{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:42:36Z","timestamp":1772552556654,"version":"3.50.1"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>An understanding of the complex nomenclature and 3D spatial relations between the cortical and white matter components of the retrocommissural portion of the hippocampal formation is essential for a successful outcome when performing surgery in the mediobasal temporal region. The goal of this study was to clarify the nomenclature related to the retrocommissural portion of the hippocampal formation and to provide a detailed description of its topography and inner structure from a relevant surgical perspective. This description can serve as an anatomical reference for approaching lesions in the mediobasal temporal region.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Fiber microdissection was performed from the superolateral and inferior aspects on 20 previously frozen, formalin-fixed human brains. Three formalin-fixed plastinated brain specimens were then sectioned in the coronal, axial, and sagittal planes, and the relevant sections were studied.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Based on its relationship with the corpus callosum, the hippocampal formation is subdivided into precommissural, supracommissural, and retrocommissural sections. The retrocommissural portion of the hippocampal formation, a structure in the mediobasal temporal region, is a component of both the floor of the temporal horn and the medial surface of the cerebral hemisphere. It includes the hippocampus (Ammon\u2019s horn and the dentate gyrus), subiculum, and related white matter fibers. Step-by-step microdissection revealed the complex ventricular and cisternal relationships of the retrocommissural portion of the hippocampal formation in the mediobasal temporal region. This further allowed clear distinction of each component of this formation in order to understand their complex reciprocal relationships that comprise a unique internal architecture and external morphology.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The fiber microdissection technique provides a valuable perspective for understanding the complex structure and relations of the components of the retrocommissural portion of the hippocampal formation. This study clarifies and supplements the information presently available in the literature by offering an anatomical reference essential for differentiating the topographic diagnosis and safer surgical planning for any lesion within this formation or the mediobasal temporal region.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.6.jns232987","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T01:32:19Z","timestamp":1729301539000},"page":"1-14","source":"Crossref","is-referenced-by-count":2,"title":["Microsurgical anatomy and the inner architecture of the retrocommissural portion of the hippocampal formation demonstrated through fiber microdissection"],"prefix":"10.3171","author":[{"given":"Cristina","family":"Goga","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, T\u00fcrkiye;"},{"name":"Department of Orthopedic Surgery and Traumatology, Neurosurgery and Spinal Surgery Unit, HFR\u2014H\u00f4pital Fribourgeois, University of Fribourg, Switzerland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, T\u00fcrkiye;"},{"name":"Department of Neurosurgery, Clinical Neuroscience Centre, University Hospital Z\u00fcrich, University of Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U\u011fur","family":"T\u00fcre","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, T\u00fcrkiye;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"Pt 1","key":"b1","series-title":"J Anat Physiol","first-page":"23","article-title":"The relation of the fornix to the margin of the cerebral cortex","volume":"32","author":"Smith GE","year":"1897","unstructured":"Smith GE. The relation of the fornix to the margin of the cerebral cortex. J Anat Physiol. 1897;32(Pt 1):23\u201358."},{"key":"b2","article-title":"The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections with MRI","author":"Duvernoy HM","year":"2013","unstructured":"Duvernoy HM, Cattin F, Risold PY. The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections with MRI. 4th ed. Springer; 2013."},{"key":"b3","article-title":"An Illustrated Terminologia Neuroanatomica: A Concise Encyclopedia of Human Neuroanatomy","author":"ten Donkelaar HJ","year":"2018","unstructured":"ten Donkelaar HJ, Kachl\u00edk D, Tubbs RS. An Illustrated Terminologia Neuroanatomica: A Concise Encyclopedia of Human Neuroanatomy. 1st ed. Springer Cham; 2018."},{"key":"b4","article-title":"The Human Central Nervous System: A Synopsis and Atlas","author":"Nieuwenhuys R","year":"2008","unstructured":"Nieuwenhuys R, Voogd J, Van Huijzen C. The Human Central Nervous System: A Synopsis and Atlas. 4th ed. Steinkopff Heidelberg; 2008."},{"key":"b5","article-title":"The Human Nervous System","author":"Mai JK","year":"2012","unstructured":"Mai JK, Paxinos G, eds.. The Human Nervous System. 3rd ed. Academic Press; 2012."},{"issue":"3","key":"b6","series-title":"Neurosurgery","first-page":"549","article-title":"Microsurgical anatomy of the temporal lobe: part 1: mesial temporal lobe anatomy and its vascular relationships as applied to amygdalohippocampectomy","volume":"45","author":"Wen HT","year":"1999","unstructured":"Wen HT, Rhoton AL Jr, de Oliveira E,  Microsurgical anatomy of the temporal lobe: part 1: mesial temporal lobe anatomy and its vascular relationships as applied to amygdalohippocampectomy. Neurosurgery. 1999;45(3):549\u2013592."},{"key":"b7","series-title":"J Psychol Neurol","first-page":"113","article-title":"Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system","volume":"46","author":"Lorente De N\u00f3 R","year":"1934","unstructured":"Lorente De N\u00f3 R. Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system. J Psychol Neurol. 1934;46:113\u2013177."},{"issue":"1","key":"b8","series-title":"Arch Neuropsych","first-page":"218","article-title":"Sitz und Wesen der Krankheiten im Lichte der topistischen Hirnforschung und des Variierens der Tiere. Erster Teil. Befunde der topistischen Hirnforschung als Beitrag zur Lehre von Krankheitssitz","volume":"39","author":"Vogt C","year":"1938","unstructured":"Vogt C, Vogt O. Sitz und Wesen der Krankheiten im Lichte der topistischen Hirnforschung und des Variierens der Tiere. Erster Teil. Befunde der topistischen Hirnforschung als Beitrag zur Lehre von Krankheitssitz. Arch Neuropsych. 1938;39(1):218."},{"issue":"3","key":"b9","series-title":"Archiv f. Psychiatrie","first-page":"631","article-title":"Erkrankung des Ammonshorns als aetiologisches Moment der Epilepsie","volume":"10","author":"Sommer W","year":"1880","unstructured":"Sommer W. Erkrankung des Ammonshorns als aetiologisches Moment der Epilepsie. Archiv f. Psychiatrie. 1880;10(3):631\u2013675."},{"issue":"6","key":"b10","series-title":"Hippocampus","first-page":"712","article-title":"The CA2 hippocampal subfield in humans: a review","volume":"33","author":"Insausti R","year":"2023","unstructured":"Insausti R, Mu\u00f1oz-L\u00f3pez M, Insausti AM. The CA2 hippocampal subfield in humans: a review. Hippocampus. 2023;33(6):712\u2013729."},{"key":"b11","article-title":"Architectonics of Human Cerebral Fiber System","author":"Krieg WJS","year":"1973","unstructured":"Krieg WJS. Architectonics of Human Cerebral Fiber System. Brain Books; 1973."},{"issue":"Pt 3","key":"b12","series-title":"J Anat","first-page":"389","article-title":"The cytoarchitectonics of the human cerebral cortex","volume":"63","author":"von Economo CF","year":"1929","unstructured":"von Economo CF, Parker S. The cytoarchitectonics of the human cerebral cortex. J Anat. 1929;63(Pt 3):389."},{"key":"b13","series-title":"Williams & Wilkins","article-title":"An Atlas of the Basal Ganglia, Brain Stem and Spinal Cord: Based on Myelin-Stained Material","author":"Riley HA","year":"1943","unstructured":"Riley HA. An Atlas of the Basal Ganglia, Brain Stem and Spinal Cord: Based on Myelin-Stained Material. Williams & Wilkins; 1943."},{"issue":"3","key":"b14","series-title":"Radiology","first-page":"747","article-title":"Hippocampal formation and related structures of the limbic lobe: anatomic-MR correlation. Part I. Surface features and coronal sections","volume":"162","author":"Naidich TP","year":"1987","unstructured":"Naidich TP, Daniels DL, Haughton VM, Williams A, Pojunas K, Palacios E. Hippocampal formation and related structures of the limbic lobe: anatomic-MR correlation. Part I. Surface features and coronal sections. Radiology. 1987;162(3):747\u2013754."},{"key":"b15","article-title":"Principles of Behavioral and Cognitive Neurology","year":"2000","unstructured":"Mesulam MM, ed. Principles of Behavioral and Cognitive Neurology. 2nd ed. Oxford University Press; 2000."},{"issue":"3","key":"b16","series-title":"J Neuropsychiatry Clin Neurosci","first-page":"315","article-title":"The limbic system: an anatomic, phylogenetic, and clinical perspective","volume":"9","author":"Mega MS","year":"1997","unstructured":"Mega MS, Cummings JL, Salloway S, Malloy P. The limbic system: an anatomic, phylogenetic, and clinical perspective. J Neuropsychiatry Clin Neurosci. 1997;9(3):315\u2013330."},{"issue":"4","key":"b17","series-title":"J Neurosurg","first-page":"773","article-title":"The paramedian supracerebellar-transtentorial approach to the entire length of the mediobasal temporal region: an anatomical and clinical study","volume":"116","author":"T\u00fcre U","year":"2012","unstructured":"T\u00fcre U, Harput MV, Kaya AH,  The paramedian supracerebellar-transtentorial approach to the entire length of the mediobasal temporal region: an anatomical and clinical study. J Neurosurg. 2012;116(4):773\u2013791."},{"key":"b18","article-title":"Microneurosurgery. Microneurosurgery of CNS Tumors. Vol IVB.","author":"Ya\u015fargil MG","year":"1996","unstructured":"Ya\u015fargil MG. Microneurosurgery. Microneurosurgery of CNS Tumors. Vol IVB. 1st ed. Thieme; 1996."},{"key":"b19","article-title":"Die makroskopische Anatomie der Ammonsformation","author":"Klingler J","year":"1948","unstructured":"Klingler J. Die makroskopische Anatomie der Ammonsformation. Fretz; 1948."},{"key":"b20","article-title":"Terminologia Neuroanatomica. International Federation of Associations of Anatomists","unstructured":"Terminologia Neuroanatomica. International Federation of Associations of Anatomists. Accessed July 16, 2024. https:\/\/fipat.library.dal.ca\/tna\/"},{"key":"b21","series-title":"Schweiz Arch Neurol Psychiatr","first-page":"247","article-title":"Erleichterung der makroskopischen Pr\u00e4paration des Gehirns durch den Gefrierprozess","volume":"36","author":"Klingler J","year":"1935","unstructured":"Klingler J. Erleichterung der makroskopischen Pr\u00e4paration des Gehirns durch den Gefrierprozess. Schweiz Arch Neurol Psychiatr. 1935;36:247\u2013256."},{"key":"b22","article-title":"Atlas Cerebri Humani: The Inner Structure of the Brain Demonstrated on the Basis of Macroscopical Preparations","author":"Klingler J","year":"1956","unstructured":"Klingler J, Ludwig E. Atlas Cerebri Humani: The Inner Structure of the Brain Demonstrated on the Basis of Macroscopical Preparations. Basel S Karger; 1956."},{"issue":"2","key":"b23","series-title":"Neurosurgery","first-page":"417","article-title":"Fiber dissection technique: lateral aspect of the brain","volume":"47","author":"T\u00fcre U","year":"2000","unstructured":"T\u00fcre U, Ya\u015fargil MG, Friedman AH, Al-Mefty O. Fiber dissection technique: lateral aspect of the brain. Neurosurgery. 2000;47(2):417\u2013427."},{"key":"b24","article-title":"Heidelberg Plastination Folder: Collection of Technical Leaflets of Plastination","author":"von Hagens G","year":"1986","unstructured":"von Hagens G. Heidelberg Plastination Folder: Collection of Technical Leaflets of Plastination. 2nd English ed. Biodur Products; 1986."},{"key":"b25","article-title":"Microneurosurgery. CNS Tumors: Surgical Anatomy, Neuropathology, Neuroradiology, Neurophysiology, Clinical Considerations, Operability, Treatment Options Volume IVA","author":"Ya\u015fargil MG","year":"2013","unstructured":"Ya\u015fargil MG. Microneurosurgery. CNS Tumors: Surgical Anatomy, Neuropathology, Neuroradiology, Neurophysiology, Clinical Considerations, Operability, Treatment Options Volume IVA. Thieme; 2013."},{"key":"b26","article-title":"The Temporal Lobe and Limbic System","author":"Gloor P","year":"1997","unstructured":"Gloor P. The Temporal Lobe and Limbic System. Oxford University Press; 1997."},{"issue":"2","key":"b27","series-title":"Neurosurgery","first-page":"312","article-title":"The indusium griseum: anatomic study with potential application to callosotomy","volume":"73","author":"Tubbs RS","year":"2013","unstructured":"Tubbs RS, Prekupec M, Loukas M, Hattab EM, Cohen-Gadol AA. The indusium griseum: anatomic study with potential application to callosotomy. Neurosurgery. 2013;73(2):312\u2013316."},{"issue":"6","key":"b28","series-title":"J Neurosurg","first-page":"1253","article-title":"The anatomy of Meyer\u2019s loop revisited: changing the anatomical paradigm of the temporal loop based on evidence from fiber microdissection","volume":"122","author":"Goga C","year":"2015","unstructured":"Goga C, T\u00fcre U. The anatomy of Meyer\u2019s loop revisited: changing the anatomical paradigm of the temporal loop based on evidence from fiber microdissection. J Neurosurg. 2015;122(6):1253\u20131262."},{"key":"b29","series-title":"World Neurosurg","first-page":"438","article-title":"Topographic classification of the thalamus surfaces related to microneurosurgery: a white matter fiber microdissection study","volume":"97","author":"Serra C","year":"2017","unstructured":"Serra C, T\u00fcre U, Krayenb\u00fchl N, \u015eeng\u00fcl G, Ya\u015fargil DC, Ya\u015fargil MG. Topographic classification of the thalamus surfaces related to microneurosurgery: a white matter fiber microdissection study. World Neurosurg. 2017;97:438\u2013452."},{"issue":"3","key":"b30","series-title":"Oper Neurosurg (Hagerstown)","first-page":"311","article-title":"A white matter fiber microdissection study of the anterior perforated substance and the basal forebrain: a gateway to the basal ganglia?","volume":"17","author":"Serra C","year":"2019","unstructured":"Serra C, Akeret K, Maldaner N,  A white matter fiber microdissection study of the anterior perforated substance and the basal forebrain: a gateway to the basal ganglia? Oper Neurosurg (Hagerstown). 2019;17(3):311\u2013320."},{"key":"b31","series-title":"Adv Tech Stand Neurosurg","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-7091-7008-3_2","article-title":"Selective amygdalo-hippocampectomy. Operative anatomy and surgical technique","volume":"12","author":"Ya\u015fargil MG","year":"1985","unstructured":"Ya\u015fargil MG, Teddy PJ, Roth P. Selective amygdalo-hippocampectomy. Operative anatomy and surgical technique. Adv Tech Stand Neurosurg. 1985;12:93\u2013123."},{"key":"b32","article-title":"De Humano Foetu Liber Tertio Editus Ac Recognitus: Eiusdem Anatomicarum Observationum Liber Ac de Tumoribus Secundum Locos Affectos Liber","author":"Arantius JC","year":"1587","unstructured":"Arantius JC. De Humano Foetu Liber Tertio Editus Ac Recognitus: Eiusdem Anatomicarum Observationum Liber Ac de Tumoribus Secundum Locos Affectos Liber. Brechtanum; 1587."},{"issue":"3","key":"b33","series-title":"J Comp Neurol","first-page":"213","article-title":"The significance of the term Hippocampus","volume":"35","author":"Lewis FT","year":"1923","unstructured":"Lewis FT. The significance of the term Hippocampus. J Comp Neurol. 1923;35(3):213\u2013230."},{"key":"b34","series-title":"Pauli Junchi","article-title":"Anatomici summi Romanae archetypae tabulae anatomicae","author":"Eustachi B","year":"1783","unstructured":"Eustachi B. Anatomici summi Romanae archetypae tabulae anatomicae. Pauli Junchi; 1783."},{"key":"b35","series-title":"Comm Acad Sci Imp Petropolitanae","first-page":"112","article-title":"De sinibus cerebri","volume":"4","author":"Duvernoy JG","year":"1729","unstructured":"Duvernoy JG. De sinibus cerebri. Comm Acad Sci Imp Petropolitanae. 1729;4:112\u2013116."},{"issue":"2","key":"b36","series-title":"Oper Neurosurg (Hagerstown)","first-page":"258","article-title":"Surgical approaches to the temporal horn: an anatomic analysis of white matter tract interruption","volume":"13","author":"Kadri PAS","year":"2017","unstructured":"Kadri PAS, de Oliveira JG, Krayenb\u00fchl N,  Surgical approaches to the temporal horn: an anatomic analysis of white matter tract interruption. Oper Neurosurg (Hagerstown). 2017;13(2):258\u2013270."},{"issue":"6 Suppl 3","key":"b37","series-title":"Neurosurgery","first-page":"989","article-title":"Three-dimensional microsurgical and tractographic anatomy of the white matter of the human brain","volume":"62","author":"Fern\u00e1ndez-Miranda JC","year":"2008","unstructured":"Fern\u00e1ndez-Miranda JC, Rhoton AL Jr, \u00c1lvarez-Linera J, Kakizawa Y, Choi C, de Oliveira EP. Three-dimensional microsurgical and tractographic anatomy of the white matter of the human brain. Neurosurgery. 2008;62(6 Suppl 3):989\u20131028."},{"issue":"3","key":"b38","series-title":"J Neurosurg","first-page":"747","article-title":"Microvascular anatomy of the medial temporal region","volume":"137","author":"Xu Y","year":"2021","unstructured":"Xu Y, Mohyeldin A, Nunez MA,  Microvascular anatomy of the medial temporal region. J Neurosurg. 2021;137(3):747\u2013759."},{"issue":"2","key":"b39","series-title":"J Neurosurg","first-page":"256","article-title":"Microsurgical anatomy of the hippocampal arteries","volume":"79","author":"Erdem A","year":"1993","unstructured":"Erdem A, Ya\u015fargil G, Roth P. Microsurgical anatomy of the hippocampal arteries. J Neurosurg. 1993;79(2):256\u2013265."},{"issue":"6","key":"b40","series-title":"Neurosurgery","first-page":"805","article-title":"Microvascular anatomy of the uncus and the parahippocampal gyrus","volume":"29","author":"Marinkovi\u0107 SV","year":"1991","unstructured":"Marinkovi\u0107 SV, Milisavljevi\u0107 MM, Vuckovi\u0107 VD. Microvascular anatomy of the uncus and the parahippocampal gyrus. Neurosurgery. 1991;29(6):805\u2013814."},{"issue":"4","key":"b41","series-title":"AMA Arch Neurol Psychiatry","first-page":"491","article-title":"Surgical therapy of temporal lobe seizures","volume":"64","author":"Penfield W","year":"1950","unstructured":"Penfield W, Flanigin H. Surgical therapy of temporal lobe seizures. AMA Arch Neurol Psychiatry. 1950;64(4):491\u2013500."},{"issue":"6","key":"b42","series-title":"Surg Neurol","first-page":"445","article-title":"Selective amygdalohippocampectomy as a surgical treatment of mesiobasal limbic epilepsy","volume":"17","author":"Wieser HG","year":"1982","unstructured":"Wieser HG, Ya\u015fargil MG. Selective amygdalohippocampectomy as a surgical treatment of mesiobasal limbic epilepsy. Surg Neurol. 1982;17(6):445\u2013457."},{"key":"b43","article-title":"Selective amygdalohippocampectomy","author":"T\u00fcre U","year":"2019","unstructured":"T\u00fcre U, Kaya AH, Aktekin B, Bing\u00f6l CA. Selective amygdalohippocampectomy. In: \u00c7atatalpe O, Jallo CI, eds. Pediatric Epilepsy Surgery. 2nd ed. Thieme; 2019."},{"key":"b44","series-title":"Charles C Thomas;","first-page":"461","article-title":"The transventricular amygdala-hippocampectomy in temporal lobe epilepsy","author":"Niemeyer P","year":"1958","unstructured":"Niemeyer P. The transventricular amygdala-hippocampectomy in temporal lobe epilepsy. In: Baldwin M, Bailey P, eds. Temporal Lobe Epilepsy. Charles C Thomas; 1958:461-482."},{"issue":"4","key":"b45","series-title":"Ann Surg","first-page":"625","article-title":"Temporal lobe seizures and the technic of subtotal temporal lobectomy","volume":"136","author":"Penfield W","year":"1952","unstructured":"Penfield W, Baldwin M. Temporal lobe seizures and the technic of subtotal temporal lobectomy. 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