{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:36:30Z","timestamp":1792791390009,"version":"4.5.0"},"reference-count":140,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Patients with autosomal dominant polycystic kidney disease (ADPKD) have been identified to have a significantly increased risk of developing intracranial aneurysms (IAs). These patients are diagnosed at younger ages and are also at increased risk for IA rupture. The objective of this systematic review and meta-analysis was to identify risk factors associated with IA detection during screening of asymptomatic ADPKD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The authors searched for studies reporting the prevalence of IA among patients with ADPKD screened using MRA, CTA, or DSA on PubMed, Embase, Google Scholar, Scopus, Web of Science, Cochrane Database of Systematic Reviews, and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link>\n                      prior to August 2023 by using individualized standardized search strategies. Eligibility of all retrieved studies was assessed according to the PRISMA guidelines. Risk of bias of the included observational studies was assessed using the Newcastle-Ottawa Scale. Meta-analysis was performed using a random-effects model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twenty-four observational studies involving 5907 patients with ADPKD were identified for quantitative analysis. The authors observed an overall prevalence of IA of 12.6%. They identified several risk factors for IA with statistically significantly increased odds for unruptured IA (UIA) detection, including female sex (18 studies, OR 1.63, 95% CI 1.37\u20131.94, I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%), family history of either IA or subarachnoid hemorrhage (SAH) (12 studies, OR 2.17, 95% CI 1.68\u20132.81, I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%), family history of SAH (3 studies, OR 2.67, 95% CI 1.25\u20135.71, I\n                      <jats:sup>2<\/jats:sup>\n                      = 66.0%), stage 3 or greater chronic kidney disease (CKD) (4 studies, OR 2.55, 95% CI 1.84\u20133.54, I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%), and hypertension (13 studies, OR 1.41, 95% CI 1.04\u20131.91, I\n                      <jats:sup>2<\/jats:sup>\n                      = 34%). Age &gt; 45 years, family history of ADPKD, smoking status, and presence of liver cysts did not reach statistical significance as risk factors during this meta-analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The results of the authors\u2019 meta-analysis suggest increased risk of UIA detection in screening of ADPKD patients who are female, have a family history of IA or SAH, have hypertension, or have moderate or more severe CKD. Given the increased prevalence of IA in ADPKD patients with these risk factors, these patients may stand to benefit from screening for IA early in treatment or at time of diagnosis, even if neurologically asymptomatic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2024.9.jns241175","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T20:35:55Z","timestamp":1739565355000},"page":"220-231","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors for unruptured intracranial aneurysms in asymptomatic patients with autosomal dominant polycystic kidney disease: who needs screening? A systematic review and meta-analysis"],"prefix":"10.3171","volume":"143","author":[{"given":"Brandon A.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Scottsdale, Arizona;"},{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Precision Neuro-therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Halpin","sequence":"additional","affiliation":[{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Precision Neuro-therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Olson","sequence":"additional","affiliation":[{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Precision Neuro-therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillon","family":"Putzler","sequence":"additional","affiliation":[{"name":"John A. Burns School of Medicine, Honolulu, Hawaii;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Ghoche","sequence":"additional","affiliation":[{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Precision Neuro-therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Pach\u00f3n-Londo\u00f1o","sequence":"additional","affiliation":[{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Precision Neuro-therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn L.","family":"Turcotte","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Scottsdale, Arizona;"},{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Precision Neuro-therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Farzad","family":"Maroufi","sequence":"additional","affiliation":[{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Segovia","sequence":"additional","affiliation":[{"name":"Clinic Library, Mayo Clinic, Scottsdale, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi P.","family":"Patra","sequence":"additional","affiliation":[{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Precision Neuro-therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Departments of Neurological Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredric B.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence-Based Practice Center, Rochester, Minnesota; and"},{"name":"Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard R.","family":"Bendok","sequence":"additional","affiliation":[{"name":"Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Precision Neuro-therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, Arizona;"},{"name":"Departments of Neurological Surgery,"},{"name":"ENT\u2013Head & Neck Surgery, and"},{"name":"Radiology, Mayo Clinic, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"7","key":"b1","series-title":"Lancet Neurol","first-page":"626","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis","volume":"10","author":"Vlak MH","year":"2011","unstructured":"Vlak MH, Algra A, Brandenburg R, Rinkel GJ. 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