{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:22:52Z","timestamp":1794327772761,"version":"4.9.0"},"reference-count":41,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Spinal cord injury (SCI) disrupts supraspinal projections to spinal motor circuits, resulting in sensorimotor deficits. While emerging evidence implicates hypothalamic engagement in post-SCI locomotor recovery, the integrity of hypothalamic-cortical functional connectivity (FC) and its prognostic utility remain uncharacterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Here, the authors employed voxelwise resting-state functional MRI (fMRI) and multivariate pattern analysis to map hypothalamic-cortical FC alterations in 30 incomplete SCI patients relative to 30 demographically matched healthy controls (HCs). Longitudinal assessments at 6-month follow-up integrated clinical metrics (American Spinal Injury Association [ASIA] motor\/sensory scores) and transcriptomic decoding via spatial correlation with Allen Human Brain Atlas gene expression profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Mass univariate comparisons revealed reduced FC between the hypothalamus and key motor regions, supplementary motor area (SMA), precentral gyrus, and cerebellar crus in SCI patients versus HCs (cluster-level family-wise error\u2013corrected p &lt; 0.05). Baseline hypothalamic-SMA FC strength positively predicted initial motor impairment (Pearson\u2019s r = 0.76, p &lt; 0.001). Longitudinal analysis demonstrated FC reorganization paralleling motor recovery (\u0394FC vs \u0394ASIA motor score, r = 0.36, p = 0.04), and searchlight classification identified the precuneus with high classification accuracy for stratifying recovery trajectories. Transcriptomic mapping implicated dysregulated synaptic signaling genes in regions exhibiting FC abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The authors\u2019 investigation delineated a critical role for hypothalamic-cortical circuits in post-SCI motor recovery. The dynamic reconfiguration of hypothalamic-SMA connectivity, coupled with its prognostic value, positions this pathway as a biomarker for monitoring neuroplasticity in SCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.12.spine251026","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:15:38Z","timestamp":1779120938000},"page":"300-312","source":"Crossref","is-referenced-by-count":0,"title":["Aberrant hypothalamic-cortical functional connectivity in spinal cord injury: a neuroimaging-transcriptomic study for motor recovery prognostication"],"prefix":"10.3171","volume":"45","author":[{"given":"Jia","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital of Guizhou Medical University, The First Affiliated Hospital of Sun Yat-sen University, Guizhou Hospital, Guiyang;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Second People\u2019s Hospital of Hefei, Anhui Medical University Affiliated Hefei Hospital, Hefei, Anhui;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Neurol Clin","first-page":"471","article-title":"Acute traumatic spinal cord injury","volume":"39","author":"Eli I","year":"2021","unstructured":"Eli I, Lerner DP, Ghogawala Z. 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J Neurotrauma. 2021;38(9):1267\u20131284. doi:10.1089\/neu.2020.7473"},{"issue":"12","key":"b4","series-title":"Article in Spanish. Rev Neurol","first-page":"461","article-title":"Non-invasive brain and spinal cord stimulation for motor and functional recovery after a spinal cord injury","volume":"70","author":"Kumru H","year":"2020","unstructured":"Kumru H, Flores A, Rodr\u00edguez-Ca\u00f1\u00f3n M, Soriano I, Garc\u00eda L, Vidal-Sams\u00f3 J. Non-invasive brain and spinal cord stimulation for motor and functional recovery after a spinal cord injury. Article in Spanish. Rev Neurol. 2020;70(12):461\u2013477. doi:10.33588\/rn.7012.2019453"},{"issue":"3","key":"b5","series-title":"Sci Prog","first-page":"368504211031117","article-title":"Importance of brain alterations in spinal cord injury","volume":"104","author":"Zhao C","year":"2021","unstructured":"Zhao C, Bao SS, Xu M, Rao JS. Importance of brain alterations in spinal cord injury. Sci Prog. 2021;104(3):368504211031117. doi:10.1177\/00368504211031117"},{"issue":"12","key":"b6","series-title":"Nat Med","first-page":"3676","article-title":"Hypothalamic deep brain stimulation augments walking after spinal cord injury","volume":"30","author":"Cho N","year":"2024","unstructured":"Cho N, Squair JW, Aureli V,  Hypothalamic deep brain stimulation augments walking after spinal cord injury. Nat Med. 2024;30(12):3676\u20133686. doi:10.1038\/s41591-024-03306-x"},{"issue":"23","key":"b7","series-title":"Sci Adv","first-page":"eabn5345","article-title":"Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism","volume":"8","author":"Huang Z","year":"2022","unstructured":"Huang Z, Liu L, Zhang J,  Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Sci Adv. 2022;8(23):eabn5345. doi:10.1126\/sciadv.abn5345"},{"issue":"43","key":"b8","series-title":"Adv Sci (Weinh)","first-page":"e2403245","article-title":"Central role of hypothalamic circuits for acupuncture\u2019s anti-Parkinsonian effects","volume":"11","author":"Oh JY","year":"2024","unstructured":"Oh JY, Lee H, Jang SY,  Central role of hypothalamic circuits for acupuncture\u2019s anti-Parkinsonian effects. Adv Sci (Weinh). 2024;11(43):e2403245. doi:10.1002\/advs.202403245"},{"issue":"4","key":"b9","series-title":"Neuroradiol J","first-page":"305","article-title":"Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks","volume":"30","author":"Smitha KA","year":"2017","unstructured":"Smitha KA, Akhil Raja K, Arun KM,  Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks. Neuroradiol J. 2017;30(4):305\u2013317. doi:10.1177\/1971400917697342"},{"issue":"2","key":"b10","series-title":"Neurorehabil Neural Repair","first-page":"122","article-title":"Resting-state functional connectivity of the thalamus in complete spinal cord injury","volume":"34","author":"Karunakaran KD","year":"2020","unstructured":"Karunakaran KD, Yuan R, He J,  Resting-state functional connectivity of the thalamus in complete spinal cord injury. Neurorehabil Neural Repair. 2020;34(2):122\u2013133. doi:10.1177\/1545968319893299"},{"key":"b11","series-title":"Neuroimage Clin","first-page":"103414","article-title":"Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury","volume":"38","author":"Kowalski JL","year":"2023","unstructured":"Kowalski JL, Morse LR, Troy K,  Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury. Neuroimage Clin. 2023;38:103414. doi:10.1016\/j.nicl.2023.103414"},{"issue":"1","key":"b12","series-title":"Sci Data","first-page":"305","article-title":"A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region","volume":"7","author":"Neudorfer C","year":"2020","unstructured":"Neudorfer C, Germann J, Elias GJB, Gramer R, Boutet A, Lozano AM. A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region. Sci Data. 2020;7(1):305. doi:10.1038\/s41597-020-00644-6"},{"issue":"4","key":"b13","series-title":"Brain Behav","first-page":"e00943","article-title":"Thalamic functional connectivity and its association with behavioral performance in older age","volume":"8","author":"Goldstone A","year":"2018","unstructured":"Goldstone A, Mayhew SD, Hale JR, Wilson RS, Bagshaw AP. Thalamic functional connectivity and its association with behavioral performance in older age. Brain Behav. 2018;8(4):e00943. doi:10.1002\/brb3.943"},{"key":"b14","series-title":"Neuroimage","first-page":"120451","article-title":"Transcriptional correlates of frequency-dependent brain functional activity associated with symptom severity in degenerative cervical myelopathy","volume":"284","author":"Guo X","year":"2023","unstructured":"Guo X, Li J, Su Q,  Transcriptional correlates of frequency-dependent brain functional activity associated with symptom severity in degenerative cervical myelopathy. Neuroimage. 2023;284:120451. doi:10.1016\/j.neuroimage.2023.120451"},{"key":"b15","series-title":"Handb Clin Neurol","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/B978-0-12-819975-6.00005-4","article-title":"Resting-state functional connectivity of the human hypothalamus","volume":"179","author":"Kullmann S","year":"2021","unstructured":"Kullmann S, Veit R. Resting-state functional connectivity of the human hypothalamus. Handb Clin Neurol. 2021;179:113\u2013124. doi:10.1016\/B978-0-12-819975-6.00005-4"},{"issue":"1","key":"b16","series-title":"Acta Psychiatr Scand","first-page":"56","article-title":"Hypothalamus enlargement in mood disorders","volume":"139","author":"Schindler S","year":"2019","unstructured":"Schindler S, Schmidt L, Stroske M,  Hypothalamus enlargement in mood disorders. Acta Psychiatr Scand. 2019;139(1):56\u201367. doi:10.1111\/acps.12958"},{"issue":"1","key":"b17","series-title":"eNeuro","first-page":"ENEURO.0377","article-title":"Upregulation of supplementary motor area activation with fMRI neurofeedback during motor imagery","volume":"8","author":"Al-Wasity S","year":"2021","unstructured":"Al-Wasity S, Vogt S, Vuckovic A, Pollick FE. 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Sci Rep. 2022;12(1):3570. doi:10.1038\/s41598-022-06519-7"},{"issue":"4","key":"b19","series-title":"Brain","first-page":"1542","article-title":"Supplementary motor area driving changes of structural brain network in blepharospasm","volume":"146","author":"Xu J","year":"2023","unstructured":"Xu J, Luo Y, Peng K,  Supplementary motor area driving changes of structural brain network in blepharospasm. Brain. 2023;146(4):1542\u20131553. doi:10.1093\/brain\/awac341"},{"issue":"1","key":"b20","series-title":"Sci Rep","first-page":"7245","article-title":"Metabolic profile of complete spinal cord injury in pons and cerebellum: a 3T 1H MRS study","volume":"13","author":"Richter JK","year":"2023","unstructured":"Richter JK, Vallesi V, Z\u00f6lch N,  Metabolic profile of complete spinal cord injury in pons and cerebellum: a 3T 1H MRS study. Sci Rep. 2023;13(1):7245. doi:10.1038\/s41598-023-34326-1"},{"key":"b21","series-title":"Front Neurosci","first-page":"914549","article-title":"Cerebellum regulating cerebral functional cortex through multiple pathways in complete thoracolumbar spinal cord injury","volume":"16","author":"Zheng W","year":"2022","unstructured":"Zheng W, Wang L, Yang B,  Cerebellum regulating cerebral functional cortex through multiple pathways in complete thoracolumbar spinal cord injury. Front Neurosci. 2022;16:914549. doi:10.3389\/fnins.2022.914549"},{"issue":"3","key":"b22","series-title":"Eur Neuropsychopharmacol","first-page":"239","article-title":"Replicated association of Synaptotagmin (SYT1) with ADHD and its broader influence in externalizing behaviors","volume":"27","author":"Cupertino RB","year":"2017","unstructured":"Cupertino RB, Schuch JB, Bandeira CE,  Replicated association of Synaptotagmin (SYT1) with ADHD and its broader influence in externalizing behaviors. Eur Neuropsychopharmacol. 2017;27(3):239\u2013247. doi:10.1016\/j.euroneuro.2017.01.007"},{"issue":"6","key":"b23","series-title":"Curr Protein Pept Sci","first-page":"470","article-title":"Synaptotagmin-1: a multi-functional protein that mediates vesicle docking, priming, and fusion","volume":"22","author":"Ullah N","year":"2021","unstructured":"Ullah N, Maaiden EE, Uddin MS, Ashraf GM. Synaptotagmin-1: a multi-functional protein that mediates vesicle docking, priming, and fusion. Curr Protein Pept Sci. 2021;22(6):470\u2013478. doi:10.2174\/1389203722666210325110231"},{"issue":"2","key":"b24","series-title":"J Neurochem","first-page":"177","article-title":"The role of myosin V in exocytosis and synaptic plasticity","volume":"116","author":"Rudolf R","year":"2011","unstructured":"Rudolf R, Bittins CM, Gerdes HH. The role of myosin V in exocytosis and synaptic plasticity. J Neurochem. 2011;116(2):177\u2013191. doi:10.1111\/j.1471-4159.2010.07110.x"},{"key":"b25","series-title":"Annu Rev Physiol","first-page":"355","article-title":"Short-term synaptic plasticity","volume":"64","author":"Zucker RS","year":"2002","unstructured":"Zucker RS, Regehr WG. Short-term synaptic plasticity. Annu Rev Physiol. 2002;64:355\u2013405. doi:10.1146\/annurev.physiol.64.092501.114547"},{"issue":"1","key":"b26","series-title":"Nat Commun","first-page":"4120","article-title":"Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice","volume":"14","author":"Delignat-Lavaud B","year":"2023","unstructured":"Delignat-Lavaud B, Kano J, Ducrot C,  Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice. 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J Neurosci Res. 1999;58(1):120\u2013129. doi:10.1002\/(SICI)1097-4547(19991001)58:1<120::AID-JNR12>3.0.CO;2-E"},{"issue":"1","key":"b29","series-title":"Nat Commun","first-page":"1647","article-title":"Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures","volume":"12","author":"Li J","year":"2021","unstructured":"Li J, Seidlitz J, Suckling J,  Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures. Nat Commun. 2021;12(1):1647. doi:10.1038\/s41467-021-21943-5"},{"issue":"9","key":"b30","series-title":"Alzheimers Dement","first-page":"6045","article-title":"Association of cortical morphology, white matter hyperintensity, and glymphatic function in frontotemporal dementia variants","volume":"20","author":"Xiao D","year":"2024","unstructured":"Xiao D, Li J, Ren Z,  Association of cortical morphology, white matter hyperintensity, and glymphatic function in frontotemporal dementia variants. Alzheimers Dement. 2024;20(9):6045\u20136059. doi:10.1002\/alz.14158"},{"issue":"2","key":"b31","series-title":"Addict Biol","first-page":"209","article-title":"Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury","volume":"17","author":"Prendergast MA","year":"2012","unstructured":"Prendergast MA, Mulholland PJ. Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury. Addict Biol. 2012;17(2):209\u2013223. doi:10.1111\/j.1369-1600.2011.00375.x"},{"issue":"1","key":"b32","series-title":"NPJ Regen Med","first-page":"22","article-title":"Neuronal activation in the axolotl brain promotes tail regeneration","volume":"10","author":"Walker SE","year":"2025","unstructured":"Walker SE, Yu K, Burgess S, Echeverri K. Neuronal activation in the axolotl brain promotes tail regeneration. NPJ Regen Med. 2025;10(1):22. doi:10.1038\/s41536-025-00413-2"},{"issue":"7936","key":"b33","series-title":"Nature","first-page":"540","article-title":"The neurons that restore walking after paralysis","volume":"611","author":"Kathe C","year":"2022","unstructured":"Kathe C, Skinnider MA, Hutson TH,  The neurons that restore walking after paralysis. Nature. 2022;611(7936):540\u2013547. doi:10.1038\/s41586-022-05385-7"},{"issue":"6664","key":"b34","series-title":"Science","first-page":"1338","article-title":"Recovery of walking after paralysis by regenerating characterized neurons to their natural target region","volume":"381","author":"Squair JW","year":"2023","unstructured":"Squair JW, Milano M, de Coucy A,  Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science. 2023;381(6664):1338\u20131345. doi:10.1126\/science.adi6412"},{"issue":"8019","key":"b35","series-title":"Nature","first-page":"150","article-title":"Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica","volume":"631","author":"Skinnider MA","year":"2024","unstructured":"Skinnider MA, Gautier M, Teo AYY,  Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica. 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Sci Rep. 2022;12(1):19584. doi:10.1038\/s41598-022-23855-w"},{"key":"b38","series-title":"bioRxiv","article-title":"Human spinal interneurons repair the injured spinal cord through synaptic integration","author":"Zholudeva LV","unstructured":"Zholudeva LV, Fortino T, Agrawal A,  Human spinal interneurons repair the injured spinal cord through synaptic integration. bioRxiv. Preprint published online January 12, 2024. doi:10.1101\/2024.01.11.575264"},{"issue":"12","key":"b39","series-title":"Nat Neurosci","first-page":"1584","article-title":"Natural and targeted circuit reorganization after spinal cord injury","volume":"25","author":"Anderson MA","year":"2022","unstructured":"Anderson MA, Squair JW, Gautier M,  Natural and targeted circuit reorganization after spinal cord injury. 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