{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:33:45Z","timestamp":1787499225322,"version":"build-2736575974"},"reference-count":46,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Endoscopic third ventriculostomy (ETV) is advocated as a shunt-free alternative for managing hydrocephalus to mitigate the complications associated with ventriculoperitoneal shunt (VPS). However, its efficacy in treating pediatric tuberculous meningitis\u2013related hydrocephalus (TBMH) remains uncertain. The authors\u2019 review aimed to evaluate the safety and effectiveness of ETV compared to VPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The authors searched PubMed, Embase, and Cochrane for articles comparing ETV with VPS in the pediatric population. They included studies evaluated success rate, mortality, postprocedural complications, and infections. A random-effects model was used, with heterogeneity assessed with I\n                      <jats:sup>2<\/jats:sup>\n                      and sensitivity analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A pooled analysis of 369 patients from 5 studies (2 randomized controlled trials and 3 observational studies), including 162 patients who underwent ETV and 207 VPS, revealed no significant difference in the success rates between ETV and VPS for TBMH (OR 0.72, 95% CI 0.45\u20131.14, p = 0.159, I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%). Furthermore, no significant differences in the postoperative complication (OR 0.59, 95% CI 0.08\u20134.17, p = 0.599, I\n                      <jats:sup>2<\/jats:sup>\n                      = 75%), mortality (OR 0.78, 95% CI 0.23\u20132.65, p = 0.684, I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%), or infection (OR 0.52, 95% CI 0.09\u20132.87, I\n                      <jats:sup>2<\/jats:sup>\n                      = 11%) rates were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The authors\u2019 meta-analysis shows no significant differences in success rates, mortality risk, and incidence of complications and infections between ETV and VPS for children with TBMH. However, the broad confidence intervals and limited number of included studies introduce significant uncertainty. Therefore, while no statistically significant differences have been demonstrated, the equivalence of these treatments cannot be conclusively affirmed, and the potential for clinically significant differences remains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.2.peds24441","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T22:49:49Z","timestamp":1749250189000},"page":"296-303","source":"Crossref","is-referenced-by-count":4,"title":["Endoscopic third ventriculostomy versus ventriculoperitoneal shunt for treating pediatric tuberculous meningitis hydrocephalus: a systematic review and meta-analysis"],"prefix":"10.3171","volume":"36","author":[{"given":"Walter","family":"Fagundes","sequence":"first","affiliation":[{"name":"Neurosurgery Department, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Geneuro\u2013International Research Group in Neuroscience, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha R.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Medical and Dental College, Karachi, Sindh, Pakistan;"},{"name":"Geneuro\u2013International Research Group in Neuroscience, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Healthcare Institution of South Iceland, Selfoss, Iceland;"},{"name":"Geneuro\u2013International Research Group in Neuroscience, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"\u0141ajczak","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Silesia, Poland;"},{"name":"Geneuro\u2013International Research Group in Neuroscience, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helv\u00e9cio N.","family":"Feitosa Filho","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Fortaleza, Fortaleza, Cear\u00e1, Brazil;"},{"name":"Geneuro\u2013International Research Group in Neuroscience, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshita","family":"Sharma","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, UCLA, Los Angeles, California;"},{"name":"Geneuro\u2013International Research Group in Neuroscience, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Richard S.","family":"Oliveira Filho","sequence":"additional","affiliation":[{"name":"Medical Sciences Center, Federal University of Para\u00edba, Jo\u00e3o Pessoa, Para\u00edba, Brazil;"},{"name":"Geneuro\u2013International Research Group in Neuroscience, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela O.","family":"M\u00f4ro","sequence":"additional","affiliation":[{"name":"School of Sciences of Santa Casa de Miseric\u00f3rdia Hospital, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Geneuro\u2013International Research Group in Neuroscience, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo B. O.","family":"Brenner","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa, Ponta Grossa, Paran\u00e1, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"5","key":"b1","series-title":"Cureus","first-page":"e25317","article-title":"The outcome of surgical intervention (ventriculoperitoneal shunt and endoscopic third ventriculostomy) in patients with hydrocephalus secondary to tuberculous meningitis: a systematic review","volume":"14","author":"Chalasani R","year":"2022","unstructured":"Chalasani R, Goonathilake MR, Waqar S,  The outcome of surgical intervention (ventriculoperitoneal shunt and endoscopic third ventriculostomy) in patients with hydrocephalus secondary to tuberculous meningitis: a systematic review. 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