{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:01:12Z","timestamp":1785427272234,"version":"3.56.0"},"reference-count":90,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>During deep brain stimulation (DBS) surgery for Parkinson\u2019s disease (PD), intraoperative microelectrode recordings (MERs) are frequently used to determine electrode positioning within the subthalamic nucleus (STN) and globus pallidus internus (GPi). Various patient characteristics might be associated with abnormal STN and GPi firing activity and thus influence electrode placement. In this study, the authors aimed to elucidate the relationship between preoperative dopamine responsiveness or changes in cognitive status and STN or GPi multiunit activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients with PD undergoing awake STN (n = 74) or GPi (n = 63) DBS surgery with intraoperative MER at a single institution from 2013 to 2021. To control for the lead position, contralateral motor outcomes of each lead were graded using 1-year neurological follow-up notes. Multiunit neural firing activity for each lead was recorded from MER at the location corresponding to lead active contact at the 1-year follow-up assessment. Linear regression models, controlling for disease duration and age, were used to identify associations between multiunit neural firing rates and preoperative dopamine responsiveness, determined by the difference between preoperative motor scores when on medication minus preoperative motor scores when off medication, and between multiunit activity and the pre- to postoperative change in Mini-Mental State Examination scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Seventy-four patients with 130 STN leads (mean age 61.2 \u00b1 10.4 years) and 63 patients with 110 GPi leads (mean age 62.8 \u00b1 8.6 years) were included. In STN leads with maximum contralateral motor improvement, increased dopamine responsiveness was associated with both the intraoperative firing rate (p = 0.01) and disease duration (p = 0.01). These relationships were not significant in the GPi leads or when looking at leads for which patients experienced suboptimal motor improvement (p &gt; 0.05). In the GPi leads, an increased intraoperative firing rate in electrodes with maximum symptom improvement was associated with declining cognitive status (p = 0.045).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>These findings suggest patient characteristics that correlate with neural firing rates and influence intraoperative MER, final electrode placement, and patient outcomes, while improving understanding of STN and GPi pathophysiologic mechanisms in PD. Future investigations into other characteristics that might affect STN and GPi intraoperative neurophysiology are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.1.jns241414","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T21:54:27Z","timestamp":1748037267000},"page":"718-727","source":"Crossref","is-referenced-by-count":1,"title":["Intraoperative neural firing correlates with motor and cognitive features in Parkinson\u2019s disease"],"prefix":"10.3171","volume":"143","author":[{"given":"Natasha C.","family":"Hughes","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville;"},{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danika L.","family":"Paulo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zargari","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville;"},{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Doss","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville;"},{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saramati","family":"Narasimhan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"},{"name":"Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Shults","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"},{"name":"Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville;"},{"name":"Department of Electrical and Computer Engineering, Vanderbilt University, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit M.","family":"Dawant","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville;"},{"name":"Department of Electrical and Computer Engineering, Vanderbilt University, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaltra","family":"Dhima","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakmook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis J.","family":"Hassell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario J.","family":"Englot","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"},{"name":"Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville;"},{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Bick","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville;"},{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"6","key":"b1","series-title":"J Neurosurg","first-page":"1847","article-title":"Imaging alone versus microelectrode recording-guided targeting of the STN in patients with Parkinson\u2019s disease","volume":"130","author":"Lozano CS","year":"2018","unstructured":"Lozano CS, Ranjan M, Boutet A,  Imaging alone versus microelectrode recording-guided targeting of the STN in patients with Parkinson\u2019s disease. J Neurosurg. 2018;130(6):1847\u20131852."},{"issue":"1 Suppl","key":"b2","series-title":"Neurosurgery","first-page":"ONS96","article-title":"Experience with microelectrode guided subthalamic nucleus deep brain stimulation","volume":"58","author":"Amirnovin R","year":"2006","unstructured":"Amirnovin R, Williams ZM, Cosgrove GR, Eskandar EN. Experience with microelectrode guided subthalamic nucleus deep brain stimulation. Neurosurgery. 2006;58(1 Suppl):ONS96\u2013ONS102."},{"issue":"5","key":"b3","series-title":"Neuromodulation","first-page":"456","article-title":"Intraoperative microstimulation predicts outcome of postoperative macrostimulation in subthalamic nucleus deep brain stimulation for Parkinson\u2019s disease","volume":"20","author":"Mehanna R","year":"2017","unstructured":"Mehanna R, Machado AG, Connett JE, Alsaloum F, Cooper SE. Intraoperative microstimulation predicts outcome of postoperative macrostimulation in subthalamic nucleus deep brain stimulation for Parkinson\u2019s disease. Neuromodulation. 2017;20(5):456\u2013463."},{"issue":"3","key":"b4","series-title":"Med Image Anal","first-page":"744","article-title":"CranialVault and its CRAVE tools: a clinical computer assistance system for deep brain stimulation (DBS) therapy","volume":"16","author":"D\u2019Haese PF","year":"2012","unstructured":"D\u2019Haese PF, Pallavaram S, Li R,  CranialVault and its CRAVE tools: a clinical computer assistance system for deep brain stimulation (DBS) therapy. Med Image Anal. 2012;16(3):744\u2013753."},{"issue":"1","key":"b5","series-title":"J Neurol Neurosurg Psychiatry","first-page":"86","article-title":"Intraoperative physiology augments atlas-based data in awake deep brain stimulation","volume":"95","author":"Paulo DL","year":"2023","unstructured":"Paulo DL, Johnson GW, Doss DJ,  Intraoperative physiology augments atlas-based data in awake deep brain stimulation. J Neurol Neurosurg Psychiatry. 2023;95(1):86\u201396."},{"issue":"5","key":"b6","series-title":"J Neurophysiol","first-page":"2515","article-title":"Neuronal activity of the human subthalamic nucleus in the parkinsonian and nonparkinsonian state","volume":"100","author":"Steigerwald F","year":"2008","unstructured":"Steigerwald F, P\u00f6tter M, Herzog J,  Neuronal activity of the human subthalamic nucleus in the parkinsonian and nonparkinsonian state. J Neurophysiol. 2008;100(5):2515\u20132524."},{"issue":"1","key":"b7","series-title":"PLoS One","first-page":"e0244133","article-title":"Clinical outcome prediction from analysis of microelectrode recordings using deep learning in subthalamic deep brain stimulation for Parkinson\u2019s disease","volume":"16","author":"Park KH","year":"2021","unstructured":"Park KH, Sun S, Lim YH,  Clinical outcome prediction from analysis of microelectrode recordings using deep learning in subthalamic deep brain stimulation for Parkinson\u2019s disease. PLoS One. 2021;16(1):e0244133."},{"issue":"15","key":"b8","series-title":"Article in Chinese. Zhonghua Yi Xue Za Zhi","first-page":"1022","article-title":"Neuronal activity in the globus pallidus internus in parkinsonian patients with rigidity and bradykinesia","volume":"88","author":"Xu CP","year":"2008","unstructured":"Xu CP, Zhuang P, Li YJ. Neuronal activity in the globus pallidus internus in parkinsonian patients with rigidity and bradykinesia. Article in Chinese. Zhonghua Yi Xue Za Zhi. 2008;88(15):1022\u20131026."},{"issue":"15","key":"b9","series-title":"Article in Chinese. Zhonghua Yi Xue Za Zhi","first-page":"1021","article-title":"Neuronal activities in the ventrolateral thalamus and basal ganglia in relation to Parkinson\u2019s disease","volume":"86","author":"Wang J","year":"2006","unstructured":"Wang J, Zhuang P, Li YJ. Neuronal activities in the ventrolateral thalamus and basal ganglia in relation to Parkinson\u2019s disease. Article in Chinese. Zhonghua Yi Xue Za Zhi. 2006;86(15):1021\u20131026."},{"issue":"2","key":"b10","series-title":"Exp Neurol","first-page":"380","article-title":"Pathological synchronisation in the subthalamic nucleus of patients with Parkinson\u2019s disease relates to both bradykinesia and rigidity","volume":"215","author":"K\u00fchn AA","year":"2009","unstructured":"K\u00fchn AA, Tsui A, Aziz T,  Pathological synchronisation in the subthalamic nucleus of patients with Parkinson\u2019s disease relates to both bradykinesia and rigidity. Exp Neurol. 2009;215(2):380\u2013387."},{"issue":"1","key":"b11","series-title":"Exp Neurol","first-page":"108","article-title":"Local field potential beta activity in the subthalamic nucleus of patients with Parkinson\u2019s disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation","volume":"213","author":"Ray NJ","year":"2008","unstructured":"Ray NJ, Jenkinson N, Wang S,  Local field potential beta activity in the subthalamic nucleus of patients with Parkinson\u2019s disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Exp Neurol. 2008;213(1):108\u2013113."},{"issue":"14","key":"b12","series-title":"J Neurosci","first-page":"2859","article-title":"Parkinsonian beta dynamics during rest and movement in the dorsal pallidum and subthalamic nucleus","volume":"40","author":"Eisinger RS","year":"2020","unstructured":"Eisinger RS, Cagle JN, Opri E,  Parkinsonian beta dynamics during rest and movement in the dorsal pallidum and subthalamic nucleus. J Neurosci. 2020;40(14):2859\u20132867."},{"issue":"7","key":"b13","series-title":"Eur J Neurosci","first-page":"1956","article-title":"Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson\u2019s disease","volume":"23","author":"K\u00fchn AA","year":"2006","unstructured":"K\u00fchn AA, Kupsch A, Schneider GH, Brown P. Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson\u2019s disease. Eur J Neurosci. 2006;23(7):1956\u20131960."},{"issue":"Suppl 1","key":"b14","series-title":"Parkinsonism Relat Disord","first-page":"S44","article-title":"The functional role of beta oscillations in Parkinson\u2019s disease","volume":"20","author":"Little S","year":"2014","unstructured":"Little S, Brown P. The functional role of beta oscillations in Parkinson\u2019s disease. Parkinsonism Relat Disord. 2014;20(Suppl 1):S44\u2013S48."},{"issue":"3","key":"b15","series-title":"J Neurosci","first-page":"1033","article-title":"Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson\u2019s disease","volume":"21","author":"Brown P","year":"2001","unstructured":"Brown P, Oliviero A, Mazzone P, Insola A, Tonali P, Di Lazzaro V. Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson\u2019s disease. J Neurosci. 2001;21(3):1033\u20131038."},{"issue":"97","key":"b16","series-title":"Handb Clin Neurol","first-page":"105","article-title":"Deep brain stimulation for Parkinson\u2019s disease\u2014patient selection","volume":"116","author":"Pollak P","year":"2013","unstructured":"Pollak P. Deep brain stimulation for Parkinson\u2019s disease\u2014patient selection. Handb Clin Neurol. 2013;116(97):105."},{"issue":"2","key":"b17","series-title":"Mov Disord Clin Pract (Hoboken)","first-page":"140","article-title":"Preoperative levodopa response and deep brain stimulation effects on motor outcomes in Parkinson\u2019s disease: a systematic review","volume":"9","author":"Lin Z","year":"2021","unstructured":"Lin Z, Zhang C, Li D, Sun B. Preoperative levodopa response and deep brain stimulation effects on motor outcomes in Parkinson\u2019s disease: a systematic review. Mov Disord Clin Pract (Hoboken). 2021;9(2):140\u2013155."},{"issue":"6","key":"b18","series-title":"J Neurophysiol","first-page":"3248","article-title":"Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson\u2019s disease","volume":"96","author":"Weinberger M","year":"2006","unstructured":"Weinberger M, Mahant N, Hutchison WD,  Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson\u2019s disease. J Neurophysiol. 2006;96(6):3248\u20133256."},{"issue":"4","key":"b19","series-title":"J Parkinsons Dis","first-page":"1241","article-title":"Neurodegeneration of the globus pallidus internus as a neural correlate to dopa-response in freezing of gait","volume":"12","author":"Lench DH","year":"2022","unstructured":"Lench DH, Keith K, Wilson S,  Neurodegeneration of the globus pallidus internus as a neural correlate to dopa-response in freezing of gait. J Parkinsons Dis. 2022;12(4):1241\u20131250."},{"issue":"2","key":"b20","series-title":"Curr Opin Neurobiol","first-page":"157","article-title":"Sensory and cognitive functions of the basal ganglia","volume":"7","author":"Brown LL","year":"1997","unstructured":"Brown LL, Schneider JS, Lidsky TI. Sensory and cognitive functions of the basal ganglia. Curr Opin Neurobiol. 1997;7(2):157\u2013163."},{"issue":"59","key":"b21","series-title":"Int Rev Neurobiol","first-page":"97","article-title":"A general clinical overview of the non-motor symptoms in Parkinson\u2019s disease: neuropsychiatric symptoms","volume":"174","author":"Batzu L","year":"2024","unstructured":"Batzu L, Podlewska A, Gibson L, Chaudhuri KR, Aarsland D. A general clinical overview of the non-motor symptoms in Parkinson\u2019s disease: neuropsychiatric symptoms. Int Rev Neurobiol. 2024;174(59):97."},{"issue":"11","key":"b22","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1182","article-title":"Cognitive impairment in Parkinson\u2019s disease","volume":"78","author":"Verbaan D","year":"2007","unstructured":"Verbaan D, Marinus J, Visser M,  Cognitive impairment in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry. 2007;78(11):1182\u20131187."},{"issue":"1","key":"b23","series-title":"J Neurosurg","first-page":"230","article-title":"Electrode position and cognitive outcome following deep brain stimulation surgery","volume":"141","author":"Chen JW","year":"2024","unstructured":"Chen JW, Zargari M, Cole MW,  Electrode position and cognitive outcome following deep brain stimulation surgery. J Neurosurg. 2024;141(1):230\u2013240."},{"issue":"1","key":"b24","series-title":"JAMA","first-page":"63","article-title":"Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial","volume":"301","author":"Weaver FM","year":"2009","unstructured":"Weaver FM, Follett K, Stern M,  Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA. 2009;301(1):63\u201373."},{"issue":"8","key":"b25","series-title":"Lancet Neurol","first-page":"679","article-title":"Functional brain activity and presynaptic dopamine uptake in patients with Parkinson\u2019s disease and mild cognitive impairment: a cross-sectional study","volume":"11","author":"Ekman U","year":"2012","unstructured":"Ekman U, Eriksson J, Forsgren L, Mo SJ, Riklund K, Nyberg L. Functional brain activity and presynaptic dopamine uptake in patients with Parkinson\u2019s disease and mild cognitive impairment: a cross-sectional study. Lancet Neurol. 2012;11(8):679\u2013687."},{"issue":"Pt 6","key":"b26","series-title":"Brain","first-page":"1358","article-title":"Striatal and extrastriatal dysfunction in Parkinson\u2019s disease with dementia: a 6-[18F]fluoro-L-dopa PET study","volume":"125","author":"Ito K","year":"2002","unstructured":"Ito K, Nagano-Saito A, Kato T,  Striatal and extrastriatal dysfunction in Parkinson\u2019s disease with dementia: a 6-[18F]fluoro-L-dopa PET study. Brain. 2002;125(Pt 6):1358\u20131365."},{"issue":"9","key":"b27","series-title":"Brain","first-page":"3662","article-title":"Corticostriatal beta oscillation changes associated with cognitive function in Parkinson\u2019s disease","volume":"146","author":"Paulo DL","year":"2023","unstructured":"Paulo DL, Qian H, Subramanian D,  Corticostriatal beta oscillation changes associated with cognitive function in Parkinson\u2019s disease. Brain. 2023;146(9):3662\u20133675."},{"key":"b28","series-title":"Front Neuroanat","first-page":"139","article-title":"Extrastriatal dopaminergic circuits of the basal ganglia","volume":"4","author":"Rommelfanger KS","year":"2010","unstructured":"Rommelfanger KS, Wichmann T. Extrastriatal dopaminergic circuits of the basal ganglia. Front Neuroanat. 2010;4139."},{"issue":"3","key":"b29","series-title":"Neurotherapeutics","first-page":"485","article-title":"Neuromodulation for obsessive-compulsive disorder","volume":"11","author":"Lapidus KA","year":"2014","unstructured":"Lapidus KA, Stern ER, Berlin HA, Goodman WK. Neuromodulation for obsessive-compulsive disorder. Neurotherapeutics. 2014;11(3):485\u2013495."},{"issue":"3","key":"b30","series-title":"J Psychiatr Res","first-page":"189","article-title":"\"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein MF","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. \"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189\u2013198."},{"key":"b31","article-title":"Beck Depression Inventory\u2013II (BDI-II)","author":"Beck AT","year":"1996","unstructured":"Beck AT, Steer RA, Brown G. Beck Depression Inventory\u2013II (BDI-II). [Database record]. APA PsycTests;1996."},{"issue":"1","key":"b32","series-title":"Neurology","first-page":"55","article-title":"Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes","volume":"79","author":"Weaver FM","year":"2012","unstructured":"Weaver FM, Follett KA, Stern M,  Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes. Neurology. 2012;79(1):55\u201365."},{"issue":"1","key":"b33","series-title":"Mov Disord Clin Pract (Hoboken)","first-page":"24","article-title":"STN vs. GPi deep brain stimulation: translating the rematch into clinical practice","volume":"1","author":"Williams NR","year":"2014","unstructured":"Williams NR, Foote KD, Okun MS. STN vs. GPi deep brain stimulation: translating the rematch into clinical practice. Mov Disord Clin Pract (Hoboken). 2014;1(1):24\u201335."},{"issue":"559","key":"b34","series-title":"Neuroimage Clin","first-page":"571","article-title":"Beta-band oscillations in the supplementary motor cortex are modulated by levodopa and associated with functional activity in the basal ganglia","volume":"19","author":"Chung JW","year":"2018","unstructured":"Chung JW, Burciu RG, Ofori E,  Beta-band oscillations in the supplementary motor cortex are modulated by levodopa and associated with functional activity in the basal ganglia. Neuroimage Clin. 2018;19(559):571."},{"issue":"7","key":"b35","series-title":"J Parkinsons Dis","first-page":"2179","article-title":"Can dopamine responsiveness be predicted in Parkinson\u2019s disease without an acute administration test?","volume":"12","author":"Betrouni N","year":"2022","unstructured":"Betrouni N, Moreau C, Rolland AS,  Can dopamine responsiveness be predicted in Parkinson\u2019s disease without an acute administration test?. J Parkinsons Dis. 2022;12(7):2179\u20132190."},{"key":"b36","series-title":"Neuroscience","article-title":"Circuits within the basal ganglia system","author":"Purves D","year":"2001","unstructured":"Purves D, Augustine GJ, Fitzpatrick D, , eds. Circuits within the basal ganglia system. In: Neuroscience. 2nd ed. Sinauer Associates;2001.Accessed February 26, 2025. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK10847\/"},{"issue":"4","key":"b37","series-title":"Neuropsychol Rev","first-page":"439","article-title":"Cognition and depression following deep brain stimulation of the subthalamic nucleus and globus pallidus pars internus in Parkinson\u2019s disease: a meta-analysis","volume":"25","author":"Combs HL","year":"2015","unstructured":"Combs HL, Folley BS, Berry DTR,  Cognition and depression following deep brain stimulation of the subthalamic nucleus and globus pallidus pars internus in Parkinson\u2019s disease: a meta-analysis. Neuropsychol Rev. 2015;25(4):439\u2013454."},{"issue":"6","key":"b38","series-title":"PLoS One","first-page":"e0156721","article-title":"Cognitive and psychiatric effects of STN versus GPi deep brain stimulation in Parkinson\u2019s disease: a meta-analysis of randomized controlled trials","volume":"11","author":"Wang JW","year":"2016","unstructured":"Wang JW, Zhang YQ, Zhang XH, Wang YP, Li JP, Li YJ. Cognitive and psychiatric effects of STN versus GPi deep brain stimulation in Parkinson\u2019s disease: a meta-analysis of randomized controlled trials. PLoS One. 2016;11(6):e0156721."},{"issue":"1","key":"b39","series-title":"Neurol Ther","first-page":"7","article-title":"Globus pallidus internus (GPi) deep brain stimulation for Parkinson\u2019s disease: expert review and commentary","volume":"10","author":"Au KLK","year":"2021","unstructured":"Au KLK, Wong JK, Tsuboi T,  Globus pallidus internus (GPi) deep brain stimulation for Parkinson\u2019s disease: expert review and commentary. Neurol Ther. 2021;10(1):7\u201330."},{"issue":"5","key":"b40","series-title":"Exp Brain Res","first-page":"1455","article-title":"The cognitive role of the globus pallidus interna; insights from disease states","volume":"235","author":"Gillies MJ","year":"2017","unstructured":"Gillies MJ, Hyam JA, Weiss AR,  The cognitive role of the globus pallidus interna; insights from disease states. Exp Brain Res. 2017;235(5):1455\u20131465."},{"key":"b41","series-title":"Behav Brain Res","first-page":"113787","article-title":"Cognitive task-related oscillations in human internal globus pallidus and subthalamic nucleus","volume":"424","author":"Navid MS","year":"2022","unstructured":"Navid MS, Kammermeier S, Niazi IK,  Cognitive task-related oscillations in human internal globus pallidus and subthalamic nucleus. Behav Brain Res. 2022;424113787."},{"issue":"11","key":"b42","series-title":"J Neurosci","first-page":"2965","article-title":"Context-dependent modulation of movement-related discharge in the primate globus pallidus","volume":"25","author":"Turner RS","year":"2005","unstructured":"Turner RS, Anderson ME. Context-dependent modulation of movement-related discharge in the primate globus pallidus. J Neurosci. 2005;25(11):2965\u20132976."},{"issue":"5","key":"b43","series-title":"Ann Neurol","first-page":"586","article-title":"Cognition and mood in Parkinson\u2019s disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial","volume":"65","author":"Okun MS","year":"2009","unstructured":"Okun MS, Fernandez HH, Wu SS,  Cognition and mood in Parkinson\u2019s disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial. Ann Neurol. 2009;65(5):586\u2013595."},{"key":"b44","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988","unstructured":"Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Lawrence Erlbaum Associates;1988."},{"issue":"5","key":"b45","series-title":"Neurologist","first-page":"263","article-title":"DBS candidates that fall short on a levodopa challenge test: alternative and important indications","volume":"17","author":"Morishita T","year":"2011","unstructured":"Morishita T, Rahman M, Foote KD,  DBS candidates that fall short on a levodopa challenge test: alternative and important indications. 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