{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:04:49Z","timestamp":1780131889945,"version":"3.54.0"},"reference-count":154,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>Acute and chronic CNS pathologies that result in tissue loss remain among the most intractable problems in neurosurgery, with current treatments focused on stabilization and neuroprotection rather than structural repair. Neural interfaces such as recording, stimulating, or replacing neural activity have demonstrated value in restoring function via prostheses and brain-computer interfaces, yet these approaches are constrained by electrode design, bandwidth, and limited biological integration. Engineered neuroglial organoids offer a complementary, biologically based interface strategy.<\/jats:p>\n                  <jats:p>Derived from pluripotent stem cells, neuroglial organoids arrive as 3D constructs containing neurons and glia in intrinsic architecture, capable of vascularization, synaptic connectivity, and integration with host tissue. Building on dissociated stem cell suspensions, organoids act not only as reservoirs of cells but also as living neural interfaces, receiving inputs from host circuits and generating functional outputs. Preclinical studies have demonstrated that transplanted organoids can couple to host sensory pathways, respond to stimulation, and support recovery of motor and cognitive functions. Moreover, emerging work coupling organoid grafts to brain-computer interfaces highlights the potential for closed-loop biological electronic systems, in which engineered devices provide precise recording and stimulation while organoids contribute adaptive, active biological circuits. This combination allows real-time bidirectional communication, allowing the graft to be both monitored and adapted to structurally and functionally integrate into host tissue.<\/jats:p>\n                  <jats:p>In this review, the authors examine neuroglial organoid transplantation through the lens of neural interfacing. They outline lessons from non-CNS organoid transplantation, summarize neurotrauma studies where grafts engage host circuits, and highlight opportunities to integrate organoids with electrodes, stimulation paradigms, and computational models. They also discuss challenges, namely vascularization, immune tolerance, surgical delivery, and manufacturing standards, that parallel those in neural device translation. For neurosurgeons, the appeal of neuroglial organoids lies not only in tissue replacement but in establishing a new class of biological neural interfaces, extending the reach of restorative neurosurgery. By merging living constructs with engineered devices, organoid-based strategies may enable hybrid restorative systems that restore function after neurological injury and disease.<\/jats:p>","DOI":"10.3171\/2025.11.focus25911","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T15:14:50Z","timestamp":1769958890000},"page":"E5","source":"Crossref","is-referenced-by-count":1,"title":["Engineered neuroglial organoids as living neural interfaces for restorative neurosurgery"],"prefix":"10.3171","volume":"60","author":[{"given":"Vikas N.","family":"Vattipally","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katholiki","family":"Troumouchi","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens School of Medicine, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Shiino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tulane University School of Medicine, New Orleans, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Abouelseoud","sequence":"additional","affiliation":[{"name":"College of Behavioral and Social Sciences, University of Maryland, College Park;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaustubh","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Theodore","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Brem","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Bettegowda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren L.","family":"Jantzie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"},{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenandoah","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tej D.","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Kathuria","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"6","key":"b1","series-title":"Neurosurgery","first-page":"1246","article-title":"Concomitant traumatic brain injury delays surgery in patients with traumatic spinal cord injury","volume":"94","author":"Azad TD","year":"2024","unstructured":"Azad TD, Raj D, Ran KR,  Concomitant traumatic brain injury delays surgery in patients with traumatic spinal cord injury. Neurosurgery. 2024;94(6):1246\u20131252. doi:10.1227\/neu.0000000000002816"},{"issue":"3","key":"b2","series-title":"Int J Mol Sci","first-page":"1851","article-title":"A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics","volume":"23","author":"Lamptey RNL","year":"2022","unstructured":"Lamptey RNL, Chaulagain B, Trivedi R, Gothwal A, Layek B, Singh J. A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics. Int J Mol Sci. 2022;23(3):1851. doi:10.3390\/ijms23031851"},{"issue":"3","key":"b3","series-title":"J Neurosurg Spine","first-page":"375","article-title":"Association between concomitant traumatic brain injury and unfavorable 1-year outcomes in patients with traumatic spinal cord injury","volume":"43","author":"Vattipally VN","year":"2025","unstructured":"Vattipally VN, Aude CA, Ran KR,  Association between concomitant traumatic brain injury and unfavorable 1-year outcomes in patients with traumatic spinal cord injury. J Neurosurg Spine. 2025;43(3):375\u2013383. doi:10.3171\/2025.3.SPINE241470"},{"key":"b4","series-title":"StatPearls","article-title":"Spinal cord injuries","author":"Margetis K","year":"2025","unstructured":"Margetis K, Das JM, Emmady PD. Spinal cord injuries. In: StatPearls. StatPearls Publishing; 2025. Accessed December 12, 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK560721\/"},{"key":"b5","series-title":"StatPearls","article-title":"Traumatic brain injury","author":"Ginsburg J","year":"2025","unstructured":"Ginsburg J, Smith T. Traumatic brain injury. In: StatPearls. StatPearls Publishing; 2025.Accessed December 12, 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557861\/"},{"issue":"6","key":"b6","series-title":"Neurosurgery","first-page":"1357","article-title":"Association between operative neurosurgical intervention and favorable discharge among patients with traumatic subdural hematoma and poor neurological examination","volume":"97","author":"Azad TD","year":"2025","unstructured":"Azad TD, Vattipally VN, Ran KR,  Association between operative neurosurgical intervention and favorable discharge among patients with traumatic subdural hematoma and poor neurological examination. Neurosurgery. 2025;97(6):1357\u20131367. doi:10.1227\/neu.0000000000003477"},{"issue":"8","key":"b7","series-title":"Neurology","first-page":"e1202","article-title":"Cell therapy for chronic TBI: interim analysis of the randomized controlled STEMTRA trial","volume":"96","author":"Kawabori M","year":"2021","unstructured":"Kawabori M, Weintraub AH, Imai H,  Cell therapy for chronic TBI: interim analysis of the randomized controlled STEMTRA trial. Neurology. 2021;96(8):e1202\u2013e1214. doi:10.1212\/WNL.0000000000011450"},{"issue":"5","key":"b8","series-title":"Neurosurg Focus","first-page":"E2","article-title":"Neurorestoration after stroke","volume":"40","author":"Azad TD","year":"2016","unstructured":"Azad TD, Veeravagu A, Steinberg GK. Neurorestoration after stroke. Neurosurg Focus. 2016;40(5):E2. doi:10.3171\/2016.2.FOCUS15637"},{"key":"b9","series-title":"Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Frontiers in Neuroengineering","article-title":"Stem cell therapy in brain trauma: implications for repair and regeneration of injured brain in experimental TBI models","author":"Rolfe A","year":"2015","unstructured":"Rolfe A, Sun D. Stem cell therapy in brain trauma: implications for repair and regeneration of injured brain in experimental TBI models. In: Kobeissy FH, ed. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Frontiers in Neuroengineering. CRC Press\/Taylor & Francis;2015.Accessed December 12, 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK299210\/"},{"issue":"6","key":"b10","series-title":"Cells Tissues Organs","first-page":"655","article-title":"Biomaterial strategies to bolster neural stem cell-mediated repair of the central nervous system","volume":"211","author":"Tejeda G","year":"2022","unstructured":"Tejeda G, Ciciriello AJ, Dumont CM. Biomaterial strategies to bolster neural stem cell-mediated repair of the central nervous system. 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Int J Mol Sci. 2024;25(15):8540. doi:10.3390\/ijms25158540"},{"issue":"1-2","key":"b13","series-title":"Pediatr Res","first-page":"345","article-title":"Stem cells and cell-based therapies for cerebral palsy: a call for rigor","volume":"83","author":"Jantzie LL","year":"2018","unstructured":"Jantzie LL, Scafidi J, Robinson S. Stem cells and cell-based therapies for cerebral palsy: a call for rigor. Pediatr Res. 2018;83(1-2):345\u2013355. doi:10.1038\/pr.2017.233"},{"issue":"1","key":"b14","series-title":"Nat Commun","first-page":"1861","article-title":"Bio-inspired electronics: soft, biohybrid, and \"living\" neural interfaces","volume":"16","author":"Boufidis D","year":"2025","unstructured":"Boufidis D, Garg R, Angelopoulos E, Cullen DK, Vitale F. Bio-inspired electronics: soft, biohybrid, and \"living\" neural interfaces. Nat Commun. 2025;16(1):1861. doi:10.1038\/s41467-025-57016-0"},{"issue":"13","key":"b15","series-title":"J Neurotrauma","first-page":"1180","article-title":"Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage","volume":"31","author":"Glushakova OY","year":"2014","unstructured":"Glushakova OY, Johnson D, Hayes RL. Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. J Neurotrauma. 2014;31(13):1180\u20131193. doi:10.1089\/neu.2013.3080"},{"key":"b16","series-title":"Front Cell Neurosci","first-page":"1335849","article-title":"Reactive gliosis in traumatic brain injury: a comprehensive review","volume":"18","author":"Amlerova Z","year":"2024","unstructured":"Amlerova Z, Chmelova M, Anderova M, Vargova L. Reactive gliosis in traumatic brain injury: a comprehensive review. Front Cell Neurosci. 2024;18:1335849. doi:10.3389\/fncel.2024.1335849"},{"issue":"1","key":"b17","series-title":"Cell Tissue Res","first-page":"169","article-title":"Role of the lesion scar in the response to damage and repair of the central nervous system","volume":"349","author":"Kawano H","year":"2012","unstructured":"Kawano H, Kimura-Kuroda J, Komuta Y,  Role of the lesion scar in the response to damage and repair of the central nervous system. Cell Tissue Res. 2012;349(1):169\u2013180. doi:10.1007\/s00441-012-1336-5"},{"issue":"2","key":"b18","series-title":"Neural Regen Res","first-page":"506","article-title":"Neuromodulation technologies improve functional recovery after brain injury: from bench to bedside","volume":"21","author":"Liu M","year":"2026","unstructured":"Liu M, Meng Y, Ouyang S,  Neuromodulation technologies improve functional recovery after brain injury: from bench to bedside. Neural Regen Res. 2026;21(2):506\u2013520. doi:10.4103\/NRR.NRR-D-24-00652"},{"issue":"3","key":"b19","series-title":"Cytotherapy","first-page":"186","article-title":"Current evidence on mesenchymal stem cell therapy for traumatic spinal cord injury: systematic review and meta-analysis","volume":"23","author":"Muthu S","year":"2021","unstructured":"Muthu S, Jeyaraman M, Gulati A, Arora A. Current evidence on mesenchymal stem cell therapy for traumatic spinal cord injury: systematic review and meta-analysis. 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Stem Cell Res Ther. 2014;5(4):91. doi:10.1186\/scrt480"},{"issue":"3","key":"b26","series-title":"Int J Mol Sci","first-page":"2528","article-title":"Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury","volume":"24","author":"Suzuki H","year":"2023","unstructured":"Suzuki H, Imajo Y, Funaba M, Ikeda H, Nishida N, Sakai T. Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury. Int J Mol Sci. 2023;24(3):2528. doi:10.3390\/ijms24032528"},{"issue":"6","key":"b27","series-title":"Curr Opin Neurol","first-page":"804","article-title":"Combined neuromodulatory approaches in the central nervous system for treatment of spinal cord injury","volume":"34","author":"Noga BR","year":"2021","unstructured":"Noga BR, Guest JD. Combined neuromodulatory approaches in the central nervous system for treatment of spinal cord injury. Curr Opin Neurol. 2021;34(6):804\u2013811. doi:10.1097\/WCO.0000000000000999"},{"issue":"4","key":"b28","series-title":"Nat Biomed Eng","first-page":"435","article-title":"Production of human spinal-cord organoids recapitulating neural-tube morphogenesis","volume":"6","author":"Lee JH","year":"2022","unstructured":"Lee JH, Shin H, Shaker MR,  Production of human spinal-cord organoids recapitulating neural-tube morphogenesis. Nat Biomed Eng. 2022;6(4):435\u2013448. doi:10.1038\/s41551-022-00868-4"},{"issue":"1","key":"b29","series-title":"Sci Rep","first-page":"13536","article-title":"Characterization of neural mechanotransduction response in human traumatic brain injury organoid model","volume":"13","author":"Beltr\u00e1n SM","year":"2023","unstructured":"Beltr\u00e1n SM, Bobo J, Habib A,  Characterization of neural mechanotransduction response in human traumatic brain injury organoid model. Sci Rep. 2023;13(1):13536. doi:10.1038\/s41598-023-40431-y"},{"issue":"1","key":"b30","series-title":"iScience","first-page":"105898","article-title":"Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing","volume":"26","author":"Xue W","year":"2023","unstructured":"Xue W, Li B, Liu H,  Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing. iScience. 2023;26(1):105898. doi:10.1016\/j.isci.2022.105898"},{"issue":"7","key":"b31","series-title":"CNS Neurosci Ther","first-page":"682","article-title":"Cerebral organoids transplantation improves neurological motor function in rat brain injury","volume":"26","author":"Wang Z","year":"2020","unstructured":"Wang Z, Wang SN, Xu TY,  Cerebral organoids transplantation improves neurological motor function in rat brain injury. CNS Neurosci Ther. 2020;26(7):682\u2013697. doi:10.1111\/cns.13286"},{"issue":"1","key":"b32","series-title":"J Transl Med","first-page":"767","article-title":"Remodeling and repair of the damaged brain: the potential and challenges of organoids for ischaemic stroke","volume":"23","author":"Hao YX","year":"2025","unstructured":"Hao YX, Li CR, Lu ZJ,  Remodeling and repair of the damaged brain: the potential and challenges of organoids for ischaemic stroke. J Transl Med. 2025;23(1):767. doi:10.1186\/s12967-025-06736-4"},{"issue":"6","key":"b33","series-title":"Cell","first-page":"1264","article-title":"Long-distance growth and connectivity of neural stem cells after severe spinal cord injury","volume":"150","author":"Lu P","year":"2012","unstructured":"Lu P, Wang Y, Graham L,  Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012;150(6):1264\u20131273. doi:10.1016\/j.cell.2012.08.020"},{"issue":"1-2","key":"b34","series-title":"J Neuroimmunol","first-page":"78","article-title":"Inflammation and gliosis in neurological diseases\u2014clinical implications","volume":"231","author":"Cz\u0142onkowska A","year":"2011","unstructured":"Cz\u0142onkowska A, Kurkowska-Jastrz\u0119bska I. Inflammation and gliosis in neurological diseases\u2014clinical implications. J Neuroimmunol. 2011;231(1-2):78\u201385. doi:10.1016\/j.jneuroim.2010.09.020"},{"issue":"1","key":"b35","series-title":"Nat Commun","first-page":"84","article-title":"Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts","volume":"9","author":"Dulin JN","year":"2018","unstructured":"Dulin JN, Adler AF, Kumamaru H,  Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. Nat Commun. 2018;9(1):84. doi:10.1038\/s41467-017-02613-x"},{"issue":"5","key":"b36","series-title":"Nat Med","first-page":"479","article-title":"Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration","volume":"22","author":"Kadoya K","year":"2016","unstructured":"Kadoya K, Lu P, Nguyen K,  Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nat Med. 2016;22(5):479\u2013487. doi:10.1038\/nm.4066"},{"issue":"4","key":"b37","series-title":"Nat Med","first-page":"618","article-title":"Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell","volume":"18","author":"Yui S","year":"2012","unstructured":"Yui S, Nakamura T, Sato T,  Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nat Med. 2012;18(4):618\u2013623. doi:10.1038\/nm.2695"},{"issue":"11","key":"b38","series-title":"Nat Med","first-page":"1310","article-title":"An in vivo model of human small intestine using pluripotent stem cells","volume":"20","author":"Watson CL","year":"2014","unstructured":"Watson CL, Mahe MM, M\u00fanera J,  An in vivo model of human small intestine using pluripotent stem cells. Nat Med. 2014;20(11):1310\u20131314. doi:10.1038\/nm.3737"},{"issue":"757","key":"b39","series-title":"Sci Transl Med","first-page":"eadg0338","article-title":"Human iPSC\u2013liver organoid transplantation reduces fibrosis through immunomodulation","volume":"16","author":"Tadokoro T","year":"2024","unstructured":"Tadokoro T, Murata S, Kato M,  Human iPSC\u2013liver organoid transplantation reduces fibrosis through immunomodulation. Sci Transl Med. 2024;16(757):eadg0338. doi:10.1126\/scitranslmed.adg0338"},{"issue":"7459","key":"b40","series-title":"Nature","first-page":"481","article-title":"Vascularized and functional human liver from an iPSC-derived organ bud transplant","volume":"499","author":"Takebe T","year":"2013","unstructured":"Takebe T, Sekine K, Enomura M,  Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013;499(7459):481\u2013484. doi:10.1038\/nature12271"},{"issue":"6","key":"b41","series-title":"Cell","first-page":"1623","article-title":"Cell types of the human retina and its organoids at single-cell resolution","volume":"182","author":"Cowan CS","year":"2020","unstructured":"Cowan CS, Renner M, De Gennaro M,  Cell types of the human retina and its organoids at single-cell resolution. Cell. 2020;182(6):1623\u20131640.e34. doi:10.1016\/j.cell.2020.08.013"},{"issue":"8054","key":"b42","series-title":"Nature","first-page":"503","article-title":"Engineered heart muscle allografts for heart repair in primates and humans","volume":"639","author":"Jebran AF","year":"2025","unstructured":"Jebran AF, Seidler T, Tiburcy M,  Engineered heart muscle allografts for heart repair in primates and humans. 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Transplantation of neural progenitor cells in chronic spinal cord injury. Neuroscience. 2016;320:69\u201382. doi:10.1016\/j.neuroscience.2016.01.066"},{"key":"b45","series-title":"Brain Res","first-page":"87","article-title":"Transplantation of artificial neural construct partly improved spinal tissue repair and functional recovery in rats with spinal cord transection","volume":"1400","author":"Du BL","year":"2011","unstructured":"Du BL, Xiong Y, Zeng CG,  Transplantation of artificial neural construct partly improved spinal tissue repair and functional recovery in rats with spinal cord transection. Brain Res. 2011;1400:87\u201398. doi:10.1016\/j.brainres.2011.05.019"},{"issue":"7","key":"b46","series-title":"J Neurosci Res","first-page":"1394","article-title":"Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets","volume":"88","author":"Yamane J","year":"2010","unstructured":"Yamane J, Nakamura M, Iwanami A,  Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets. J Neurosci Res. 2010;88(7):1394\u20131405. doi:10.1002\/jnr.22322"},{"issue":"3","key":"b47","series-title":"Epilepsy Curr","first-page":"179","article-title":"From stumbling blocks to stepping stones: progress in treating temporal lobe epilepsy with stem cell transplantation","volume":"25","author":"Naegele JR","year":"2025","unstructured":"Naegele JR. From stumbling blocks to stepping stones: progress in treating temporal lobe epilepsy with stem cell transplantation. Epilepsy Curr. 2025;25(3):179\u2013183. doi:10.1177\/15357597251318571"},{"issue":"3","key":"b48","series-title":"Organoids","first-page":"16","article-title":"A concise review of organoid tissue engineering: regenerative applications and precision medicine","volume":"4","author":"Makesh KY","year":"2025","unstructured":"Makesh KY, Navaneethan A, Ajay M,  A concise review of organoid tissue engineering: regenerative applications and precision medicine. Organoids. 2025;4(3):16. doi:10.3390\/organoids4030016"},{"issue":"2","key":"b49","series-title":"Cell Stem Cell","first-page":"137","article-title":"Structural and functional integration of human forebrain organoids with the injured adult rat visual system","volume":"30","author":"Jgamadze D","year":"2023","unstructured":"Jgamadze D, Lim JT, Zhang Z,  Structural and functional integration of human forebrain organoids with the injured adult rat visual system. 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Adv Healthc Mater. 2025;14(24):e04817. doi:10.1002\/adhm.202404817"},{"key":"b58","series-title":"Front Cell Dev Biol","first-page":"1288168","article-title":"Challenges involved in cell therapy for Parkinson\u2019s disease using human pluripotent stem cells","volume":"11","author":"Moon H","year":"2023","unstructured":"Moon H, Kim B, Kwon I, Oh Y. Challenges involved in cell therapy for Parkinson\u2019s disease using human pluripotent stem cells. Front Cell Dev Biol. 2023;11:1288168. doi:10.3389\/fcell.2023.1288168"},{"issue":"6","key":"b59","series-title":"Cell Rep","first-page":"703","article-title":"Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions","volume":"1","author":"Kirkeby A","year":"2012","unstructured":"Kirkeby A, Grealish S, Wolf DA,  Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. 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Stem Cell Res Ther. 2020;11(1):94. doi:10.1186\/s13287-020-1585-2"},{"key":"b66","series-title":"bioRxiv","article-title":"Intravital multimodal imaging of human cortical organoids for chronic stroke treatment in mice","author":"Wang J","unstructured":"Wang J, Qiao G, Tan H,  Intravital multimodal imaging of human cortical organoids for chronic stroke treatment in mice. bioRxiv. Preprint posted online July 6, 2025. doi:10.1101\/2025.07.05.663297"},{"issue":"5","key":"b67","series-title":"J Clin Invest","first-page":"e185463","article-title":"A multi-analyte blood test for acute spinal cord injury","volume":"135","author":"Azad TD","year":"2025","unstructured":"Azad TD, Ran KR, Materi JD,  A multi-analyte blood test for acute spinal cord injury. J Clin Invest. 2025;135(5):e185463. doi:10.1172\/JCI185463"},{"issue":"8","key":"b68","series-title":"Biomarkers","first-page":"703","article-title":"A future blood test for acute traumatic spinal cord injury","volume":"28","author":"Azad TD","year":"2023","unstructured":"Azad TD, Ran KR, Liu J,  A future blood test for acute traumatic spinal cord injury. Biomarkers. 2023;28(8):703\u2013713. doi:10.1080\/1354750X.2023.2298650"},{"issue":"5","key":"b69","series-title":"PLoS Biol","first-page":"e3000705","article-title":"Vascularized human cortical organoids (vOrganoids) model cortical development in vivo","volume":"18","author":"Shi Y","year":"2020","unstructured":"Shi Y, Sun L, Wang M,  Vascularized human cortical organoids (vOrganoids) model cortical development in vivo. 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J Adv Res. 2025;73:375\u2013395. doi:10.1016\/j.jare.2024.08.035"},{"issue":"6","key":"b1","series-title":"Neurosurgery","first-page":"1246","article-title":"Concomitant traumatic brain injury delays surgery in patients with traumatic spinal cord injury","volume":"94","author":"Azad TD","year":"2024","unstructured":"Azad TD, Raj D, Ran KR,  Concomitant traumatic brain injury delays surgery in patients with traumatic spinal cord injury. Neurosurgery. 2024;94(6):1246\u20131252. doi:10.1227\/neu.0000000000002816"},{"issue":"3","key":"b2","series-title":"Int J Mol Sci","first-page":"1851","article-title":"A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics","volume":"23","author":"Lamptey RNL","year":"2022","unstructured":"Lamptey RNL, Chaulagain B, Trivedi R, Gothwal A, Layek B, Singh J. A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics. Int J Mol Sci. 2022;23(3):1851. doi:10.3390\/ijms23031851"},{"issue":"3","key":"b3","series-title":"J Neurosurg Spine","first-page":"375","article-title":"Association between concomitant traumatic brain injury and unfavorable 1-year outcomes in patients with traumatic spinal cord injury","volume":"43","author":"Vattipally VN","year":"2025","unstructured":"Vattipally VN, Aude CA, Ran KR,  Association between concomitant traumatic brain injury and unfavorable 1-year outcomes in patients with traumatic spinal cord injury. J Neurosurg Spine. 2025;43(3):375\u2013383. doi:10.3171\/2025.3.SPINE241470"},{"key":"b4","series-title":"StatPearls","article-title":"Spinal cord injuries","author":"Margetis K","year":"2025","unstructured":"Margetis K, Das JM, Emmady PD. Spinal cord injuries. In: StatPearls. StatPearls Publishing; 2025. Accessed December 12, 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK560721\/"},{"key":"b5","series-title":"StatPearls","article-title":"Traumatic brain injury","author":"Ginsburg J","year":"2025","unstructured":"Ginsburg J, Smith T. Traumatic brain injury. In: StatPearls. StatPearls Publishing; 2025.Accessed December 12, 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557861\/"},{"issue":"6","key":"b6","series-title":"Neurosurgery","first-page":"1357","article-title":"Association between operative neurosurgical intervention and favorable discharge among patients with traumatic subdural hematoma and poor neurological examination","volume":"97","author":"Azad TD","year":"2025","unstructured":"Azad TD, Vattipally VN, Ran KR,  Association between operative neurosurgical intervention and favorable discharge among patients with traumatic subdural hematoma and poor neurological examination. Neurosurgery. 2025;97(6):1357\u20131367. doi:10.1227\/neu.0000000000003477"},{"issue":"8","key":"b7","series-title":"Neurology","first-page":"e1202","article-title":"Cell therapy for chronic TBI: interim analysis of the randomized controlled STEMTRA trial","volume":"96","author":"Kawabori M","year":"2021","unstructured":"Kawabori M, Weintraub AH, Imai H,  Cell therapy for chronic TBI: interim analysis of the randomized controlled STEMTRA trial. Neurology. 2021;96(8):e1202\u2013e1214. doi:10.1212\/WNL.0000000000011450"},{"issue":"5","key":"b8","series-title":"Neurosurg Focus","first-page":"E2","article-title":"Neurorestoration after stroke","volume":"40","author":"Azad TD","year":"2016","unstructured":"Azad TD, Veeravagu A, Steinberg GK. Neurorestoration after stroke. Neurosurg Focus. 2016;40(5):E2. doi:10.3171\/2016.2.FOCUS15637"},{"key":"b9","series-title":"Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Frontiers in Neuroengineering","article-title":"Stem cell therapy in brain trauma: implications for repair and regeneration of injured brain in experimental TBI models","author":"Rolfe A","year":"2015","unstructured":"Rolfe A, Sun D. Stem cell therapy in brain trauma: implications for repair and regeneration of injured brain in experimental TBI models. In: Kobeissy FH, ed. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Frontiers in Neuroengineering. CRC Press\/Taylor & Francis;2015.Accessed December 12, 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK299210\/"},{"issue":"6","key":"b10","series-title":"Cells Tissues Organs","first-page":"655","article-title":"Biomaterial strategies to bolster neural stem cell-mediated repair of the central nervous system","volume":"211","author":"Tejeda G","year":"2022","unstructured":"Tejeda G, Ciciriello AJ, Dumont CM. Biomaterial strategies to bolster neural stem cell-mediated repair of the central nervous system. Cells Tissues Organs. 2022;211(6):655\u2013669. doi:10.1159\/000515351"},{"issue":"2","key":"b11","series-title":"Mol Cells","first-page":"53","article-title":"Neural organoids, a versatile model for neuroscience","volume":"45","author":"Lee JH","year":"2022","unstructured":"Lee JH, Sun W. Neural organoids, a versatile model for neuroscience. Mol Cells. 2022;45(2):53\u201364. doi:10.14348\/molcells.2022.2019"},{"issue":"15","key":"b12","series-title":"Int J Mol Sci","first-page":"8540","article-title":"Therapeutic transplantation of human central nervous system organoids for neural reconstruction","volume":"25","author":"Hong SJ","year":"2024","unstructured":"Hong SJ, Bock M, Zhang S, An SB, Han I. Therapeutic transplantation of human central nervous system organoids for neural reconstruction. Int J Mol Sci. 2024;25(15):8540. doi:10.3390\/ijms25158540"},{"issue":"1-2","key":"b13","series-title":"Pediatr Res","first-page":"345","article-title":"Stem cells and cell-based therapies for cerebral palsy: a call for rigor","volume":"83","author":"Jantzie LL","year":"2018","unstructured":"Jantzie LL, Scafidi J, Robinson S. Stem cells and cell-based therapies for cerebral palsy: a call for rigor. Pediatr Res. 2018;83(1-2):345\u2013355. doi:10.1038\/pr.2017.233"},{"issue":"1","key":"b14","series-title":"Nat Commun","first-page":"1861","article-title":"Bio-inspired electronics: soft, biohybrid, and \"living\" neural interfaces","volume":"16","author":"Boufidis D","year":"2025","unstructured":"Boufidis D, Garg R, Angelopoulos E, Cullen DK, Vitale F. Bio-inspired electronics: soft, biohybrid, and \"living\" neural interfaces. Nat Commun. 2025;16(1):1861. doi:10.1038\/s41467-025-57016-0"},{"issue":"13","key":"b15","series-title":"J Neurotrauma","first-page":"1180","article-title":"Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage","volume":"31","author":"Glushakova OY","year":"2014","unstructured":"Glushakova OY, Johnson D, Hayes RL. Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. J Neurotrauma. 2014;31(13):1180\u20131193. doi:10.1089\/neu.2013.3080"},{"key":"b16","series-title":"Front Cell Neurosci","first-page":"1335849","article-title":"Reactive gliosis in traumatic brain injury: a comprehensive review","volume":"18","author":"Amlerova Z","year":"2024","unstructured":"Amlerova Z, Chmelova M, Anderova M, Vargova L. Reactive gliosis in traumatic brain injury: a comprehensive review. Front Cell Neurosci. 2024;18:1335849. doi:10.3389\/fncel.2024.1335849"},{"issue":"1","key":"b17","series-title":"Cell Tissue Res","first-page":"169","article-title":"Role of the lesion scar in the response to damage and repair of the central nervous system","volume":"349","author":"Kawano H","year":"2012","unstructured":"Kawano H, Kimura-Kuroda J, Komuta Y,  Role of the lesion scar in the response to damage and repair of the central nervous system. Cell Tissue Res. 2012;349(1):169\u2013180. doi:10.1007\/s00441-012-1336-5"},{"issue":"2","key":"b18","series-title":"Neural Regen Res","first-page":"506","article-title":"Neuromodulation technologies improve functional recovery after brain injury: from bench to bedside","volume":"21","author":"Liu M","year":"2026","unstructured":"Liu M, Meng Y, Ouyang S,  Neuromodulation technologies improve functional recovery after brain injury: from bench to bedside. Neural Regen Res. 2026;21(2):506\u2013520. doi:10.4103\/NRR.NRR-D-24-00652"},{"issue":"3","key":"b19","series-title":"Cytotherapy","first-page":"186","article-title":"Current evidence on mesenchymal stem cell therapy for traumatic spinal cord injury: systematic review and meta-analysis","volume":"23","author":"Muthu S","year":"2021","unstructured":"Muthu S, Jeyaraman M, Gulati A, Arora A. Current evidence on mesenchymal stem cell therapy for traumatic spinal cord injury: systematic review and meta-analysis. Cytotherapy. 2021;23(3):186\u2013197. doi:10.1016\/j.jcyt.2020.09.007"},{"issue":"7","key":"b20","series-title":"Neurology","first-page":"e209797","article-title":"Mesenchymal stromal cell implants for chronic motor deficits after traumatic brain injury: post hoc analysis of a randomized trial","volume":"103","author":"Okonkwo DO","year":"2024","unstructured":"Okonkwo DO, McAllister P, Achrol AS,  Mesenchymal stromal cell implants for chronic motor deficits after traumatic brain injury: post hoc analysis of a randomized trial. Neurology. 2024;103(7):e209797. doi:10.1212\/WNL.0000000000209797"},{"issue":"7","key":"b21","series-title":"Nat Med","first-page":"2076","article-title":"Stem cell therapies advance in Parkinson\u2019s disease and beyond","volume":"31","author":"Healey N","year":"2025","unstructured":"Healey N. Stem cell therapies advance in Parkinson\u2019s disease and beyond. Nat Med. 2025;31(7):2076\u20132078. doi:10.1038\/d41591-025-00036-6"},{"issue":"2","key":"b22","series-title":"Cell Stem Cell","first-page":"343","article-title":"Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use","volume":"28","author":"Kim TW","year":"2021","unstructured":"Kim TW, Piao J, Koo SY,  Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use. Cell Stem Cell. 2021;28(2):343\u2013355.e5. doi:10.1016\/j.stem.2021.01.005"},{"key":"b23","series-title":"Front Immunol","first-page":"751021","article-title":"Neuroinflammation and scarring after spinal cord injury: therapeutic roles of MSCs on inflammation and glial scar","volume":"12","author":"Pang QM","year":"2021","unstructured":"Pang QM, Chen SY, Xu QJ,  Neuroinflammation and scarring after spinal cord injury: therapeutic roles of MSCs on inflammation and glial scar. Front Immunol. 2021;12:751021. doi:10.3389\/fimmu.2021.751021"},{"issue":"5","key":"b24","series-title":"Stem Cell Reports","first-page":"102480","article-title":"Exercise promotes the functional integration of human stem cell-derived neural grafts in a rodent model of Parkinson\u2019s disease","volume":"20","author":"Moriarty N","year":"2025","unstructured":"Moriarty N, Fraser TD, Hunt CPJ,  Exercise promotes the functional integration of human stem cell-derived neural grafts in a rodent model of Parkinson\u2019s disease. Stem Cell Reports. 2025;20(5):102480. doi:10.1016\/j.stemcr.2025.102480"},{"issue":"4","key":"b25","series-title":"Stem Cell Res Ther","first-page":"91","article-title":"Repair of injured spinal cord using biomaterial scaffolds and stem cells","volume":"5","author":"Shrestha B","year":"2014","unstructured":"Shrestha B, Coykendall K, Li Y, Moon A, Priyadarshani P, Yao L. Repair of injured spinal cord using biomaterial scaffolds and stem cells. Stem Cell Res Ther. 2014;5(4):91. doi:10.1186\/scrt480"},{"issue":"3","key":"b26","series-title":"Int J Mol Sci","first-page":"2528","article-title":"Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury","volume":"24","author":"Suzuki H","year":"2023","unstructured":"Suzuki H, Imajo Y, Funaba M, Ikeda H, Nishida N, Sakai T. Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury. Int J Mol Sci. 2023;24(3):2528. doi:10.3390\/ijms24032528"},{"issue":"6","key":"b27","series-title":"Curr Opin Neurol","first-page":"804","article-title":"Combined neuromodulatory approaches in the central nervous system for treatment of spinal cord injury","volume":"34","author":"Noga BR","year":"2021","unstructured":"Noga BR, Guest JD. Combined neuromodulatory approaches in the central nervous system for treatment of spinal cord injury. Curr Opin Neurol. 2021;34(6):804\u2013811. doi:10.1097\/WCO.0000000000000999"},{"issue":"4","key":"b28","series-title":"Nat Biomed Eng","first-page":"435","article-title":"Production of human spinal-cord organoids recapitulating neural-tube morphogenesis","volume":"6","author":"Lee JH","year":"2022","unstructured":"Lee JH, Shin H, Shaker MR,  Production of human spinal-cord organoids recapitulating neural-tube morphogenesis. Nat Biomed Eng. 2022;6(4):435\u2013448. doi:10.1038\/s41551-022-00868-4"},{"issue":"1","key":"b29","series-title":"Sci Rep","first-page":"13536","article-title":"Characterization of neural mechanotransduction response in human traumatic brain injury organoid model","volume":"13","author":"Beltr\u00e1n SM","year":"2023","unstructured":"Beltr\u00e1n SM, Bobo J, Habib A,  Characterization of neural mechanotransduction response in human traumatic brain injury organoid model. Sci Rep. 2023;13(1):13536. doi:10.1038\/s41598-023-40431-y"},{"issue":"1","key":"b30","series-title":"iScience","first-page":"105898","article-title":"Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing","volume":"26","author":"Xue W","year":"2023","unstructured":"Xue W, Li B, Liu H,  Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing. iScience. 2023;26(1):105898. doi:10.1016\/j.isci.2022.105898"},{"issue":"7","key":"b31","series-title":"CNS Neurosci Ther","first-page":"682","article-title":"Cerebral organoids transplantation improves neurological motor function in rat brain injury","volume":"26","author":"Wang Z","year":"2020","unstructured":"Wang Z, Wang SN, Xu TY,  Cerebral organoids transplantation improves neurological motor function in rat brain injury. CNS Neurosci Ther. 2020;26(7):682\u2013697. doi:10.1111\/cns.13286"},{"issue":"1","key":"b32","series-title":"J Transl Med","first-page":"767","article-title":"Remodeling and repair of the damaged brain: the potential and challenges of organoids for ischaemic stroke","volume":"23","author":"Hao YX","year":"2025","unstructured":"Hao YX, Li CR, Lu ZJ,  Remodeling and repair of the damaged brain: the potential and challenges of organoids for ischaemic stroke. J Transl Med. 2025;23(1):767. doi:10.1186\/s12967-025-06736-4"},{"issue":"6","key":"b33","series-title":"Cell","first-page":"1264","article-title":"Long-distance growth and connectivity of neural stem cells after severe spinal cord injury","volume":"150","author":"Lu P","year":"2012","unstructured":"Lu P, Wang Y, Graham L,  Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012;150(6):1264\u20131273. doi:10.1016\/j.cell.2012.08.020"},{"issue":"1-2","key":"b34","series-title":"J Neuroimmunol","first-page":"78","article-title":"Inflammation and gliosis in neurological diseases\u2014clinical implications","volume":"231","author":"Cz\u0142onkowska A","year":"2011","unstructured":"Cz\u0142onkowska A, Kurkowska-Jastrz\u0119bska I. Inflammation and gliosis in neurological diseases\u2014clinical implications. J Neuroimmunol. 2011;231(1-2):78\u201385. doi:10.1016\/j.jneuroim.2010.09.020"},{"issue":"1","key":"b35","series-title":"Nat Commun","first-page":"84","article-title":"Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts","volume":"9","author":"Dulin JN","year":"2018","unstructured":"Dulin JN, Adler AF, Kumamaru H,  Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. 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Nature. 2025;639(8054):503\u2013511. doi:10.1038\/s41586-024-08463-0"},{"issue":"1","key":"b43","series-title":"Biomedicines","first-page":"35","article-title":"Stem cell therapy for the treatment of amyotrophic lateral sclerosis: comparison of the efficacy of mesenchymal stem cells, neural stem cells, and induced pluripotent stem cells","volume":"13","author":"Frawley L","year":"2024","unstructured":"Frawley L, Taylor NT, Sivills O,  Stem cell therapy for the treatment of amyotrophic lateral sclerosis: comparison of the efficacy of mesenchymal stem cells, neural stem cells, and induced pluripotent stem cells. Biomedicines. 2024;13(1):35. doi:10.3390\/biomedicines13010035"},{"key":"b44","series-title":"Neuroscience","first-page":"69","article-title":"Transplantation of neural progenitor cells in chronic spinal cord injury","volume":"320","author":"Jin Y","year":"2016","unstructured":"Jin Y, Bouyer J, Shumsky JS, Haas C, Fischer I. Transplantation of neural progenitor cells in chronic spinal cord injury. Neuroscience. 2016;320:69\u201382. doi:10.1016\/j.neuroscience.2016.01.066"},{"key":"b45","series-title":"Brain Res","first-page":"87","article-title":"Transplantation of artificial neural construct partly improved spinal tissue repair and functional recovery in rats with spinal cord transection","volume":"1400","author":"Du BL","year":"2011","unstructured":"Du BL, Xiong Y, Zeng CG,  Transplantation of artificial neural construct partly improved spinal tissue repair and functional recovery in rats with spinal cord transection. Brain Res. 2011;1400:87\u201398. doi:10.1016\/j.brainres.2011.05.019"},{"issue":"7","key":"b46","series-title":"J Neurosci Res","first-page":"1394","article-title":"Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets","volume":"88","author":"Yamane J","year":"2010","unstructured":"Yamane J, Nakamura M, Iwanami A,  Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets. J Neurosci Res. 2010;88(7):1394\u20131405. doi:10.1002\/jnr.22322"},{"issue":"3","key":"b47","series-title":"Epilepsy Curr","first-page":"179","article-title":"From stumbling blocks to stepping stones: progress in treating temporal lobe epilepsy with stem cell transplantation","volume":"25","author":"Naegele JR","year":"2025","unstructured":"Naegele JR. From stumbling blocks to stepping stones: progress in treating temporal lobe epilepsy with stem cell transplantation. Epilepsy Curr. 2025;25(3):179\u2013183. doi:10.1177\/15357597251318571"},{"issue":"3","key":"b48","series-title":"Organoids","first-page":"16","article-title":"A concise review of organoid tissue engineering: regenerative applications and precision medicine","volume":"4","author":"Makesh KY","year":"2025","unstructured":"Makesh KY, Navaneethan A, Ajay M,  A concise review of organoid tissue engineering: regenerative applications and precision medicine. Organoids. 2025;4(3):16. doi:10.3390\/organoids4030016"},{"issue":"2","key":"b49","series-title":"Cell Stem Cell","first-page":"137","article-title":"Structural and functional integration of human forebrain organoids with the injured adult rat visual system","volume":"30","author":"Jgamadze D","year":"2023","unstructured":"Jgamadze D, Lim JT, Zhang Z,  Structural and functional integration of human forebrain organoids with the injured adult rat visual system. 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Stem Cell Reports. 2020;15(2):467\u2013481. doi:10.1016\/j.stemcr.2020.06.016"},{"issue":"3","key":"b56","series-title":"Nat Biomed Eng","first-page":"253","article-title":"Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes","volume":"7","author":"Xu J","year":"2023","unstructured":"Xu J, Fang S, Deng S,  Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes. Nat Biomed Eng. 2023;7(3):253\u2013269. doi:10.1038\/s41551-022-00963-6"},{"issue":"24","key":"b57","series-title":"Adv Healthc Mater","first-page":"e04817","article-title":"3D-printed scaffolds promote enhanced spinal organoid formation for use in spinal cord injury","volume":"14","author":"Han G","year":"2025","unstructured":"Han G, Lavoie NS, Patil N,  3D-printed scaffolds promote enhanced spinal organoid formation for use in spinal cord injury. Adv Healthc Mater. 2025;14(24):e04817. doi:10.1002\/adhm.202404817"},{"key":"b58","series-title":"Front Cell Dev Biol","first-page":"1288168","article-title":"Challenges involved in cell therapy for Parkinson\u2019s disease using human pluripotent stem cells","volume":"11","author":"Moon H","year":"2023","unstructured":"Moon H, Kim B, Kwon I, Oh Y. Challenges involved in cell therapy for Parkinson\u2019s disease using human pluripotent stem cells. Front Cell Dev Biol. 2023;11:1288168. doi:10.3389\/fcell.2023.1288168"},{"issue":"6","key":"b59","series-title":"Cell Rep","first-page":"703","article-title":"Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions","volume":"1","author":"Kirkeby A","year":"2012","unstructured":"Kirkeby A, Grealish S, Wolf DA,  Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Rep. 2012;1(6):703\u2013714. doi:10.1016\/j.celrep.2012.04.009"},{"key":"b60","series-title":"Front Neurosci","first-page":"1283742","article-title":"Myelin organoids for the study of Alzheimer\u2019s disease","volume":"17","author":"Cerneckis J","year":"2023","unstructured":"Cerneckis J, Shi Y. Myelin organoids for the study of Alzheimer\u2019s disease. Front Neurosci. 2023;17:1283742. doi:10.3389\/fnins.2023.1283742"},{"issue":"7","key":"b61","series-title":"Mol Neurobiol","first-page":"4732","article-title":"Neural differentiation and spinal cord organoid generation from induced pluripotent stem cells (iPSCs) for ALS modelling and inflammatory screening","volume":"61","author":"Guo R","year":"2024","unstructured":"Guo R, Chen Y, Zhang J,  Neural differentiation and spinal cord organoid generation from induced pluripotent stem cells (iPSCs) for ALS modelling and inflammatory screening. Mol Neurobiol. 2024;61(7):4732\u20134749. doi:10.1007\/s12035-023-03836-4"},{"issue":"1","key":"b62","series-title":"NPJ Regen Med","first-page":"27","article-title":"Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke","volume":"8","author":"Cao SY","year":"2023","unstructured":"Cao SY, Yang D, Huang ZQ,  Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke. NPJ Regen Med. 2023;8(1):27. doi:10.1038\/s41536-023-00301-7"},{"issue":"5","key":"b63","series-title":"Cell Stem Cell","first-page":"772","article-title":"Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids","volume":"31","author":"Sun Z","year":"2024","unstructured":"Sun Z, Chen Z, Yin M,  Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids. Cell Stem Cell. 2024;31(5):772\u2013787.e11. doi:10.1016\/j.stem.2024.03.007"},{"issue":"2","key":"b64","series-title":"Cell Stem Cell","first-page":"219","article-title":"Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons","volume":"30","author":"\u00c1lvarez Z","year":"2023","unstructured":"\u00c1lvarez Z, Ortega JA, Sato K,  Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons. Cell Stem Cell. 2023;30(2):219\u2013238.e14. doi:10.1016\/j.stem.2022.12.010"},{"issue":"1","key":"b65","series-title":"Stem Cell Res Ther","first-page":"94","article-title":"Standardized GMP-compliant scalable production of human pancreas organoids","volume":"11","author":"Dossena M","year":"2020","unstructured":"Dossena M, Piras R, Cherubini A,  Standardized GMP-compliant scalable production of human pancreas organoids. Stem Cell Res Ther. 2020;11(1):94. doi:10.1186\/s13287-020-1585-2"},{"key":"b66","series-title":"bioRxiv","article-title":"Intravital multimodal imaging of human cortical organoids for chronic stroke treatment in mice","author":"Wang J","unstructured":"Wang J, Qiao G, Tan H,  Intravital multimodal imaging of human cortical organoids for chronic stroke treatment in mice. bioRxiv. Preprint posted online July 6, 2025. doi:10.1101\/2025.07.05.663297"},{"issue":"5","key":"b67","series-title":"J Clin Invest","first-page":"e185463","article-title":"A multi-analyte blood test for acute spinal cord injury","volume":"135","author":"Azad TD","year":"2025","unstructured":"Azad TD, Ran KR, Materi JD,  A multi-analyte blood test for acute spinal cord injury. J Clin Invest. 2025;135(5):e185463. doi:10.1172\/JCI185463"},{"issue":"8","key":"b68","series-title":"Biomarkers","first-page":"703","article-title":"A future blood test for acute traumatic spinal cord injury","volume":"28","author":"Azad TD","year":"2023","unstructured":"Azad TD, Ran KR, Liu J,  A future blood test for acute traumatic spinal cord injury. Biomarkers. 2023;28(8):703\u2013713. doi:10.1080\/1354750X.2023.2298650"},{"issue":"5","key":"b69","series-title":"PLoS Biol","first-page":"e3000705","article-title":"Vascularized human cortical organoids (vOrganoids) model cortical development in vivo","volume":"18","author":"Shi Y","year":"2020","unstructured":"Shi Y, Sun L, Wang M,  Vascularized human cortical organoids (vOrganoids) model cortical development in vivo. PLoS Biol. 2020;18(5):e3000705. doi:10.1371\/journal.pbio.3000705"},{"issue":"4","key":"b70","series-title":"Curr Stem Cell Rep","first-page":"206","article-title":"Immune editing: overcoming immune barriers in stem cell transplantation","volume":"8","author":"Meissner TB","year":"2022","unstructured":"Meissner TB, Schulze HS, Dale SM. Immune editing: overcoming immune barriers in stem cell transplantation. Curr Stem Cell Rep. 2022;8(4):206\u2013218. doi:10.1007\/s40778-022-00221-0"},{"issue":"3","key":"b71","series-title":"Neural Regen Res","first-page":"837","article-title":"Human cerebral organoids: complex, versatile, and human-relevant models of neural development and brain diseases","volume":"21","author":"Coronel R","year":"2026","unstructured":"Coronel R, Gonz\u00e1lez-Sastre R, Mateos-Mart\u00ednez P,  Human cerebral organoids: complex, versatile, and human-relevant models of neural development and brain diseases. Neural Regen Res. 2026;21(3):837\u2013854. doi:10.4103\/NRR.NRR-D-24-01639"},{"issue":"1","key":"b72","series-title":"J Funct Biomater","first-page":"20","article-title":"Development of a nanoparticle system for controlled release in bioprinted respiratory scaffolds","volume":"15","author":"Zimmerling A","year":"2024","unstructured":"Zimmerling A, Sunil C, Zhou Y, Chen X. Development of a nanoparticle system for controlled release in bioprinted respiratory scaffolds. J Funct Biomater. 2024;15(1):20. doi:10.3390\/jfb15010020"},{"issue":"1","key":"b73","series-title":"Nat Commun","first-page":"9580","article-title":"Constructing organoid-brain-computer interfaces for neurofunctional repair after brain injury","volume":"15","author":"Hu N","year":"2024","unstructured":"Hu N, Shi JX, Chen C,  Constructing organoid-brain-computer interfaces for neurofunctional repair after brain injury. 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