{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:33:02Z","timestamp":1781123582355,"version":"3.54.1"},"reference-count":60,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>MR-guided focused ultrasound (MRgFUS) is an evolving technology with numerous present and potential applications in pediatric neurosurgery. The aim of this study was to describe the use of MRgFUS, technical challenges, complications, and lessons learned at a single children\u2019s hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective analysis was performed of a prospectively collected database of all pediatric patients undergoing investigational use of MRgFUS for treatment of various neurosurgical pathologies at Children\u2019s National Hospital. Treatment details, clinical workflow, and standard operating procedures are described. Patient demographics, procedure duration, and complications were obtained through a chart review of anesthesia and operative reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In total, 45 MRgFUS procedures were performed on 14 patients for treatment of diffuse intrinsic pontine glioma (n = 12), low-grade glioma (n = 1), or secondary dystonia (n = 1) between January 2022 and April 2024. The mean age at treatment was 9 (range 5\u201322) years, and 64% of the patients were male. With increased experience, the total anesthesia time, sonication time, and change in core body temperature during treatment all significantly decreased. Complications affected 4.4% of patients, including 1 case of scalp edema and 1 patient with a postprocedure epidural hematoma. Device malfunction requiring abortion of the procedure occurred in 1 case (2.2%). Technical challenges related to transducer malfunction and sonication errors occurred in 6.7% and 11.1% of cases, respectively, all overcome by subsequent user modifications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The authors describe the largest series on MRgFUS technical aspects in pediatric neurosurgery at a single institution, comprising 45 total treatments. This study emphasizes potential technical challenges and provides valuable insights into the nuances of its application in pediatric patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2024.6.focus24332","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T09:08:44Z","timestamp":1725181724000},"page":"E6","source":"Crossref","is-referenced-by-count":9,"title":["MR-guided focused ultrasound in pediatric neurosurgery: current insights, technical challenges, and lessons learned from 45 treatments at Children\u2019s National Hospital"],"prefix":"10.3171","volume":"57","author":[{"given":"Gregory F.","family":"Keating","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, Medstar Georgetown University Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsi M.","family":"Chesney","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, Medstar Georgetown University Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirali","family":"Patel","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, Medstar Georgetown University Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Kilburn","sequence":"additional","affiliation":[{"name":"Brain Tumor Institute, Children\u2019s National Hospital; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Brain Tumor Institute, Children\u2019s National Hospital; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Packer","sequence":"additional","affiliation":[{"name":"Brain Tumor Institute, Children\u2019s National Hospital; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitanya","family":"Challa","sequence":"additional","affiliation":[{"name":"Anesthesiology, Children\u2019s National Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick F.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Donoho","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Myseros","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chima","family":"Oluigbo","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Keating","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan R.","family":"Syed","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Department of Neurosurgery, George Washington University School of Medicine & Health Sciences, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"B1","series-title":"Am J Pathol","first-page":"637","article-title":"Histology of cerebral lesions produced by focused ultrasound","volume":"20","author":"Lynn JG","year":"1944","unstructured":"Lynn JG, Putnam TJ. 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