{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:03:28Z","timestamp":1791576208595,"version":"4.3.4"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Advances in surface architecture and technology have made interbody fusion devices more bioactive, with the hope of facilitating the fusion process more successfully. The advent of these increasingly bioactive implants may reduce reliance on more expensive biologics that have previously been used to achieve high fusion rates.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>A retrospective review of prospectively collected data (August 2018\u2013December 2019) was conducted of consecutively performed anterior lumbar interbody fusions in which an acid-etched, nanosurface-modulated, titanium interbody device packed only with corticocancellous allograft chips and local blood was used. Minimum follow-up was 1 year, and inclusion required available imaging and outcome metrics preoperatively and at 1 year. Fusion and subsidence were assessed via CT scans and\/or dynamic radiographs. Health-related quality-of-life measures (Oswestry Disability Index [ODI], visual analog scale [VAS] back\/leg) were collected pre- and postoperatively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>In total, 55 patients met inclusion criteria (1 year of follow-up, available imaging, and outcome metrics). A total of 69 lumbar levels were treated in these 55 patients. The mean age was 67 \u00b1 12.1 years, with 47% female patients. Roughly one-third (35%) had previous spine surgery, and approximately one-tenth (9.1%) had prior spinal fusion. A total of 20.6% were treated at multiple levels (mean levels per patient 1.2, minimum 1, maximum 3). The mean preoperative patient-reported outcomes were as follows: ODI 39.71 \u00b1 18.15, VAS back 6.49 \u00b1 2.19, and VAS leg 5.41 \u00b1 2.71. One year after surgery, the mean improvements in patient-reported outcomes (vs preoperative scores) were as follows: ODI \u221222.9 \u00b1 13.08 (p &lt; 0.001), VAS back \u22123.75 \u00b1 2.03 (p &lt; 0.001), VAS leg \u22123.73 \u00b1 2.32 (p &lt; 0.001). All levels achieved fusion at 1 year postoperatively based on CT scans (65\/69 levels) or dynamic radiographs (4\/69 levels, change in score &lt; 5% on flexion-extension radiographs). Four of the 65 levels were assigned to the grade 3 category according to a CT-based grading system, meaning cranial and caudal endplate bone apposition to the implant on both surfaces with no clear intervertebral bone connection through or around the implant. Sixty-one of 65 were found to have contiguous intervertebral bone bridging and thus were assigned to grade 1 (n = 54) or grade 2 (n = 7). Low-grade graft subsidence (Marchi grade 0 or I) occurred in 9 levels (13.0%) and high-grade subsidence (Marchi grade II or III) in 4 levels (5.8%). No patients required reoperation at the level of anterior lumbar interbody fusion and no radiographic or clinical evidence of pedicle screw loosening or failure was observed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The combination of advances in materials science and surface technology as demonstrated with a nanotechnology titanium cage resulted in the ability to obtain lumbar interbody fusion with allograft chips and local blood alone. Achieving high fusion rates with low-cost biologics\/allograft provides for an attractive pathway toward reducing the cost of reconstructive spine care, and a potential incremental benefit for healthcare economics.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.5.spine231323","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T01:58:08Z","timestamp":1724464688000},"page":"589-595","source":"Crossref","is-referenced-by-count":2,"title":["Can titanium surface technology reduce cost for biologics in anterior lumbar interbody fusion?"],"prefix":"10.3171","volume":"41","author":[{"given":"Cameron","family":"Shirazi","sequence":"first","affiliation":[{"name":"San Diego Spine Foundation, San Diego;"},{"name":"Scripps Clinic, San Diego; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Ochoa","sequence":"additional","affiliation":[{"name":"San Diego Spine Foundation, San Diego;"},{"name":"Scripps Clinic, San Diego; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Malone","sequence":"additional","affiliation":[{"name":"San Diego Spine Foundation, San Diego;"},{"name":"Scripps Clinic, San Diego; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Price","sequence":"additional","affiliation":[{"name":"San Diego Spine Foundation, San Diego;"},{"name":"Scripps Clinic, San Diego; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay I.","family":"Kumar","sequence":"additional","affiliation":[{"name":"San Diego Spine Foundation, San Diego;"},{"name":"Scripps Clinic, San Diego; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrooz A.","family":"Akbarnia","sequence":"additional","affiliation":[{"name":"San Diego Spine Foundation, San Diego;"},{"name":"University of California San Diego Medical Center, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Mundis","sequence":"additional","affiliation":[{"name":"San Diego Spine Foundation, San Diego;"},{"name":"Scripps Clinic, San Diego; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sing","sequence":"additional","affiliation":[{"name":"University of California San Diego Medical Center, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Eastlack","sequence":"additional","affiliation":[{"name":"San Diego Spine Foundation, San Diego;"},{"name":"Scripps Clinic, San Diego; and"},{"name":"University of California San Diego Medical Center, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"5","key":"b1","series-title":"Clin Spine Surg","first-page":"E226","article-title":"Trends in anterior lumbar interbody fusion in the United States: a MarketScan study from 2007 to 2014","volume":"33","author":"Varshneya K","year":"2020","unstructured":"Varshneya K, Medress ZA, Jensen M,  Trends in anterior lumbar interbody fusion in the United States: a MarketScan study from 2007 to 2014. 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Spine (Phila Pa 1976). 2014;39(6):491\u2013496."}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/41\/5\/article-p589.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/41\/5\/article-p589.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/41\/5\/article-p589.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T13:20:29Z","timestamp":1733491229000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/41\/5\/article-p589.xml"}},"subtitle":["Presented at the 2024 AANS\/CNS Joint Section on Disorders of the Spine and Peripheral Nerves"],"short-title":[],"issued":{"date-parts":[[2024,11,1]]},"references-count":20,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2024.5.spine231323","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,1]]}}}