{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:02:27Z","timestamp":1788184947960,"version":"build-2803163510"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Establishing benchmarks for length of stay (LOS) may inform strategies to improve resource efficiency, decrease costs, and advance care quality. In this study, the authors characterize postoperative LOS in endoscopic skull base surgery (ESBS) and elucidate prolonging factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>A retrospective chart review was conducted at a tertiary academic center including consecutive adult patients who underwent intradural ESBS with intraoperative CSF leak during primary repair between July 2018 and March 2024. LOS, calculated as the time between the end of anesthesia until discharge from the hospital, comprised the primary outcome. Categorical and continuous independent study variables were assessed for univariate LOS association via the Mann-Whitney U-test and Kendall\u2019s tau-b correlation, respectively, and those with significant associations were included as multiple linear regression inputs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>One hundred sixty-three patients were included, with a median LOS of 4.0 (interquartile range [IQR] 2.8\u20135.8) days. LOS was significantly prolonged in high-flow (n = 82) compared with low-flow (n = 81) CSF leak cohorts (median 4.5 [IQR 3.9\u20136.5] vs 2.9 [IQR 2.1\u20134.7] days, p = 0.002). Defects involving the anterior cranial fossa (n = 16, median 4.6 [IQR 3.3\u20137.5)] days), suprasellar region (n = 94, median 4.4 [IQR 3.2\u20136.4] days), sella (n = 138, median 3.9 [IQR 2.8\u20135.8] days), or posterior cranial fossa (n = 17, median 4.5 [IQR 3.9\u20136.5] days) had variable LOSs. On multiple linear regression, after controlling for numerous patient, surgical, and postoperative factors, lesion diameter (B = 0.16, 95% CI 0.048\u20130.26), bone defect area (B = 0.008, 95% CI 0.001\u20130.014), anesthesia time (B = 0.015, 95% CI 0.004\u20130.026), bed rest length (B = 2.34, 95% CI 1.12\u20133.56), postoperative CSF leak (B = 11.06, 95% CI 4.11\u201318.01), postoperative meningitis (B = 11.79, 95% CI 4.83\u201318.74), postoperative stroke\/hemorrhage (B = 25.25, 95% CI 18.43\u201332.06), and postoperative pneumonia (B = 5.59, 95% CI 0.79\u201310.38) independently predicted overall prolonged LOS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>With healthcare utilization receiving increased attention, mitigating factors that extend LOS are important. Extent of surgery and certain postoperative complications may constitute key factors prolonging LOS following intradural ESBS with intraoperative CSF leak.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.6.jns232409","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T01:25:14Z","timestamp":1727486714000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Predictors of length of postoperative stay following endoscopic skull base surgery with intraoperative CSF leak"],"prefix":"10.3171","author":[{"given":"Jonathan C.","family":"Pang","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Hong","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelyn","family":"Frank","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey M.","family":"Roman","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinho","family":"Jung","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Abiri","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore V.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin F.","family":"Bitner","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank P. K.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Neurological Surgery, University of California, Irvine, Orange, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.","family":"Kuan","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery and"},{"name":"Neurological Surgery, University of California, Irvine, Orange, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Int Forum Allergy Rhinol","first-page":"174","article-title":"Endoscopic skull base surgery and its impact on sinonasal-related quality of life","volume":"2","author":"McCoul ED","year":"2012","unstructured":"McCoul ED, Anand VK, Bedrosian JC, Schwartz TH. Endoscopic skull base surgery and its impact on sinonasal-related quality of life. Int Forum Allergy Rhinol. 2012;2(2):174\u2013181."},{"issue":"3","key":"b2","series-title":"ANZ J Surg","first-page":"122","article-title":"Extended endoscopic endonasal skull base surgery: from the sella to the anterior and posterior cranial fossa","volume":"82","author":"Oostra A","year":"2012","unstructured":"Oostra A, van Furth W, Georgalas C. Extended endoscopic endonasal skull base surgery: from the sella to the anterior and posterior cranial fossa. ANZ J Surg. 2012;82(3):122\u2013130."},{"issue":"1","key":"b3","series-title":"Laryngoscope","first-page":"16","article-title":"Endoscopic surgery of the anterior skull base","volume":"115","author":"Casler JD","year":"2005","unstructured":"Casler JD, Doolittle AM, Mair EA. Endoscopic surgery of the anterior skull base. Laryngoscope. 2005;115(1):16\u201324."},{"issue":"3","key":"b4","series-title":"J Neurosurg","first-page":"816","article-title":"Endoscopic versus nonendoscopic surgery for resection of pituitary adenomas: a national database study","volume":"134","author":"Goshtasbi K","year":"2020","unstructured":"Goshtasbi K, Lehrich BM, Abouzari M,  Endoscopic versus nonendoscopic surgery for resection of pituitary adenomas: a national database study. J Neurosurg. 2020;134(3):816\u2013824."},{"issue":"1","key":"b5","series-title":"Int Forum Allergy Rhinol","first-page":"17","article-title":"Management of cerebrospinal fluid rhinorrhea: an evidence-based review with recommendations","volume":"6","author":"Oakley GM","year":"2016","unstructured":"Oakley GM, Orlandi RR, Woodworth BA, Batra PS, Alt JA. Management of cerebrospinal fluid rhinorrhea: an evidence-based review with recommendations. Int Forum Allergy Rhinol. 2016;6(1):17\u201324."},{"issue":"1","key":"b6","series-title":"Infect Control Hosp Epidemiol","first-page":"77","article-title":"One thousand endoscopic skull base surgical procedures demystifying the infection potential: incidence and description of postoperative meningitis and brain abscesses","volume":"32","author":"Kono Y","year":"2011","unstructured":"Kono Y, Prevedello DM, Snyderman CH,  One thousand endoscopic skull base surgical procedures demystifying the infection potential: incidence and description of postoperative meningitis and brain abscesses. Infect Control Hosp Epidemiol. 2011;32(1):77\u201383."},{"issue":"3","key":"b7","series-title":"J Neurosurg","first-page":"555","article-title":"Incidence, clinical manifestations, and course of water and electrolyte metabolism disturbances following transsphenoidal pituitary adenoma surgery: a prospective observational study","volume":"111","author":"Kristof RA","year":"2009","unstructured":"Kristof RA, Rother M, Neuloh G, Klingm\u00fcller D. Incidence, clinical manifestations, and course of water and electrolyte metabolism disturbances following transsphenoidal pituitary adenoma surgery: a prospective observational study. J Neurosurg. 2009;111(3):555\u2013562."},{"issue":"2","key":"b8","series-title":"J Neurol Surg B Skull Base","first-page":"117","article-title":"Diabetes insipidus following endoscopic transsphenoidal surgery for pituitary adenoma","volume":"79","author":"Ajlan AM","year":"2018","unstructured":"Ajlan AM, Abdulqader SB, Achrol AS,  Diabetes insipidus following endoscopic transsphenoidal surgery for pituitary adenoma. J Neurol Surg B Skull Base. 2018;79(2):117\u2013122."},{"issue":"1","key":"b9","series-title":"BMC Cancer","first-page":"100","article-title":"A comprehensive study of risk factors for post-operative pneumonia following resection of meningioma","volume":"19","author":"Zuo MR","year":"2019","unstructured":"Zuo MR, Liang RF, Li M,  A comprehensive study of risk factors for post-operative pneumonia following resection of meningioma. 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Oper Neurosurg (Hagerstown). 2007;60(4 Suppl 2):295\u2013304."},{"key":"b24","series-title":"J Clin Neurosci","first-page":"1","article-title":"Lumber drain morbidity in endonasal endoscopic skull base surgery","volume":"101","author":"Birkenbeuel JL","year":"2022","unstructured":"Birkenbeuel JL, Abiri A, Warner DC,  Lumber drain morbidity in endonasal endoscopic skull base surgery. J Clin Neurosci. 2022;101:1\u20138."},{"issue":"1","key":"b25","series-title":"Int Forum Allergy Rhinol","first-page":"42","article-title":"Postoperative protocols following endoscopic skull base surgery: an evidence-based review with recommendations","volume":"13","author":"Abiri A","year":"2023","unstructured":"Abiri A, Patel TR, Nguyen E,  Postoperative protocols following endoscopic skull base surgery: an evidence-based review with recommendations. 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Pituitary. 2021;24(2):284\u2013291."},{"issue":"2","key":"b28","series-title":"J Neurosurg","first-page":"405","article-title":"Routine postoperative fluid restriction to prevent syndrome of inappropriate antidiuretic hormone secretion after transsphenoidal resection of pituitary adenoma","volume":"136","author":"Snyder MH","year":"2021","unstructured":"Snyder MH, Asuzu DT, Shaver DE, Vance ML, Jane JA. Routine postoperative fluid restriction to prevent syndrome of inappropriate antidiuretic hormone secretion after transsphenoidal resection of pituitary adenoma. J Neurosurg. 2021;136(2):405\u2013412."},{"issue":"5","key":"b29","series-title":"J Neurosurg","first-page":"1337","article-title":"Evaluation of early postoperative day 1 discharge after endoscopic endonasal pituitary adenoma resection","volume":"136","author":"Yu S","year":"2021","unstructured":"Yu S, Taghvaei M, Collopy S,  Evaluation of early postoperative day 1 discharge after endoscopic endonasal pituitary adenoma resection. J Neurosurg. 2021;136(5):1337\u20131346."},{"issue":"6","key":"b30","series-title":"J Neurol Surg B Skull Base","first-page":"635","article-title":"Machine learning models for predicting postoperative outcomes following skull base meningioma surgery","volume":"83","author":"Jimenez AE","year":"2022","unstructured":"Jimenez AE, Porras JL, Azad TD,  Machine learning models for predicting postoperative outcomes following skull base meningioma surgery. J Neurol Surg B Skull Base. 2022;83(6):635\u2013645."},{"issue":"1","key":"b31","series-title":"Neurosurgery","first-page":"E60","article-title":"Length of stay beyond medical readiness in neurosurgical patients: a prospective analysis","volume":"85","author":"Linzey JR","year":"2019","unstructured":"Linzey JR, Kahn EN, Shlykov MA, Johnson KT, Sullivan K, Pandey AS. Length of stay beyond medical readiness in neurosurgical patients: a prospective analysis. Neurosurgery. 2019;85(1):E60\u2013E65."},{"issue":"3","key":"b32","series-title":"Am J Rhinol","first-page":"308","article-title":"Endoscopic surgery for malignant tumors of the sinonasal tract and adjacent skull base: a 10-year experience","volume":"22","author":"Nicolai P","year":"2008","unstructured":"Nicolai P, Battaglia P, Bignami M,  Endoscopic surgery for malignant tumors of the sinonasal tract and adjacent skull base: a 10-year experience. 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Rhinology. 2021;59(1):10\u201320."},{"issue":"2","key":"b35","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"81","article-title":"Incidence of hospital-acquired infection and length of hospital stay","volume":"12","author":"Tess BH","year":"1993","unstructured":"Tess BH, Glenister HM, Rodrigues LC, Wagner MB. Incidence of hospital-acquired infection and length of hospital stay. Eur J Clin Microbiol Infect Dis. 1993;12(2):81\u201386."},{"issue":"6","key":"b36","series-title":"Arch Intern Med","first-page":"809","article-title":"Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study","volume":"160","author":"Heit JA","year":"2000","unstructured":"Heit JA, Silverstein MD, Mohr DN, Petterson TM, O\u2019Fallon WM, Melton LJ III. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med. 2000;160(6):809\u2013815."},{"issue":"2","key":"b37","series-title":"Pituitary","first-page":"174","article-title":"Endoscopic endonasal approach for pituitary adenoma: surgical complications in 301 patients","volume":"14","author":"Gondim JA","year":"2011","unstructured":"Gondim JA, Almeida JPC, Albuquerque LAF,  Endoscopic endonasal approach for pituitary adenoma: surgical complications in 301 patients. Pituitary. 2011;14(2):174\u2013183."},{"issue":"9","key":"b38","series-title":"Arch Intern Med","first-page":"1005","article-title":"Length of hospital stay for treatment of deep venous thrombosis and the incidence of recurrent thromboembolism","volume":"158","author":"White RH","year":"1998","unstructured":"White RH, Zhou H, Romano PS. Length of hospital stay for treatment of deep venous thrombosis and the incidence of recurrent thromboembolism. 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