{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:00:11Z","timestamp":1781190011227,"version":"3.54.1"},"reference-count":50,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Endovascular treatment (EVT) is an effective treatment for patients with acute vertebrobasilar artery complex occlusion (VBAO). However, the benefit of bridging thrombolysis prior to EVT remains controversial. The purpose of the present study is to explore the best treatment strategy between bridging treatment (BT) and direct EVT in patients with acute VBAO.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Patients with acute VBAO who underwent EVT within 24 hours of estimated occlusion in a nationwide retrospective registry at 65 stroke centers in 15 provinces in China from December 2015 to June 2022 were retrospectively analyzed. The outcomes of the BT and direct EVT groups were compared using propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). The primary outcome was favorable functional outcome, defined as a 90-day modified Rankin Scale (mRS) score of 0\u20133. Secondary outcomes included 90-day functional independence (mRS score 0\u20132), mRS score shift, in-hospital mortality, successful reperfusion, and symptomatic intracranial hemorrhage (sICH). In addition, a meta-analysis integrating currently available evidence was performed to make a systematic comparison between the two treatment strategies.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n A total of 2353 patients were ultimately included; 447 of these patients received BT and 1906 received direct EVT. In both the original cohort and in the 1:1 PSM analysis, patients in the BT group had a significantly higher rate of favorable functional outcome (adjusted odds ratio [aOR] 1.41, 95% CI 1.14\u20131.76 for the original cohort and aOR 1.44, 95% CI 1.07\u20131.92 for 1:1 PSM). Regarding secondary outcomes, patients with BT had a significantly lower rate of in-hospital mortality (aOR 0.67, 95% CI 0.51\u20130.88 for the original cohort and aOR 0.69, 95% CI 0.48\u20130.99 for 1:1 PSM) and a shift toward better outcomes on the mRS (aOR 1.35, 95% CI 1.12\u20131.63 for the original cohort and aOR 1.31, 95% CI 1.03\u20131.69 for 1:1 PSM). However, there were no significant differences in functional independence, successful reperfusion, and sICH between the two groups. A meta-analysis, which included 22 studies involving 6579 patients, also revealed the superiority of BT over direct EVT on favorable functional outcome (OR 1.19, 95% CI 1.03\u20131.37, I\n 2<\/jats:sup>\n = 0.00%; p = 0.02).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n This matched-control study and meta-analysis suggest that compared with direct EVT, BT may be associated with better functional outcomes in patients with acute VBAO treated within 24 hours of estimated occlusion.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2024.8.jns24648","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T20:30:37Z","timestamp":1736541037000},"page":"1786-1793","source":"Crossref","is-referenced-by-count":0,"title":["Bridging thrombolysis versus direct endovascular treatment in acute vertebrobasilar artery complex occlusion"],"prefix":"10.3171","volume":"142","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuxi People\u2019s Hospital, Wuxi, Jiangsu;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"11","key":"b1","series-title":"Lancet Neurol","first-page":"1002","article-title":"Basilar artery occlusion","volume":"10","author":"Mattle HP","year":"2011","unstructured":"Mattle HP, Arnold M, Lindsberg PJ, Schonewille WJ, Schroth G. Basilar artery occlusion. Lancet Neurol. 2011;10(11):1002\u20131014."},{"issue":"15","key":"b2","series-title":"N Engl J Med","first-page":"1361","article-title":"Trial of endovascular treatment of acute basilar-artery occlusion","volume":"387","author":"Tao C","year":"2022","unstructured":"Tao C, Nogueira RG, Zhu Y, Trial of endovascular treatment of acute basilar-artery occlusion. N Engl J Med. 2022;387(15):1361\u20131372."},{"issue":"15","key":"b3","series-title":"N Engl J Med","first-page":"1373","article-title":"Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion","volume":"387","author":"Jovin TG","year":"2022","unstructured":"Jovin TG, Li C, Wu L, Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion. N Engl J Med. 2022;387(15):1373\u20131384."},{"issue":"2","key":"b4","series-title":"Lancet Neurol","first-page":"115","article-title":"Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial","volume":"19","author":"Liu X","year":"2020","unstructured":"Liu X, Dai Q, Ye R, Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurol. 2020;19(2):115\u2013122."},{"issue":"20","key":"b5","series-title":"N Engl J Med","first-page":"1910","article-title":"Endovascular therapy for stroke due to basilar-artery occlusion","volume":"384","author":"Langezaal LCM","year":"2021","unstructured":"Langezaal LCM, van der Hoeven EJRJ, Mont\u2019Alverne FJA, Endovascular therapy for stroke due to basilar-artery occlusion. N Engl J Med. 2021;384(20):1910\u20131920."},{"issue":"3","key":"b6","series-title":"JAMA","first-page":"244","article-title":"Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial","volume":"325","author":"Suzuki K","year":"2021","unstructured":"Suzuki K, Matsumaru Y, Takeuchi M, Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial. JAMA. 2021;325(3):244\u2013253."},{"issue":"20","key":"b7","series-title":"N Engl J Med","first-page":"1833","article-title":"A randomized trial of intravenous alteplase before endovascular treatment for stroke","volume":"385","author":"LeCouffe NE","year":"2021","unstructured":"LeCouffe NE, Kappelhof M, Treurniet KM, A randomized trial of intravenous alteplase before endovascular treatment for stroke. N Engl J Med. 2021;385(20):1833\u20131844."},{"issue":"21","key":"b8","series-title":"N Engl J Med","first-page":"1981","article-title":"Endovascular thrombectomy with or without intravenous alteplase in acute stroke","volume":"382","author":"Yang P","year":"2020","unstructured":"Yang P, Zhang Y, Zhang L, Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med. 2020;382(21):1981\u20131993."},{"issue":"3","key":"b9","series-title":"JAMA","first-page":"234","article-title":"Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT randomized clinical trial","volume":"325","author":"Zi W","year":"2021","unstructured":"Zi W, Qiu Z, Li F, Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT randomized clinical trial. JAMA. 2021;325(3):234\u2013243."},{"issue":"9","key":"b10","series-title":"J Neurol Neurosurg Psychiatry","first-page":"956","article-title":"Bridging versus direct endovascular therapy in basilar artery occlusion","volume":"92","author":"Nappini S","year":"2021","unstructured":"Nappini S, Arba F, Pracucci G, Bridging versus direct endovascular therapy in basilar artery occlusion. J Neurol Neurosurg Psychiatry. 2021;92(9):956\u2013962."},{"issue":"3","key":"b11","series-title":"Stroke Vasc Neurol","first-page":"190","article-title":"Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion","volume":"7","author":"Nie X","year":"2022","unstructured":"Nie X, Wang D, Pu Y, Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion. Stroke Vasc Neurol. 2022;7(3):190\u2013199."},{"issue":"1","key":"b12","series-title":"J Stroke","first-page":"128","article-title":"Bridging thrombolysis versus direct mechanical thrombectomy in stroke due to basilar artery occlusion","volume":"24","author":"Siow I","year":"2022","unstructured":"Siow I, Tan BYQ, Lee KS, Bridging thrombolysis versus direct mechanical thrombectomy in stroke due to basilar artery occlusion. J Stroke. 2022;24(1):128\u2013137."},{"issue":"10","key":"b13","series-title":"Neurol Sci","first-page":"5993","article-title":"Intravenous thrombolysis prior to endovascular treatment for acute ischemic stroke: a meta-analysis","volume":"43","author":"Zheng W","year":"2022","unstructured":"Zheng W, Lei H, Lin X, Intravenous thrombolysis prior to endovascular treatment for acute ischemic stroke: a meta-analysis. Neurol Sci. 2022;43(10):5993\u20136002."},{"issue":"11","key":"b14","series-title":"J Neurointerv Surg","first-page":"1101","article-title":"Temporal progression of functional independence after mechanical thrombectomy in acute vertebrobasilar artery occlusions","volume":"16","author":"Xu Y","year":"2024","unstructured":"Xu Y, Zhang P, Li W, Temporal progression of functional independence after mechanical thrombectomy in acute vertebrobasilar artery occlusions. J Neurointerv Surg. 2024;16(11):1101\u20131107."},{"issue":"5","key":"b15","series-title":"Transl Stroke Res","first-page":"916","article-title":"Effect of INR on outcomes of endovascular treatment for acute vertebrobasilar artery occlusion","volume":"15","author":"Xu Y","year":"2024","unstructured":"Xu Y, Huang Z, Zhang P, Effect of INR on outcomes of endovascular treatment for acute vertebrobasilar artery occlusion. Transl Stroke Res. 2024;15(5):916\u2013924."},{"issue":"5","key":"b16","series-title":"J Neurol","first-page":"767","article-title":"Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome","volume":"257","author":"Tei H","year":"2010","unstructured":"Tei H, Uchiyama S, Usui T, Ohara K. Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome. J Neurol. 2010;257(5):767\u2013773."},{"issue":"11","key":"b17","series-title":"J Neurointerv Surg","first-page":"1077","article-title":"Influence of renal impairment on clinical outcomes after endovascular recanalization in vertebrobasilar artery occlusions","volume":"14","author":"Xiao L","year":"2022","unstructured":"Xiao L, Gu M, Lu Y, Influence of renal impairment on clinical outcomes after endovascular recanalization in vertebrobasilar artery occlusions. J Neurointerv Surg. 2022;14(11):1077\u20131083."},{"issue":"7414","key":"b18","series-title":"BMJ","first-page":"557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins JP","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557\u2013560."},{"issue":"1","key":"b19","series-title":"JAMA Neurol","first-page":"25","article-title":"Effects of golden hour thrombolysis: a Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) substudy","volume":"72","author":"Ebinger M","year":"2015","unstructured":"Ebinger M, Kunz A, Wendt M, Effects of golden hour thrombolysis: a Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) substudy. JAMA Neurol. 2015;72(1):25\u201330."},{"issue":"3","key":"b20","series-title":"Ann Neurol","first-page":"596","article-title":"Thrombectomy with or without intravenous thrombolytics in basilar artery occlusion","volume":"94","author":"Ma\u00efer B","year":"2023","unstructured":"Ma\u00efer B, Finitsis S, Mazighi M, Thrombectomy with or without intravenous thrombolytics in basilar artery occlusion. Ann Neurol. 2023;94(3):596\u2013604."},{"issue":"8","key":"b21","series-title":"J Neurointerv Surg","first-page":"794","article-title":"Thrombectomy alone versus intravenous thrombolysis before thrombectomy for acute basilar artery occlusion","volume":"16","author":"Guo M","year":"2024","unstructured":"Guo M, Yue C, Yang J, Thrombectomy alone versus intravenous thrombolysis before thrombectomy for acute basilar artery occlusion. J Neurointerv Surg. 2024;16(8):794\u2013800."},{"issue":"12","key":"b22","series-title":"J Stroke Cerebrovasc Dis","first-page":"106847","article-title":"Endovascular thrombectomy with or without intravenous thrombolysis in acute basilar artery occlusion ischemic stroke: a meta-analysis","volume":"31","author":"Kohli GS","year":"2022","unstructured":"Kohli GS, Schartz D, Whyte R, Endovascular thrombectomy with or without intravenous thrombolysis in acute basilar artery occlusion ischemic stroke: a meta-analysis. J Stroke Cerebrovasc Dis. 2022;31(12):106847."},{"issue":"3-4","key":"b23","series-title":"Cerebrovasc Dis","first-page":"112","article-title":"Direct admission versus secondary transfer for acute stroke patients treated with intravenous thrombolysis and thrombectomy: insights from the endovascular treatment in ischemic stroke registry","volume":"47","author":"Weisenburger-Lile D","year":"2019","unstructured":"Weisenburger-Lile D, Blanc R, Kyheng M, Direct admission versus secondary transfer for acute stroke patients treated with intravenous thrombolysis and thrombectomy: insights from the endovascular treatment in ischemic stroke registry. Cerebrovasc Dis. 2019;47(3-4):112\u2013120."},{"issue":"12","key":"b24","series-title":"JAMA","first-page":"1279","article-title":"Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis","volume":"316","author":"Saver JL","year":"2016","unstructured":"Saver JL, Goyal M, van der Lugt A, Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA. 2016;316(12):1279\u20131288."},{"issue":"2","key":"b25","series-title":"JAMA Neurol","first-page":"190","article-title":"Time to reperfusion and treatment effect for acute ischemic stroke: a randomized clinical trial","volume":"73","author":"Fransen PS","year":"2016","unstructured":"Fransen PS, Berkhemer OA, Lingsma HF, Time to reperfusion and treatment effect for acute ischemic stroke: a randomized clinical trial. JAMA Neurol. 2016;73(2):190\u2013196."},{"issue":"11","key":"b1","series-title":"Lancet Neurol","first-page":"1002","article-title":"Basilar artery occlusion","volume":"10","author":"Mattle HP","year":"2011","unstructured":"Mattle HP, Arnold M, Lindsberg PJ, Schonewille WJ, Schroth G. Basilar artery occlusion. Lancet Neurol. 2011;10(11):1002\u20131014."},{"issue":"15","key":"b2","series-title":"N Engl J Med","first-page":"1361","article-title":"Trial of endovascular treatment of acute basilar-artery occlusion","volume":"387","author":"Tao C","year":"2022","unstructured":"Tao C, Nogueira RG, Zhu Y, Trial of endovascular treatment of acute basilar-artery occlusion. N Engl J Med. 2022;387(15):1361\u20131372."},{"issue":"15","key":"b3","series-title":"N Engl J Med","first-page":"1373","article-title":"Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion","volume":"387","author":"Jovin TG","year":"2022","unstructured":"Jovin TG, Li C, Wu L, Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion. N Engl J Med. 2022;387(15):1373\u20131384."},{"issue":"2","key":"b4","series-title":"Lancet Neurol","first-page":"115","article-title":"Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial","volume":"19","author":"Liu X","year":"2020","unstructured":"Liu X, Dai Q, Ye R, Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurol. 2020;19(2):115\u2013122."},{"issue":"20","key":"b5","series-title":"N Engl J Med","first-page":"1910","article-title":"Endovascular therapy for stroke due to basilar-artery occlusion","volume":"384","author":"Langezaal LCM","year":"2021","unstructured":"Langezaal LCM, van der Hoeven EJRJ, Mont\u2019Alverne FJA, Endovascular therapy for stroke due to basilar-artery occlusion. N Engl J Med. 2021;384(20):1910\u20131920."},{"issue":"3","key":"b6","series-title":"JAMA","first-page":"244","article-title":"Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial","volume":"325","author":"Suzuki K","year":"2021","unstructured":"Suzuki K, Matsumaru Y, Takeuchi M, Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial. JAMA. 2021;325(3):244\u2013253."},{"issue":"20","key":"b7","series-title":"N Engl J Med","first-page":"1833","article-title":"A randomized trial of intravenous alteplase before endovascular treatment for stroke","volume":"385","author":"LeCouffe NE","year":"2021","unstructured":"LeCouffe NE, Kappelhof M, Treurniet KM, A randomized trial of intravenous alteplase before endovascular treatment for stroke. N Engl J Med. 2021;385(20):1833\u20131844."},{"issue":"21","key":"b8","series-title":"N Engl J Med","first-page":"1981","article-title":"Endovascular thrombectomy with or without intravenous alteplase in acute stroke","volume":"382","author":"Yang P","year":"2020","unstructured":"Yang P, Zhang Y, Zhang L, Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med. 2020;382(21):1981\u20131993."},{"issue":"3","key":"b9","series-title":"JAMA","first-page":"234","article-title":"Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT randomized clinical trial","volume":"325","author":"Zi W","year":"2021","unstructured":"Zi W, Qiu Z, Li F, Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT randomized clinical trial. JAMA. 2021;325(3):234\u2013243."},{"issue":"9","key":"b10","series-title":"J Neurol Neurosurg Psychiatry","first-page":"956","article-title":"Bridging versus direct endovascular therapy in basilar artery occlusion","volume":"92","author":"Nappini S","year":"2021","unstructured":"Nappini S, Arba F, Pracucci G, Bridging versus direct endovascular therapy in basilar artery occlusion. J Neurol Neurosurg Psychiatry. 2021;92(9):956\u2013962."},{"issue":"3","key":"b11","series-title":"Stroke Vasc Neurol","first-page":"190","article-title":"Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion","volume":"7","author":"Nie X","year":"2022","unstructured":"Nie X, Wang D, Pu Y, Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion. Stroke Vasc Neurol. 2022;7(3):190\u2013199."},{"issue":"1","key":"b12","series-title":"J Stroke","first-page":"128","article-title":"Bridging thrombolysis versus direct mechanical thrombectomy in stroke due to basilar artery occlusion","volume":"24","author":"Siow I","year":"2022","unstructured":"Siow I, Tan BYQ, Lee KS, Bridging thrombolysis versus direct mechanical thrombectomy in stroke due to basilar artery occlusion. J Stroke. 2022;24(1):128\u2013137."},{"issue":"10","key":"b13","series-title":"Neurol Sci","first-page":"5993","article-title":"Intravenous thrombolysis prior to endovascular treatment for acute ischemic stroke: a meta-analysis","volume":"43","author":"Zheng W","year":"2022","unstructured":"Zheng W, Lei H, Lin X, Intravenous thrombolysis prior to endovascular treatment for acute ischemic stroke: a meta-analysis. Neurol Sci. 2022;43(10):5993\u20136002."},{"issue":"11","key":"b14","series-title":"J Neurointerv Surg","first-page":"1101","article-title":"Temporal progression of functional independence after mechanical thrombectomy in acute vertebrobasilar artery occlusions","volume":"16","author":"Xu Y","year":"2024","unstructured":"Xu Y, Zhang P, Li W, Temporal progression of functional independence after mechanical thrombectomy in acute vertebrobasilar artery occlusions. J Neurointerv Surg. 2024;16(11):1101\u20131107."},{"issue":"5","key":"b15","series-title":"Transl Stroke Res","first-page":"916","article-title":"Effect of INR on outcomes of endovascular treatment for acute vertebrobasilar artery occlusion","volume":"15","author":"Xu Y","year":"2024","unstructured":"Xu Y, Huang Z, Zhang P, Effect of INR on outcomes of endovascular treatment for acute vertebrobasilar artery occlusion. Transl Stroke Res. 2024;15(5):916\u2013924."},{"issue":"5","key":"b16","series-title":"J Neurol","first-page":"767","article-title":"Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome","volume":"257","author":"Tei H","year":"2010","unstructured":"Tei H, Uchiyama S, Usui T, Ohara K. Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome. J Neurol. 2010;257(5):767\u2013773."},{"issue":"11","key":"b17","series-title":"J Neurointerv Surg","first-page":"1077","article-title":"Influence of renal impairment on clinical outcomes after endovascular recanalization in vertebrobasilar artery occlusions","volume":"14","author":"Xiao L","year":"2022","unstructured":"Xiao L, Gu M, Lu Y, Influence of renal impairment on clinical outcomes after endovascular recanalization in vertebrobasilar artery occlusions. J Neurointerv Surg. 2022;14(11):1077\u20131083."},{"issue":"7414","key":"b18","series-title":"BMJ","first-page":"557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins JP","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557\u2013560."},{"issue":"1","key":"b19","series-title":"JAMA Neurol","first-page":"25","article-title":"Effects of golden hour thrombolysis: a Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) substudy","volume":"72","author":"Ebinger M","year":"2015","unstructured":"Ebinger M, Kunz A, Wendt M, Effects of golden hour thrombolysis: a Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) substudy. JAMA Neurol. 2015;72(1):25\u201330."},{"issue":"3","key":"b20","series-title":"Ann Neurol","first-page":"596","article-title":"Thrombectomy with or without intravenous thrombolytics in basilar artery occlusion","volume":"94","author":"Ma\u00efer B","year":"2023","unstructured":"Ma\u00efer B, Finitsis S, Mazighi M, Thrombectomy with or without intravenous thrombolytics in basilar artery occlusion. Ann Neurol. 2023;94(3):596\u2013604."},{"issue":"8","key":"b21","series-title":"J Neurointerv Surg","first-page":"794","article-title":"Thrombectomy alone versus intravenous thrombolysis before thrombectomy for acute basilar artery occlusion","volume":"16","author":"Guo M","year":"2024","unstructured":"Guo M, Yue C, Yang J, Thrombectomy alone versus intravenous thrombolysis before thrombectomy for acute basilar artery occlusion. J Neurointerv Surg. 2024;16(8):794\u2013800."},{"issue":"12","key":"b22","series-title":"J Stroke Cerebrovasc Dis","first-page":"106847","article-title":"Endovascular thrombectomy with or without intravenous thrombolysis in acute basilar artery occlusion ischemic stroke: a meta-analysis","volume":"31","author":"Kohli GS","year":"2022","unstructured":"Kohli GS, Schartz D, Whyte R, Endovascular thrombectomy with or without intravenous thrombolysis in acute basilar artery occlusion ischemic stroke: a meta-analysis. J Stroke Cerebrovasc Dis. 2022;31(12):106847."},{"issue":"3-4","key":"b23","series-title":"Cerebrovasc Dis","first-page":"112","article-title":"Direct admission versus secondary transfer for acute stroke patients treated with intravenous thrombolysis and thrombectomy: insights from the endovascular treatment in ischemic stroke registry","volume":"47","author":"Weisenburger-Lile D","year":"2019","unstructured":"Weisenburger-Lile D, Blanc R, Kyheng M, Direct admission versus secondary transfer for acute stroke patients treated with intravenous thrombolysis and thrombectomy: insights from the endovascular treatment in ischemic stroke registry. Cerebrovasc Dis. 2019;47(3-4):112\u2013120."},{"issue":"12","key":"b24","series-title":"JAMA","first-page":"1279","article-title":"Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis","volume":"316","author":"Saver JL","year":"2016","unstructured":"Saver JL, Goyal M, van der Lugt A, Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA. 2016;316(12):1279\u20131288."},{"issue":"2","key":"b25","series-title":"JAMA Neurol","first-page":"190","article-title":"Time to reperfusion and treatment effect for acute ischemic stroke: a randomized clinical trial","volume":"73","author":"Fransen PS","year":"2016","unstructured":"Fransen PS, Berkhemer OA, Lingsma HF, Time to reperfusion and treatment effect for acute ischemic stroke: a randomized clinical trial. 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