{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:22:53Z","timestamp":1794327773100,"version":"4.9.0"},"reference-count":42,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>\n                      In light of microRNA (miRNA)\u2013targeted therapies in the management of intervertebral disc degeneration (IVDD), this study aimed to elucidate the role and mechanism of miRNA\n                      <jats:italic>(miR)\u2013148a-3p<\/jats:italic>\n                      in the pathogenesis of IVDD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Human nucleus pulposus (NP) cells treated with interleukin (IL)\u20131\u03b2 (10 ng\/mL) were used to simulate IVDD in vitro. Gain-of-function experiments were performed by transfecting NP cells with an\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      mimic and a pcDNA\u2013epidermal growth factor receptor (EGFR) vector (a mammalian expression encoding EGFR) and evaluated using the CCK-8 assay and TUNEL staining. The target of\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      was identified by a dual-luciferase reporter assay. An in vivo IVDD model was established using Sprague-Dawley rats subjected to acupuncture, followed by histological, inflammatory, and expression analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Downregulation of\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      but upregulation of EGFR was observed in IL-1\u03b2\u2013treated NP cells. Increasing\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      resulted in elevated cell viability but decreased apoptosis in IL-1\u03b2\u2013treated NP cells. Meanwhile, the upregulation of\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      effectively counteracted all IL-1\u03b2\u2013induced alterations in protein expression, as demonstrated by the enhanced expression of extracellular matrix (ECM)\u2013associated markers, alongside a reduction in autophagy markers such as LC3II\/LC3I, Beclin1, and ATG7.\n                      <jats:italic>MiR-148a-3p<\/jats:italic>\n                      was found to exert a negative regulatory effect on EGFR. The overexpression of EGFR negated the alterations induced by the\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      mimic. In the IVDD rat model,\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      ameliorated histological damage and enhanced ECM marker expression while concurrently reducing the inflammatory response and autophagy markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      The restoration of\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      inhibited EGFR, thereby suppressing inflammation, apoptosis, and autophagy but promoting ECM production in IVDD models. Therefore,\n                      <jats:italic>miR-148a-3p<\/jats:italic>\n                      may serve as a potential therapeutic candidate for the management of IVDD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.12.spine251314","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:39:17Z","timestamp":1779359957000},"page":"105-116","source":"Crossref","is-referenced-by-count":1,"title":["Targeting EGFR with miR-148a-3p: a novel approach to mitigate intervertebral disc degeneration"],"prefix":"10.3171","volume":"45","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Graduate School, Shenyang Medical College, Shenyang, Liaoning, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Weihaiwei People\u2019s Hospital, Weihai, Shandong, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Sun","sequence":"additional","affiliation":[{"name":"Graduate School, Shenyang Medical College, Shenyang, Liaoning, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Asian Spine J","first-page":"245","article-title":"Significance of the association between disc degeneration changes on imaging and low back pain: a review article","volume":"14","author":"Rahyussalim AJ","year":"2020","unstructured":"Rahyussalim AJ, Zufar MLL, Kurniawati T. 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