{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:56:16Z","timestamp":1781794576519,"version":"3.54.5"},"reference-count":54,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Despite advances in technical approaches, microsurgical resection remains the gold standard for treating drug-resistant mesial temporal lobe epilepsy (MTLE). However, current multicenter data on the risk of new focal neurological deficits following MTLE surgery and on factors predicting the likelihood of seizure freedom postsurgery are limited. This study aimed to evaluate the safety and efficacy of surgery by providing reliable data on the predictors of favorable postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors conducted a retrospective multicenter analysis across 20 epilepsy centers on 5 continents. Detailed standardized clinical data were collected, encompassing the preoperative status of patients, presurgical diagnostics, surgical techniques, complications, and neurological outcomes. Predictive factors for postoperative neurological deficits and a satisfactory response to surgery (defined as International League Against Epilepsy [ILAE] classes 1 and 2) were analyzed using a logistic regression model. Additionally, the authors assessed the relationship between neurological deficits, seizure outcomes, and neuropsychological performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 1167 patients were included in this study. Postoperative new neurological deficits were observed in 22.2% of cases, with new quadrantanopia being the most common (11.2%). No in-hospital mortality or 30-day mortality was recorded. Surgical revision was necessary in 4.3% of cases within the 1st year. A younger age and surgical intervention on the nondominant brain hemisphere were associated with a reduced risk of postoperative neurological deficits. After 1 year, 74.2% of patients achieved seizure outcomes classified as ILAE class 1 or 2. Known positive predictors of seizure outcomes, such as identifiable MRI lesions and a history of febrile seizures, were supported by data. Furthermore, even after adjusting for preoperative MRI findings, hemisphere dominance, occurrence of bilateral tonic-clonic seizures, age, and sex, anterior temporal lobe resection was linked to improved seizure outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This study offers extensive multicenter data on outcomes following MTLE surgery from a large international patient cohort. The authors\u2019 analysis indicates a strong safety profile and high efficacy for epilepsy surgery in this patient group. The comprehensive breakdown of results facilitates the assessment of individual success prospects and improves informed patient counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2025.8.jns243031","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:40:09Z","timestamp":1769218809000},"page":"1359-1368","source":"Crossref","is-referenced-by-count":0,"title":["Safety in epilepsy surgery: a multicenter analysis of surgery-related complications and seizure outcome in 1167 cases of mesial temporal lobe epilepsy"],"prefix":"10.3171","volume":"144","author":[{"given":"Tobias","family":"Pantel","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Drexler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharona","family":"Ben-Haim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, San Diego, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rada","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara), Medical School, Bielefeld University, Bielefeld;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich G.","family":"Woermann","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara), Medical School, Bielefeld University, Bielefeld;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cloppenborg","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara), Medical School, Bielefeld University, Bielefeld;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian G.","family":"Bien","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara), Medical School, Bielefeld University, Bielefeld;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara), Medical School, Bielefeld University, Bielefeld;"},{"name":"Department of Neurosurgery (Evangelisches Klinikum Bethel), Medical School, Bielefeld University, Bielefeld, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Kalbhenn","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara), Medical School, Bielefeld University, Bielefeld;"},{"name":"Department of Neurosurgery (Evangelisches Klinikum Bethel), Medical School, Bielefeld University, Bielefeld, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Colon","sequence":"additional","affiliation":[{"name":"Department of Epileptology, Academic Center for Epileptology Kempenhaeghe, Heeze;"},{"name":"Hamburg Epilepsy Center, Protestant Hospital Alsterdorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Rijkers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Academic Center for Epileptology, UMC Maastricht University Medical Center, Maastricht;"},{"name":"Mental Health and Neuroscience Research Institute (MHeNS), Maastricht University, Maastricht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Schijns","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Academic Center for Epileptology, UMC Maastricht University Medical Center, Maastricht;"},{"name":"Mental Health and Neuroscience Research Institute (MHeNS), Maastricht University, Maastricht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeri","family":"Borger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Bonn;"},{"name":"Department of Epileptology, University Hospital Bonn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Surges","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Bonn;"},{"name":"Department of Epileptology, University Hospital Bonn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Vatter","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Bonn;"},{"name":"Department of Epileptology, University Hospital Bonn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Functional Neurosurgery Unit, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"de Curtis","sequence":"additional","affiliation":[{"name":"Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Didato","sequence":"additional","affiliation":[{"name":"Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f3","family":"Castelli","sequence":"additional","affiliation":[{"name":"Functional Neurosurgery Unit, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Mathon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa Lin","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Campinas, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Campinas, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Ghizoni","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Campinas, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poodipedi Sarat","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery & Neurology, AIIMS, & MEG Resource Facility, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery & Neurology, AIIMS, & MEG Resource Facility, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Clusmann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Guenot","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery, Hospital Pierre Wertheimer, Hospices Civils de Lyon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Haegelen","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery, Hospital Pierre Wertheimer, Hospices Civils de Lyon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Catenoix","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospices Civils de Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Lang","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology, University of Erlangen-N\u00fcrnberg, Erlangen;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajo","family":"Hamer","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology, University of Erlangen-N\u00fcrnberg, Erlangen;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Delev","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurosurgery, University of Erlangen-N\u00fcrnberg, Erlangen;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Walther","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology, University of Erlangen-N\u00fcrnberg, Erlangen;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, F\u00fcrth Hospital, F\u00fcrth, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S.","family":"Hauptman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind L.","family":"Jeffree","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Brisbane and Women\u2019s Hospital, Brisbane, Queensland, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josua","family":"Kegele","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of T\u00fcbingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Weinbrenner","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of T\u00fcbingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Naros","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of T\u00fcbingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Velz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus","family":"Krayenb\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Onken","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9 - Universit\u00e4tsmedizin Charit\u00e9-Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf C.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lucerne Cantonal Hospital, Lucerne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Holtkamp","sequence":"additional","affiliation":[{"name":"Institute for Diagnostics of Epilepsy, Epilepsy-Center Berlin-Brandenburg, Berlin;"},{"name":"Department of Neurology, Universit\u00e4tsmedizin Charit\u00e9-Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Spyrantis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Goethe University Frankfurt, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Strzelczyk","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Goethe University Frankfurt, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Rosenow","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Goethe University Frankfurt, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Stodieck","sequence":"additional","affiliation":[{"name":"Hamburg Epilepsy Center, Protestant Hospital Alsterdorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Voges","sequence":"additional","affiliation":[{"name":"Hamburg Epilepsy Center, Protestant Hospital Alsterdorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario A.","family":"Alonso-Vanegas","sequence":"additional","affiliation":[{"name":"National Institute of Neurology and Neurosurgery \"Manuel Velasco Suarez,\" Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Wellmer","sequence":"additional","affiliation":[{"name":"Ruhr-Epileptology, Department of Neurology, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Wehner","sequence":"additional","affiliation":[{"name":"Ruhr-Epileptology, Department of Neurology, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Buchert","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"D\u00fchrsen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz L.","family":"Ricklefs","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sauvigny","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"31","key":"b1","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"821","article-title":"National and state estimates of the numbers of adults and children with active epilepsy -","volume":"66","author":"Zack MM","year":"2015","unstructured":"Zack MM, Kobau R. National and state estimates of the numbers of adults and children with active epilepsy -. United States,2015.MMWR Morb Mortal Wkly Rep. 2017;66(31):821\u2013825."},{"issue":"1","key":"b2","series-title":"Epilepsia","first-page":"37","article-title":"Early versus late remission in a cohort of patients with newly diagnosed epilepsy","volume":"51","author":"Del Felice A","year":"2010","unstructured":"Del Felice A, Beghi E, Boero G,  Early versus late remission in a cohort of patients with newly diagnosed epilepsy. Epilepsia. 2010;51(1):37\u201342."},{"issue":"4","key":"b3","series-title":"Lancet Neurol","first-page":"344","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"23","year":"2024","unstructured":"Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024;23(4):344\u2013381."},{"issue":"5","key":"b4","series-title":"Neurosurgery","first-page":"676","article-title":"Seizure outcome of temporal lobe epilepsy surgery in adults and children: a systematic review and meta-analysis","volume":"91","author":"Barba C","year":"2022","unstructured":"Barba C, Giometto S, Lucenteforte E,  Seizure outcome of temporal lobe epilepsy surgery in adults and children: a systematic review and meta-analysis. Neurosurgery. 2022;91(5):676\u2013683."},{"issue":"Suppl 1","key":"b5","series-title":"Epilepsia.","first-page":"10","article-title":"Microsurgical techniques in temporal lobe epilepsy","volume":"58","author":"Alonso Vanegas MA","year":"2017","unstructured":"Alonso Vanegas MA, Lew SM, Morino M, Sarmento SA. Microsurgical techniques in temporal lobe epilepsy. Epilepsia. 2017;58 Suppl 1:10\u201318."},{"issue":"3","key":"b6","series-title":"JAMA","first-page":"285","article-title":"Resective epilepsy surgery for drug-resistant focal epilepsy: a review","volume":"313","author":"Jobst BC","year":"2015","unstructured":"Jobst BC, Cascino GD. Resective epilepsy surgery for drug-resistant focal epilepsy: a review. JAMA. 2015;313(3):285\u2013293."},{"key":"b7","series-title":"World Neurosurg","first-page":"639","article-title":"Complications after surgery for mesial temporal lobe epilepsy associated with hippocampal sclerosis","volume":"102","author":"Mathon B","year":"2017","unstructured":"Mathon B, Navarro V, Bielle F,  Complications after surgery for mesial temporal lobe epilepsy associated with hippocampal sclerosis. World Neurosurg. 2017;102:639\u2013650e2."},{"issue":"5","key":"b8","series-title":"J Neurosurg","first-page":"1042","article-title":"Rates and predictors of long-term seizure freedom after frontal lobe epilepsy surgery: a systematic review and meta-analysis","volume":"116","author":"Englot DJ","year":"2012","unstructured":"Englot DJ, Wang DD, Rolston JD, Shih TT, Chang EF. Rates and predictors of long-term seizure freedom after frontal lobe epilepsy surgery: a systematic review and meta-analysis. J Neurosurg. 2012;116(5):1042\u20131048."},{"issue":"5","key":"b9","series-title":"N Engl J Med","first-page":"311","article-title":"Efficiency of Surgery for Temporal Lobe Epilepsy Study Group. A randomized, controlled trial of surgery for temporal-lobe epilepsy","volume":"345","author":"Wiebe S","year":"2001","unstructured":"Wiebe S, Blume WT, Girvin JP, Eliasziw M; Effectiveness. Efficiency of Surgery for Temporal Lobe Epilepsy Study Group. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med. 2001;345(5):311\u2013318."},{"issue":"Pt 5","key":"b10","series-title":"Brain","first-page":"1188","article-title":"Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis","volume":"128","author":"T\u00e9llez-Zenteno JF","year":"2005","unstructured":"T\u00e9llez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain. 2005;128(Pt 5):1188\u20131198."},{"issue":"6","key":"b11","series-title":"J Neurosurg","first-page":"2071","article-title":"Predictors of seizure outcome following resective surgery for drug-resistant epilepsy associated with focal gliosis","volume":"130","author":"Dash GK","year":"2019","unstructured":"Dash GK, Rathore C, Jeyaraj MK, Wattamwar P, Sarma SP, Radhakrishnan K. Predictors of seizure outcome following resective surgery for drug-resistant epilepsy associated with focal gliosis. J Neurosurg. 2019;130(6):2071\u20132079."},{"issue":"5","key":"b12","series-title":"Neurosurg Rev","first-page":"1403","article-title":"Decision-making in temporal lobe epilepsy surgery based on invasive stereo-electroencephalography (sEEG)","volume":"43","author":"D\u00fchrsen L","year":"2020","unstructured":"D\u00fchrsen L, Sauvigny T, Ricklefs FL,  Decision-making in temporal lobe epilepsy surgery based on invasive stereo-electroencephalography (sEEG). Neurosurg Rev. 2020;43(5):1403\u20131408."},{"issue":"1","key":"b13","series-title":"Epilepsy Res","first-page":"75","article-title":"Predictors of epilepsy surgery outcome: a meta-analysis","volume":"62","author":"Tonini C","year":"2004","unstructured":"Tonini C, Beghi E, Berg AT,  Predictors of epilepsy surgery outcome: a meta-analysis. Epilepsy Res. 2004;62(1):75\u201387."},{"issue":"6","key":"b14","series-title":"Article in German. Internist (Berl)","first-page":"688","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting of observational studies","volume":"49","author":"von Elm E","year":"2008","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting of observational studies. Article in German. Internist (Berl). 2008;49(6):688\u2013693."},{"issue":"12","key":"b15","series-title":"Int J Surg","first-page":"1500","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration","volume":"12","author":"Vandenbroucke JP","year":"2014","unstructured":"Vandenbroucke JP, von Elm E, Altman DG,  Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Int J Surg. 2014;12(12):1500\u20131524."},{"issue":"2","key":"b16","series-title":"Epilepsia","first-page":"282","article-title":"ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery","volume":"42","author":"Wieser HG","year":"2001","unstructured":"Wieser HG, Blume WT, Fish D,  ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia. 2001;42(2):282\u2013286."},{"issue":"4","key":"b17","series-title":"Epilepsia","first-page":"512","article-title":"ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer IE","year":"2017","unstructured":"Scheffer IE, Berkovic S, Capovilla G,  ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512\u2013521."},{"issue":"9","key":"b18","series-title":"JAMA","first-page":"922","article-title":"Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial","volume":"307","author":"Engel J","year":"2012","unstructured":"Engel J, McDermott MP, Wiebe S,  Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA. 2012;307(9):922\u2013930."},{"issue":"2","key":"b19","series-title":"Neurosurg Clin N Am","first-page":"207","article-title":"Volume-outcome relationships in neurosurgery","volume":"26","author":"Davies JM","year":"2015","unstructured":"Davies JM, Ozpinar A, Lawton MT. Volume-outcome relationships in neurosurgery. Neurosurg Clin N Am. 2015;26(2):207\u2013218, viii."},{"issue":"1","key":"b20","series-title":"Br J Surg","first-page":"59","article-title":"Improving surgical outcomes through benchmarking","volume":"106","author":"Staiger RD","year":"2019","unstructured":"Staiger RD, Schwandt H, Puhan MA, Clavien PA. Improving surgical outcomes through benchmarking. Br J Surg. 2019;106(1):59\u201364."},{"issue":"7","key":"b21","series-title":"Acta Neurochir (Wien)","first-page":"1325","article-title":"Visual field deficits after epilepsy surgery: a new quantitative scoring method","volume":"160","author":"van Lanen RHGJ","year":"2018","unstructured":"van Lanen RHGJ, Hoeberigs MC, Bauer NJC,  Visual field deficits after epilepsy surgery: a new quantitative scoring method. Acta Neurochir (Wien). 2018;160(7):1325\u20131336."},{"key":"b22","series-title":"Seizure","first-page":"62","article-title":"Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: findings of the ROSE trial","volume":"63","author":"Quigg M","year":"2018","unstructured":"Quigg M, Barbaro NM, Ward MM,  Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: findings of the ROSE trial. Seizure. 2018;63:62\u201367."},{"issue":"3","key":"b23","series-title":"Brain","first-page":"1039","article-title":"Adolf Meyer: the neuroanatomist and neuropsychiatrist behind Meyer\u2019s loop and its significance in neurosurgery","volume":"143","author":"Schijns O","year":"2020","unstructured":"Schijns O, Koehler PJ. Adolf Meyer: the neuroanatomist and neuropsychiatrist behind Meyer\u2019s loop and its significance in neurosurgery. Brain. 2020;143(3):1039\u20131044."},{"issue":"8","key":"b24","series-title":"Epilepsia","first-page":"1273","article-title":"Prognostic factors for the surgery for mesial temporal lobe epilepsy: longitudinal analysis","volume":"46","author":"Jeong SW","year":"2005","unstructured":"Jeong SW, Lee SK, Hong KS, Kim KK, Chung CK, Kim H. Prognostic factors for the surgery for mesial temporal lobe epilepsy: longitudinal analysis. Epilepsia. 2005;46(8):1273\u20131279."},{"issue":"11","key":"b25","series-title":"Neurol Res","first-page":"884","article-title":"Operative variations in temporal lobe epilepsy surgery and seizure and memory outcome in 226 patients suffering from hippocampal sclerosis","volume":"43","author":"Roessler K","year":"2021","unstructured":"Roessler K, Kasper BS, Shawarba J,  Operative variations in temporal lobe epilepsy surgery and seizure and memory outcome in 226 patients suffering from hippocampal sclerosis. Neurol Res. 2021;43(11):884\u2013893."},{"key":"b26","series-title":"World Neurosurg","first-page":"531","article-title":"Risk of reoperation for hemorrhage in patients after craniotomy","volume":"87","author":"Algattas H","year":"2016","unstructured":"Algattas H, Kimmell KT, Vates GE. Risk of reoperation for hemorrhage in patients after craniotomy. World Neurosurg. 2016;87:531\u2013539."},{"issue":"3","key":"b27","series-title":"Epilepsy Behav","first-page":"402","article-title":"The effects of cognitive rehabilitation on memory outcome after temporal lobe epilepsy surgery","volume":"12","author":"Helmstaedter C","year":"2008","unstructured":"Helmstaedter C, Loer B, Wohlfahrt R,  The effects of cognitive rehabilitation on memory outcome after temporal lobe epilepsy surgery. Epilepsy Behav. 2008;12(3):402\u2013409."},{"issue":"31","key":"b1","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"821","article-title":"National and state estimates of the numbers of adults and children with active epilepsy -","volume":"66","author":"Zack MM","year":"2015","unstructured":"Zack MM, Kobau R. National and state estimates of the numbers of adults and children with active epilepsy -. United States,2015.MMWR Morb Mortal Wkly Rep. 2017;66(31):821\u2013825."},{"issue":"1","key":"b2","series-title":"Epilepsia","first-page":"37","article-title":"Early versus late remission in a cohort of patients with newly diagnosed epilepsy","volume":"51","author":"Del Felice A","year":"2010","unstructured":"Del Felice A, Beghi E, Boero G,  Early versus late remission in a cohort of patients with newly diagnosed epilepsy. Epilepsia. 2010;51(1):37\u201342."},{"issue":"4","key":"b3","series-title":"Lancet Neurol","first-page":"344","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"23","year":"2024","unstructured":"Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024;23(4):344\u2013381."},{"issue":"5","key":"b4","series-title":"Neurosurgery","first-page":"676","article-title":"Seizure outcome of temporal lobe epilepsy surgery in adults and children: a systematic review and meta-analysis","volume":"91","author":"Barba C","year":"2022","unstructured":"Barba C, Giometto S, Lucenteforte E,  Seizure outcome of temporal lobe epilepsy surgery in adults and children: a systematic review and meta-analysis. Neurosurgery. 2022;91(5):676\u2013683."},{"issue":"Suppl 1","key":"b5","series-title":"Epilepsia.","first-page":"10","article-title":"Microsurgical techniques in temporal lobe epilepsy","volume":"58","author":"Alonso Vanegas MA","year":"2017","unstructured":"Alonso Vanegas MA, Lew SM, Morino M, Sarmento SA. Microsurgical techniques in temporal lobe epilepsy. Epilepsia. 2017;58 Suppl 1:10\u201318."},{"issue":"3","key":"b6","series-title":"JAMA","first-page":"285","article-title":"Resective epilepsy surgery for drug-resistant focal epilepsy: a review","volume":"313","author":"Jobst BC","year":"2015","unstructured":"Jobst BC, Cascino GD. Resective epilepsy surgery for drug-resistant focal epilepsy: a review. JAMA. 2015;313(3):285\u2013293."},{"key":"b7","series-title":"World Neurosurg","first-page":"639","article-title":"Complications after surgery for mesial temporal lobe epilepsy associated with hippocampal sclerosis","volume":"102","author":"Mathon B","year":"2017","unstructured":"Mathon B, Navarro V, Bielle F,  Complications after surgery for mesial temporal lobe epilepsy associated with hippocampal sclerosis. World Neurosurg. 2017;102:639\u2013650e2."},{"issue":"5","key":"b8","series-title":"J Neurosurg","first-page":"1042","article-title":"Rates and predictors of long-term seizure freedom after frontal lobe epilepsy surgery: a systematic review and meta-analysis","volume":"116","author":"Englot DJ","year":"2012","unstructured":"Englot DJ, Wang DD, Rolston JD, Shih TT, Chang EF. Rates and predictors of long-term seizure freedom after frontal lobe epilepsy surgery: a systematic review and meta-analysis. J Neurosurg. 2012;116(5):1042\u20131048."},{"issue":"5","key":"b9","series-title":"N Engl J Med","first-page":"311","article-title":"Efficiency of Surgery for Temporal Lobe Epilepsy Study Group. A randomized, controlled trial of surgery for temporal-lobe epilepsy","volume":"345","author":"Wiebe S","year":"2001","unstructured":"Wiebe S, Blume WT, Girvin JP, Eliasziw M; Effectiveness. Efficiency of Surgery for Temporal Lobe Epilepsy Study Group. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med. 2001;345(5):311\u2013318."},{"issue":"Pt 5","key":"b10","series-title":"Brain","first-page":"1188","article-title":"Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis","volume":"128","author":"T\u00e9llez-Zenteno JF","year":"2005","unstructured":"T\u00e9llez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain. 2005;128(Pt 5):1188\u20131198."},{"issue":"6","key":"b11","series-title":"J Neurosurg","first-page":"2071","article-title":"Predictors of seizure outcome following resective surgery for drug-resistant epilepsy associated with focal gliosis","volume":"130","author":"Dash GK","year":"2019","unstructured":"Dash GK, Rathore C, Jeyaraj MK, Wattamwar P, Sarma SP, Radhakrishnan K. Predictors of seizure outcome following resective surgery for drug-resistant epilepsy associated with focal gliosis. J Neurosurg. 2019;130(6):2071\u20132079."},{"issue":"5","key":"b12","series-title":"Neurosurg Rev","first-page":"1403","article-title":"Decision-making in temporal lobe epilepsy surgery based on invasive stereo-electroencephalography (sEEG)","volume":"43","author":"D\u00fchrsen L","year":"2020","unstructured":"D\u00fchrsen L, Sauvigny T, Ricklefs FL,  Decision-making in temporal lobe epilepsy surgery based on invasive stereo-electroencephalography (sEEG). Neurosurg Rev. 2020;43(5):1403\u20131408."},{"issue":"1","key":"b13","series-title":"Epilepsy Res","first-page":"75","article-title":"Predictors of epilepsy surgery outcome: a meta-analysis","volume":"62","author":"Tonini C","year":"2004","unstructured":"Tonini C, Beghi E, Berg AT,  Predictors of epilepsy surgery outcome: a meta-analysis. Epilepsy Res. 2004;62(1):75\u201387."},{"issue":"6","key":"b14","series-title":"Article in German. Internist (Berl)","first-page":"688","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting of observational studies","volume":"49","author":"von Elm E","year":"2008","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting of observational studies. Article in German. Internist (Berl). 2008;49(6):688\u2013693."},{"issue":"12","key":"b15","series-title":"Int J Surg","first-page":"1500","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration","volume":"12","author":"Vandenbroucke JP","year":"2014","unstructured":"Vandenbroucke JP, von Elm E, Altman DG,  Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Int J Surg. 2014;12(12):1500\u20131524."},{"issue":"2","key":"b16","series-title":"Epilepsia","first-page":"282","article-title":"ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery","volume":"42","author":"Wieser HG","year":"2001","unstructured":"Wieser HG, Blume WT, Fish D,  ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia. 2001;42(2):282\u2013286."},{"issue":"4","key":"b17","series-title":"Epilepsia","first-page":"512","article-title":"ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer IE","year":"2017","unstructured":"Scheffer IE, Berkovic S, Capovilla G,  ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512\u2013521."},{"issue":"9","key":"b18","series-title":"JAMA","first-page":"922","article-title":"Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial","volume":"307","author":"Engel J","year":"2012","unstructured":"Engel J, McDermott MP, Wiebe S,  Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA. 2012;307(9):922\u2013930."},{"issue":"2","key":"b19","series-title":"Neurosurg Clin N Am","first-page":"207","article-title":"Volume-outcome relationships in neurosurgery","volume":"26","author":"Davies JM","year":"2015","unstructured":"Davies JM, Ozpinar A, Lawton MT. Volume-outcome relationships in neurosurgery. Neurosurg Clin N Am. 2015;26(2):207\u2013218, viii."},{"issue":"1","key":"b20","series-title":"Br J Surg","first-page":"59","article-title":"Improving surgical outcomes through benchmarking","volume":"106","author":"Staiger RD","year":"2019","unstructured":"Staiger RD, Schwandt H, Puhan MA, Clavien PA. Improving surgical outcomes through benchmarking. Br J Surg. 2019;106(1):59\u201364."},{"issue":"7","key":"b21","series-title":"Acta Neurochir (Wien)","first-page":"1325","article-title":"Visual field deficits after epilepsy surgery: a new quantitative scoring method","volume":"160","author":"van Lanen RHGJ","year":"2018","unstructured":"van Lanen RHGJ, Hoeberigs MC, Bauer NJC,  Visual field deficits after epilepsy surgery: a new quantitative scoring method. Acta Neurochir (Wien). 2018;160(7):1325\u20131336."},{"key":"b22","series-title":"Seizure","first-page":"62","article-title":"Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: findings of the ROSE trial","volume":"63","author":"Quigg M","year":"2018","unstructured":"Quigg M, Barbaro NM, Ward MM,  Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: findings of the ROSE trial. Seizure. 2018;63:62\u201367."},{"issue":"3","key":"b23","series-title":"Brain","first-page":"1039","article-title":"Adolf Meyer: the neuroanatomist and neuropsychiatrist behind Meyer\u2019s loop and its significance in neurosurgery","volume":"143","author":"Schijns O","year":"2020","unstructured":"Schijns O, Koehler PJ. Adolf Meyer: the neuroanatomist and neuropsychiatrist behind Meyer\u2019s loop and its significance in neurosurgery. Brain. 2020;143(3):1039\u20131044."},{"issue":"8","key":"b24","series-title":"Epilepsia","first-page":"1273","article-title":"Prognostic factors for the surgery for mesial temporal lobe epilepsy: longitudinal analysis","volume":"46","author":"Jeong SW","year":"2005","unstructured":"Jeong SW, Lee SK, Hong KS, Kim KK, Chung CK, Kim H. Prognostic factors for the surgery for mesial temporal lobe epilepsy: longitudinal analysis. Epilepsia. 2005;46(8):1273\u20131279."},{"issue":"11","key":"b25","series-title":"Neurol Res","first-page":"884","article-title":"Operative variations in temporal lobe epilepsy surgery and seizure and memory outcome in 226 patients suffering from hippocampal sclerosis","volume":"43","author":"Roessler K","year":"2021","unstructured":"Roessler K, Kasper BS, Shawarba J,  Operative variations in temporal lobe epilepsy surgery and seizure and memory outcome in 226 patients suffering from hippocampal sclerosis. Neurol Res. 2021;43(11):884\u2013893."},{"key":"b26","series-title":"World Neurosurg","first-page":"531","article-title":"Risk of reoperation for hemorrhage in patients after craniotomy","volume":"87","author":"Algattas H","year":"2016","unstructured":"Algattas H, Kimmell KT, Vates GE. Risk of reoperation for hemorrhage in patients after craniotomy. World Neurosurg. 2016;87:531\u2013539."},{"issue":"3","key":"b27","series-title":"Epilepsy Behav","first-page":"402","article-title":"The effects of cognitive rehabilitation on memory outcome after temporal lobe epilepsy surgery","volume":"12","author":"Helmstaedter C","year":"2008","unstructured":"Helmstaedter C, Loer B, Wohlfahrt R,  The effects of cognitive rehabilitation on memory outcome after temporal lobe epilepsy surgery. Epilepsy Behav. 2008;12(3):402\u2013409."}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/144\/6\/article-p1359.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/144\/6\/article-p1359.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/144\/6\/article-p1359.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:32:55Z","timestamp":1781793175000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/144\/6\/article-p1359.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":54,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2025.8.jns243031","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]}}}