{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:58:30Z","timestamp":1772827110542,"version":"3.50.1"},"reference-count":54,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,24]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Prior studies on spinal ependymoma typically group patients based on tumor pathology, often combining myxopapillary ependymomas and other ependymoma subtypes into a single cohort. This study aimed to evaluate differences in patient presentation and long-term functional outcomes between cervical\/thoracic and conus\/filum ependymomas. The authors hypothesized that these variations are location specific and warrant further stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The medical records of adult patients who underwent resection for spinal ependymoma at a single tertiary-care institution between 2006 and 2023 were retrospectively reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 146 patients with pathologically confirmed spinal ependymoma were included, with a mean follow-up of 2.2 \u00b1 3.1 years. The cohort was divided into two groups: cervical\/thoracic ependymomas (n = 101) and conus\/filum ependymomas (n = 45). The tumors in the cervical\/thoracic group were predominantly located in the cervical region (68.3%) and were intramedullary (100%), while the conus\/filum group tumors were mostly found in the lumbar region (88.9%) and were primarily extramedullary (86.7%) (p &lt; 0.001). Preoperative symptoms varied significantly between the two groups. Sensory disturbances were more common in the cervical\/thoracic group (82.2% vs 40%, p &lt; 0.001), while pain was more frequent in the conus\/filum group (95.6% vs 74.3%, p = 0.003). Preoperative weakness was significantly more prevalent in the cervical\/thoracic group (49.5% vs 20.0%, p &lt; 0.001), and gait instability was also more common in this intramedullary group (p = 0.03). A higher proportion of patients in the cervical\/thoracic group required nonhome discharge (35.7% vs 8.9%, p = 0.003). At the last follow-up, sensory deficits were more prevalent in the cervical\/thoracic group (57.4% vs 11.1%, p &lt; 0.001), while functional independence was significantly higher in the conus\/filum group (95.6% vs 90.1%, p &lt; 0.001). Multivariable analysis revealed that female sex, non-White race, and lumbar tumor location were significant predictors of pain at last follow-up. Additionally, the presence of a conus\/filum tumor was associated with significantly lower odds of sensory disturbances at last follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The authors\u2019 data demonstrate that tumor location significantly influences symptom presentation, functional improvement over time, and overall outcomes, highlighting the importance of location-based stratification in future research and treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.6.spine25209","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T20:52:47Z","timestamp":1763412767000},"page":"262-271","source":"Crossref","is-referenced-by-count":0,"title":["Presenting symptoms and outcomes of cervical and thoracic ependymomas compared to conus and filum ependymomas"],"prefix":"10.3171","volume":"44","author":[{"given":"FNU","family":"Ruchika","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Karim","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel-Hameed","family":"Al-Mistarehi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Rajasekaran","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"},{"name":"Department of Neurosurgery, Drexel University College of Medicine, Philadelphia, Pennsylvania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Derin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan","family":"Bettegowda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Sciubba","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, North Shore University Hospital\/Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Manhasset, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Fu Larry","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, North Shore University Hospital\/Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Manhasset, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Bydon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Witham","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Theodore","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Jallo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin J.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"},{"name":"Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence R.","family":"Kleinberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"},{"name":"Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lubelski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Aging Dis","first-page":"468","article-title":"Roles of ependymal cells in the physiology and pathology of the central nervous system","volume":"14","author":"Deng S","year":"2023","unstructured":"Deng S, Gan L, Liu C,  Roles of ependymal cells in the physiology and pathology of the central nervous system. 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