{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:04:26Z","timestamp":1782864266762,"version":"3.54.5"},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>The Management of Myelomeningocele Study (MOMS) established that prenatal repair of myelomeningocele (MMC) improved the rate of ventriculoperitoneal shunt insertion for the treatment of hydrocephalus, compared to postnatal repair. While there was mild improvement of motor function, most children were unable to ambulate independently. Therefore, the ongoing phase 1\/2a clinical trial Cellular Therapy for In Utero Repair of Myelomeningocele (CuRe trial) aims to further improve distal neurological function using placenta-derived mesenchymal stem\/stromal cells seeded on an extracellular matrix (PMSC-ECM) to augment open fetal repair of MMC. Here, the authors present a video of the neurosurgical repair using the PMSC-ECM.<\/jats:p>\n                  <jats:p>\n                    The video can be found here:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/stream.cadmore.media\/r10.3171\/2026.1.FOCVID25229\">https:\/\/stream.cadmore.media\/r10.3171\/2026.1.FOCVID25229<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.3171\/2026.1.focvid25229","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:27:34Z","timestamp":1775010454000},"page":"V11","source":"Crossref","is-referenced-by-count":0,"title":["Cellular Therapy for In Utero Repair of Myelomeningocele (the CuRe trial): neurosurgical repair video"],"prefix":"10.3171","volume":"14","author":[{"given":"Elizabeth","family":"Reynolds","sequence":"first","affiliation":[{"name":"Department of Surgery,"},{"name":"Center for Bioengineering in Medicine, University of California, Davis Health, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Saadai","sequence":"additional","affiliation":[{"name":"Department of Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Sadegh","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia S.","family":"McLennan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin G.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie E.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadarsini","family":"Kumar","sequence":"additional","affiliation":[{"name":"Center for Bioengineering in Medicine, University of California, Davis Health, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Bioengineering in Medicine, University of California, Davis Health, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center for Bioengineering in Medicine, University of California, Davis Health, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marike","family":"Zwienenberg","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"11","key":"b1","series-title":"N Engl J Med","first-page":"993","article-title":"A randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"Adzick NS","year":"2011","unstructured":"Adzick NS, Thom EA, Spong CY,  A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med. 2011;364(11):993\u20131004. doi:10.1056\/NEJMoa1014379"},{"issue":"2","key":"b2","series-title":"Am J Obstet Gynecol","first-page":"256.e1","article-title":"The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes","volume":"218","author":"Farmer DL","year":"2018","unstructured":"Farmer DL, Thom EA, Brock JW,  The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. Am J Obstet Gynecol. 2018;218(2):256.e1\u2013256.e13. doi:10.1016\/j.ajog.2017.12.001"},{"key":"b3","article-title":"Cellular Therapy for In Utero Repair of Myelomeningocele\u2014The CuRe Trial","unstructured":"Cellular Therapy for In Utero Repair of Myelomeningocele\u2014The CuRe Trial. NCT04652908. ClinicalTrials.gov. Registered June 21, 2021. Accessed October 1, 2025. https:\/\/clinicaltrials.gov\/study\/NCT04652908"},{"issue":"6","key":"b4","series-title":"Stem Cells Transl Med","first-page":"659","article-title":"Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele","volume":"4","author":"Wang A","year":"2015","unstructured":"Wang A, Brown EG, Lankford L,  Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele. Stem Cells Transl Med. 2015;4(6):659\u2013669. doi:10.5966\/sctm.2014-0296"},{"issue":"5","key":"b5","series-title":"FASEB J","first-page":"5836","article-title":"Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes","volume":"33","author":"Kumar P","year":"2019","unstructured":"Kumar P, Becker JC, Gao K,  Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes. FASEB J. 2019;33(5):5836\u20135849. doi:10.1096\/fj.201800972R"},{"key":"b6","series-title":"J Pediatr Surg","first-page":"S0022","article-title":"Placental mesenchymal stromal cells seeded on clinical grade extracellular matrix improve ambulation in ovine myelomeningocele","author":"Kabagambe S","year":"2017","unstructured":"Kabagambe S, Keller B, Becker J,  Placental mesenchymal stromal cells seeded on clinical grade extracellular matrix improve ambulation in ovine myelomeningocele. J Pediatr Surg. 2017:S0022. doi:10.1016\/j.jpedsurg.2017.10.032"},{"issue":"11","key":"b1","series-title":"N Engl J Med","first-page":"993","article-title":"A randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"Adzick NS","year":"2011","unstructured":"Adzick NS, Thom EA, Spong CY,  A randomized trial of prenatal versus postnatal repair of myelomeningocele. 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