{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:00:47Z","timestamp":1784296847930,"version":"3.55.0"},"reference-count":76,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the relationship between the clinical and radiological characteristics of olfactory groove meningiomas (OGMs) and their molecular profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors performed targeted next-generation and whole-genome sequencing in 123 OGM samples collected from 4 international institutions, focusing on known meningioma-driver genes. They compared the molecular data with the clinical and radiographic features of the tumors. Patient and tumor data, including age, sex, radiological features, and overall survival, were retrospectively collected and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The study cohort comprised 90 females (73%) and 33 males (27%), with a median age at diagnosis of 57 years (range 25\u201387 years). The majority of tumors (88.6%, n = 109) were classified as WHO grade I meningioma. Known driver mutations were found in 86.2% of patients (n = 106), with the most common mutations found in the\n                      <jats:italic>\n                        SMO\n                        <jats:sup>L412F\/W535L<\/jats:sup>\n                      <\/jats:italic>\n                      and\n                      <jats:italic>\n                        AKT1\n                        <jats:sup>E17K<\/jats:sup>\n                      <\/jats:italic>\n                      genes, each present in 36 cases (29.3%), followed by mutations in\n                      <jats:italic>PIK3CA<\/jats:italic>\n                      \/\n                      <jats:italic>PIK3R1<\/jats:italic>\n                      (19 cases, 15.4%; 14\n                      <jats:italic>PIK3CA<\/jats:italic>\n                      and 5\n                      <jats:italic>PIK3R1<\/jats:italic>\n                      ),\n                      <jats:italic>TRAF7<\/jats:italic>\n                      alone (7 cases, 5.7%),\n                      <jats:italic>\n                        POLR2A\n                        <jats:sup>Q403K<\/jats:sup>\n                      <\/jats:italic>\n                      (4 cases, 3.3%), and\n                      <jats:italic>TRAF7<\/jats:italic>\n                      \/\n                      <jats:italic>\n                        KLF4\n                        <jats:sup>K409Q<\/jats:sup>\n                      <\/jats:italic>\n                      (3 cases, 2.4%), while 17 patients (13.8%) did not harbor known meningioma driver mutations (wildtype group). Within molecular subgroups, patients with\n                      <jats:italic>AKT1<\/jats:italic>\n                      mutations were the youngest (median age 51 years, range 30\u201387 years) and patients with\n                      <jats:italic>TRAF7<\/jats:italic>\n                      -only mutations were the oldest (median 66 years, range 28\u201376 years). The median tumor volume at diagnosis was 18.04 cm\n                      <jats:sup>3<\/jats:sup>\n                      .\n                      <jats:italic>SMO<\/jats:italic>\n                      -mutant tumors were significantly larger (median volume 19.5 cm\n                      <jats:sup>3<\/jats:sup>\n                      ) than both\n                      <jats:italic>AKT1<\/jats:italic>\n                      -mutant (median 7.5 cm\n                      <jats:sup>3<\/jats:sup>\n                      , p = 0.021) and\n                      <jats:italic>TRAF7\/KLF4<\/jats:italic>\n                      -mutant (median 4.9 cm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:sup\/>\n                      p = 0.002) tumors. Tumor-associated hyperostosis of the sphenoid planum was common (58.5%), led by\n                      <jats:italic>PIK3CA<\/jats:italic>\n                      \/\n                      <jats:italic>PIK3R1, SMO<\/jats:italic>\n                      , and wildtype groups (73.7%, 72.2%, and 70.6%, respectively), compared with a notably lower rate in\n                      <jats:italic>AKT1<\/jats:italic>\n                      -mutant tumors (25%) (p &lt; 0.001). Tumor invasion of the ethmoid sinuses occurred most frequently in the\n                      <jats:italic>TRAF7<\/jats:italic>\n                      -only mutant OGMs (42.9%), followed by\n                      <jats:italic>PIK3CA\/PIK3R1<\/jats:italic>\n                      -mutant (31.6%) and wildtype (23.5%) OGMs. The mean progression-free survival (PFS) was 144.4 months (95% CI 123.8\u2013165 months). Patients with\n                      <jats:italic>SMO<\/jats:italic>\n                      -mutant OGMs exhibited a significantly shorter mean PFS of 92.0 months (95% CI 70.1\u2013113.9 months) compared with 158.2 months (95% CI 134.9\u2013181.5 months) for\n                      <jats:italic>SMO<\/jats:italic>\n                      -wildtype OGMs (p = 0.004), identifying a tumor type that might benefit from adjuvant treatment after resection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      This study revealed that 70% of OGMs harbor\n                      <jats:italic>SMO, AKT1<\/jats:italic>\n                      , and\n                      <jats:italic>PIK3CA<\/jats:italic>\n                      mutations, influencing tumor behavior, symptoms, and outcomes, supporting molecular profiling for personalized treatment in OGM management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.4.jns242619","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T01:41:14Z","timestamp":1757122874000},"page":"1458-1466","source":"Crossref","is-referenced-by-count":1,"title":["Molecular landscape and clinical correlates of olfactory groove meningiomas: a multi-institutional study"],"prefix":"10.3171","volume":"143","author":[{"given":"Majd","family":"Alkhatib","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyang","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insa","family":"Prilop","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino","family":"Podlesek","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeeva","family":"Jeyaretna","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, John Radcliffe Hospital, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Fujio","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kagoshima University, Kagoshima, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Zolal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berfin","family":"Cicek","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, 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P.","family":"Cahill","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuro-Oncology, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Wakimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuro-Oncology, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bristol Royal Infirmary, Bristol, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pinzer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Schackert","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker Y.","family":"Ey\u00fcpoglu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus, TU Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla K.","family":"Brastianos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, 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