{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T10:25:29Z","timestamp":1794219929374,"version":"4.8.0"},"reference-count":23,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The aim of the present study was to review the surgical outcomes of endoscopic skull base surgery (ESBS) for the treatment of skull base chordoma (SBC) at the authors\u2019 institution over the past 2 decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The electronic medical records of patients who underwent resection of primary SBC at the University of Pittsburgh Medical Center from 2001 to 2020 were retrospectively reviewed. Patients were split into two groups: primary or recurrent tumor. The primary outcome in this analysis was extent of resection. Secondary outcomes included progression-free survival (PFS) and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>This analysis included 194 individual patients on whom 269 total resections were performed. Within the authors\u2019 sample, 95 resections were for primary tumors and 174 resections were for recurrent tumors. The mean PFS among tumor patients who received gross-total resection (GTR) was 103.5 months, near-total resection (NTR) was 27.1 months, and subtotal resection (STR) was 12.2 months. Not accounting for adjuvant radiation, GTR allowed for significantly longer PFS than NTR (p &lt; 0.001) or STR (p &lt; 0.001). For tumors that did not receive adjuvant radiation, GTR allowed for significantly longer PFS than non-GTR (p = 0.013). The factors that were associated with GTR were prior radiation (OR 0.302) and institutional experience (OR 1.225). The percentage of GTRs among all tumors in our sample increased significantly and incrementally from 2001 to 2020 (7.7% to 78%, p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>GTR is an important factor influencing PFS in patients with SBC. Experience with ESBS has a significant effect on outcomes. GTR rates (especially for recurrent tumors) and incidence of complications have improved at the authors\u2019 institution, which may be correlated to institutional experience.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2026.1.jns251263","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:14:58Z","timestamp":1782864898000},"page":"1117-1127","source":"Crossref","is-referenced-by-count":0,"title":["An institutional review of clinical outcomes for skull base chordoma: an analysis of 269 cases over 19 years"],"prefix":"10.3171","volume":"145","author":[{"given":"Nallammai","family":"Muthiah","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary C.","family":"Gersey","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania;"},{"name":"Department of Neurological Surgery, Loma Linda University Medical Center, Loma Linda, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Fernandes Cabral","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam","family":"Abou-Al-Shaar","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garret","family":"Choby","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios A.","family":"Zenonos","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurol Med Chir (Tokyo)","first-page":"PS1","article-title":"Report of Brain Tumor Registry of Japan (1984-2000)","volume":"49 Suppl","year":"2009","unstructured":"Report of Brain Tumor Registry of Japan (1984-2000).Neurol Med Chir (Tokyo). 2009;49 Suppl:PS1\u201396."},{"issue":"1","key":"b2","series-title":"Cancer Causes Control","first-page":"1","article-title":"Chordoma: incidence and survival patterns in the United States, 1973-1995","volume":"12","author":"McMaster ML","year":"2001","unstructured":"McMaster ML, Goldstein AM, Bromley CM, Ishibe N, Parry DM. 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