (MMD) who undergo revascularization surgery (RS) on one hemisphere.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors retrospectively analyzed 174 contralateral hemispheres of patients with bilateral nonhemorrhagic MMD (non-hMMD) who underwent RS on one side. The primary endpoint was defined as substantial contralateral progression requiring additional RS 6 months after the initial RS. The annual risk and predictive factors for contralateral progression were also analyzed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Of 174 patients included in the study, 57 (32.8%) experienced contralateral progression over a mean follow-up of 45.3 \u00b1 31.6 months (range 12\u2013196 months). The annual risk for contralateral progression after initial unilateral RS was 7.7% per person-year. Multivariable analysis revealed that age (HR 0.967, 95% CI 0.944\u20130.992; p = 0.009) and a BMI \u2265 25 (HR 1.946, 95% CI 1.126\u20133.362; p = 0.017) were significant predictors of contralateral progression. Specifically, the annual risk of contralateral progression was 12.1% in the higher BMI (\u2265 25) group and 4.0% in the lower BMI (&lt; 25) group per person-year.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The study revealed a 7.7% per person-year rate of contralateral progression in patients with bilateral non-hMMD following unilateral RS. Younger age and a BMI \u2265 25 were identified as significant risk factors. For these patients, careful weight management and the use of antilipid agents may be crucial strategies for reducing the risk of contralateral progression after unilateral RS.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.5.jns2411","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T01:36:54Z","timestamp":1725673014000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Prediction of contralateral progression in patients with bilateral nonhemorrhagic moyamoya disease following unilateral revascularization surgery"],"prefix":"10.3171","author":[{"given":"Chang Hwan","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Chung-ang University Gwangmyeong Hospital, Gwangmyeong-si;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Soo","family":"Byoun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chungnam University Sejong Hospital, Sejong-si, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Deok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Pil","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Seung","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O-Ki","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Wan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Un","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Arch Neurol","first-page":"288","article-title":"Cerebrovascular \"moyamoya\" disease: disease showing abnormal net-like vessels in base of brain","volume":"20","author":"Suzuki J","year":"1969","unstructured":"Suzuki J, Takaku A. 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