{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:26:55Z","timestamp":1772724415787,"version":"3.50.1"},"reference-count":78,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The endonasal endoscopic transsphenoidal approach (ETA) is the standard approach for pituitary adenomas (PAs). Chronic sinusitis is a prevalent condition affecting 2%\u201315% of the general population. However, the impact of preoperative sinusitis on the outcomes of ETA for PA remains unknown. This study investigated the impact of preoperative sinusitis on the outcomes of ETA for PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective cohort analysis was conducted using the TriNetX database. Propensity score matching (PSM) was performed to form two balanced groups to compare patients with and without preoperative chronic sinusitis who underwent subsequent ETA for PAs. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the TriNetX platform to compare the perioperative and neuroendocrine outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The crude cohort included a total of 10,675 patients. After PSM, 842 patients were included in both the sinusitis and nonsinusitis groups. The mean age at ETA was 54.3 and 55.0 years in the sinusitis and nonsinusitis groups, respectively. Compared to the nonsinusitis group, patients in the sinusitis group had a higher incidence of postoperative CSF leakage (OR 1.47, 95% CI 1.06\u20132.03; p = 0.021), meningitis (OR 2.47, 95% CI 1.25\u20134.87; p = 0.007), postoperative diabetes insipidus (DI) (OR 1.47, 95% CI 1.17\u20131.83; p = 0.001), desmopressin use (OR 1.77, 95% CI 1.34\u20132.33; p = 0.001), and steroid use (OR 1.46, 95% CI 1.15\u20131.85; p = 0.002). Sensitivity analysis demonstrated consistent results across the different matching models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In patients who underwent ETA for PAs, preoperative sinusitis was associated with an increased risk of postoperative CSF leakage, meningitis, DI, desmopressin use, and steroid use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.4.jns243094","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T01:34:48Z","timestamp":1754703288000},"page":"169-177","source":"Crossref","is-referenced-by-count":0,"title":["Impact of preoperative sinusitis on surgical outcomes in patients with pituitary adenoma undergoing endoscopic transsphenoidal surgery: a real-world population-based cohort study"],"prefix":"10.3171","volume":"144","author":[{"given":"Chia-En","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan;"},{"name":"Center of Transformative Bioelectronic Medicine, National Cheng Kung University, Tainan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Ta","family":"Huang","sequence":"additional","affiliation":[{"name":"Surgical Intensive Care Unit, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng-Jui","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chiayi Christian Hospital, Chiayi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng-Juei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tainan Municipal Hospital (managed by Show Chwan Medical Care Corporation), Tainan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Shun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan;"},{"name":"Center of Transformative Bioelectronic Medicine, National Cheng Kung University, Tainan;"},{"name":"Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan; and"},{"name":"Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"5","key":"b1","series-title":"Biomedicines","first-page":"494","article-title":"Pituitary adenomas: from diagnosis to therapeutics","volume":"9","author":"Banskota S","year":"2021","unstructured":"Banskota S, Adamson DC. Pituitary adenomas: from diagnosis to therapeutics. Biomedicines. 2021;9(5)494."},{"issue":"4","key":"b2","series-title":"J Clin Med","first-page":"955","article-title":"Current and emerging medical therapies in pituitary tumors","volume":"11","author":"Sahakian N","year":"2022","unstructured":"Sahakian N, Castinetti F, Brue T, Cuny T. Current and emerging medical therapies in pituitary tumors. J Clin Med. 2022;11(4)955."},{"issue":"6","key":"b3","series-title":"Pituitary","first-page":"930","article-title":"Complication avoidance protocols in endoscopic pituitary adenoma surgery: a retrospective cohort study in 514 patients","volume":"24","author":"Thakur JD","year":"2021","unstructured":"Thakur JD, Corlin A, Mallari RJ,  Complication avoidance protocols in endoscopic pituitary adenoma surgery: a retrospective cohort study in 514 patients. Pituitary. 2021; 24(6):930\u2013942."},{"issue":"3","key":"b4","series-title":"J Neurosurg","first-page":"627","article-title":"Comparative analysis of outcomes following craniotomy and expanded endoscopic endonasal transsphenoidal resection of craniopharyngioma and related tumors: a single-institution study","volume":"124","author":"Jeswani S","year":"2016","unstructured":"Jeswani S, Nu\u00f1o M, Wu A,  Comparative analysis of outcomes following craniotomy and expanded endoscopic endonasal transsphenoidal resection of craniopharyngioma and related tumors: a single-institution study. 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J Clin Med. 2022;11(4)955."},{"issue":"6","key":"b3","series-title":"Pituitary","first-page":"930","article-title":"Complication avoidance protocols in endoscopic pituitary adenoma surgery: a retrospective cohort study in 514 patients","volume":"24","author":"Thakur JD","year":"2021","unstructured":"Thakur JD, Corlin A, Mallari RJ,  Complication avoidance protocols in endoscopic pituitary adenoma surgery: a retrospective cohort study in 514 patients. Pituitary. 2021; 24(6):930\u2013942."},{"issue":"3","key":"b4","series-title":"J Neurosurg","first-page":"627","article-title":"Comparative analysis of outcomes following craniotomy and expanded endoscopic endonasal transsphenoidal resection of craniopharyngioma and related tumors: a single-institution study","volume":"124","author":"Jeswani S","year":"2016","unstructured":"Jeswani S, Nu\u00f1o M, Wu A,  Comparative analysis of outcomes following craniotomy and expanded endoscopic endonasal transsphenoidal resection of craniopharyngioma and related tumors: a single-institution study. 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Egypt J Otolaryngol. 2017; 33(1):20\u201323."},{"issue":"4","key":"b7","series-title":"Otolaryngol Head Neck Surg","first-page":"573","article-title":"Preoperative treatment with topical corticoids and bleeding during primary endoscopic sinus surgery","volume":"143","author":"Albu S","year":"2010","unstructured":"Albu S, Gocea A, Mitre I. Preoperative treatment with topical corticoids and bleeding during primary endoscopic sinus surgery. Otolaryngol Head Neck Surg. 2010;143(4):573\u2013578."},{"issue":"7","key":"b8","series-title":"Diagnostics (Basel)","first-page":"758","article-title":"Risk factors for isolated sphenoid sinusitis after endoscopic endonasal transsphenoidal pituitary surgery","volume":"14","author":"Chang YC","year":"2024","unstructured":"Chang YC, Tsao YN, Chuang CC,  Risk factors for isolated sphenoid sinusitis after endoscopic endonasal transsphenoidal pituitary surgery. 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Arch Otolaryngol Head Neck Surg. 2006;132(9):969\u2013976."},{"key":"b27","series-title":"Allergy Rhinol (Providence)","first-page":"2152656721996258","article-title":"Neurological complications of acute rhinosinusitis: meningitis","volume":"12","author":"Bennett S","year":"2021","unstructured":"Bennett S, Meghji S, Syeda F, Bhat N. Neurological complications of acute rhinosinusitis: meningitis. Allergy Rhinol (Providence). 2021;12:2152656721996258."},{"issue":"6","key":"b28","series-title":"Article in Chinese. Xiandai Shengwu Yixue Jinzhan","first-page":"1128","article-title":"Analysis of risk factors on cerebrospinal fluid rhinorrhea after the treatment of giant pituitary adenomas by transsphenoidal surgery","author":"Yu J","year":"2014","unstructured":"Yu J, Zhao Y, Wang Y, Zhang G, Gao D, Zheng X. Analysis of risk factors on cerebrospinal fluid rhinorrhea after the treatment of giant pituitary adenomas by transsphenoidal surgery. Article in Chinese. 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World Neurosurg. 2017;101:1\u201310."},{"issue":"3","key":"b33","series-title":"J Neurosurg","first-page":"647","article-title":"Identifying risk factors for postoperative diabetes insipidus in more than 2500 patients undergoing transsphenoidal surgery: a single-institution experience","volume":"137","author":"Joshi RS","year":"2022","unstructured":"Joshi RS, Pereira MP, Osorio RC,  Identifying risk factors for postoperative diabetes insipidus in more than 2500 patients undergoing transsphenoidal surgery: a single-institution experience. J Neurosurg. 2022;137(3):647\u2013657."},{"key":"b34","series-title":"Front Neurol","first-page":"843646","article-title":"Predicting the need for desmopressin treatment during inpatient and after discharge following endoscopic sellar surgery","volume":"13","author":"Wong CE","year":"2022","unstructured":"Wong CE, Wang WH, Lan MY,  Predicting the need for desmopressin treatment during inpatient and after discharge following endoscopic sellar surgery. 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Curr Allergy Asthma Rep. 2016;16(1):3."},{"issue":"5","key":"b37","series-title":"Int Forum Allergy Rhinol","first-page":"458","article-title":"Correlation between systemic inflammatory response and quality of life in patients with chronic rhinosinusitis","volume":"9","author":"Orb Q","year":"2019","unstructured":"Orb Q, Pulsipher A, Smith KA, Ashby S, Alt JA. Correlation between systemic inflammatory response and quality of life in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019;9(5):458\u2013465."},{"key":"b38","series-title":"Front Neurosci","first-page":"649485","article-title":"The function of the hypothalamic\u2013pituitary\u2013adrenal axis during experimental autoimmune encephalomyelitis: involvement of oxidative stress mediators","volume":"15","author":"Trifunovic S","year":"2021","unstructured":"Trifunovic S, Stevanovic I, Milosevic A,  The function of the hypothalamic\u2013pituitary\u2013adrenal axis during experimental autoimmune encephalomyelitis: involvement of oxidative stress mediators. Front Neurosci. 2021;15:649485."},{"issue":"1","key":"b39","series-title":"Endocrine","first-page":"196","article-title":"Association between thyroid function and serum cortisol in cortisol-producing adenoma patients","volume":"69","author":"Cai R","year":"2020","unstructured":"Cai R, Zhou W, Jiang L,  Association between thyroid function and serum cortisol in cortisol-producing adenoma patients. 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