{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:46:32Z","timestamp":1782528392238,"version":"3.54.5"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,24]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>\n                      Pediatric neurointerventional procedures are uncommon and management protocols are often extrapolated from adult data. In adults, dual antiplatelet therapy (DAPT) with aspirin and a P2Y\n                      <jats:sub>12<\/jats:sub>\n                      receptor inhibitor is the standard of care to reduce thromboembolic events following placement of a stent or flow diverter. There is limited evidence regarding the safety and efficacy of DAPT in the pediatric population and its use remains off-label. The aim of this study was to evaluate the safety and efficacy of DAPT in children undergoing neurointerventional procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This single-center retrospective case series included pediatric patients (age \u2264 18 years) who underwent a neurointerventional procedure and received DAPT during a continuous period between 2016 and 2024. Data on patient demographics, procedural details, antiplatelet regimens, and clinical outcomes were collected. The primary outcomes were the incidence of thrombotic events (e.g., stroke and in-stent thrombosis) and major bleeding complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Fifteen patients (10 male, median age 12 years) were included in this analysis. Indications included arterial aneurysms (n = 8) and venous sinus stenosis (n = 6). All patients received DAPT and aspirin, while 13 received clopidogrel and 4 received ticagrelor (2 patients received both). No thromboembolic complications, strokes, or device thromboses occurred (0\/15, 95% CI 0.0%\u201321.8%). One patient (1\/15, 95% CI 0.2%\u201331.9%) experienced a significant retroperitoneal hemorrhage, which was likely related to vascular access and was medically managed. No other major adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In this case series, DAPT was well tolerated and appeared effective in preventing thromboembolic complications in pediatric patients after neurointerventional surgery. These findings support the use of DAPT in this population, although further prospective studies are needed to establish evidence-based guidelines for optimal dosing, timing, and duration of therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.12.peds25558","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:37:12Z","timestamp":1777084632000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Dual antiplatelet therapy in pediatric neurointerventional procedures: a retrospective case series"],"prefix":"10.3171","author":[{"given":"John","family":"Tumberger","sequence":"first","affiliation":[{"name":"School of Medicine, University of Kansas School of Medicine, Kansas City;"},{"name":"Division of Pediatric Critical Care, The University of Kansas Health System, Kansas City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Toews","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, The University of Kansas Health System, Kansas City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis R.","family":"Langner","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas School of Medicine, Kansas City;"},{"name":"Division of Pediatric Critical Care, The University of Kansas Health System, Kansas City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"P\u00e9rez Marqu\u00e8s","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas School of Medicine, Kansas City;"},{"name":"Division of Pediatric Critical Care, The University of Kansas Health System, Kansas City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Abraham","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas School of Medicine, Kansas City;"},{"name":"Division of Neurointerventional Surgery, The University of Kansas Health System, Kansas City, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ebersole","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas School of Medicine, Kansas City;"},{"name":"Division of Neurointerventional Surgery, The University of Kansas Health System, Kansas City, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn B.","family":"Sood","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas School of Medicine, Kansas City;"},{"name":"Division of Pediatric Critical Care, The University of Kansas Health System, Kansas City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"6","key":"b1","series-title":"J Neurosurg Pediatr","first-page":"685","article-title":"Epidemiology and outcomes of pediatric intracranial aneurysms: comparison with an adult population in a 30-year, prospective database","volume":"28","author":"Xu R","year":"2021","unstructured":"Xu R, Xie ME, Yang W,  Epidemiology and outcomes of pediatric intracranial aneurysms: comparison with an adult population in a 30-year, prospective database. 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