{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T10:25:27Z","timestamp":1794219927408,"version":"4.8.0"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Radiofrequency thermocoagulation (RFT) of the gasserian ganglion provides rapid pain relief in trigeminal neuralgia (TN) and is minimally invasive. In multiple sclerosis (MS)\u2013associated TN (MS-TN), recurrence may be more frequent than in idiopathic\/classic TN (Id-TN), possibly due to demyelinating pathology. This study compared RFT outcomes between these etiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors conducted a STROBE-compliant, single-center retrospective cohort study that screened 636 patients with TN treated between March 2012 and September 2021. Structured telephone interviews were completed in 350 patients, including the 5-level EQ-5D (EQ-5D-5L) for health-related quality of life (HRQOL). Of these patients, 182 received RFT as their first invasive treatment. The primary endpoint was the pain-free interval (PFI), defined as the time to recurrence (Barrow Neurological Institute Pain Intensity Scale score \u2265 II or medication restart), analyzed using Kaplan-Meier curves and Cox proportional hazards regression models. Secondary outcomes included repeat interventions, permanent sensory deficits, and HRQOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of 182 eligible participants, 77 had MS-TN and 105 had Id-TN. Patients with MS-TN were younger (mean age 55.8 [SD 10.6] vs 70.5 [SD 8.6] years, p &lt; 0.001). The median PFI was 33.9 (95% CI 15.5\u201352.3) months for MS-TN versus 87.0 (95% CI 43.1\u2013130.9) months for Id-TN (p = 0.0493, log-rank test). The mean overall follow-up duration was 68.4 months. Despite earlier recurrence, repeat interventions achieved comparable adequate pain control at the last follow-up (68.8% in MS-TN vs 77.1% in Id-TN, p = 0.139). EQ-5D-5L scores improved significantly and converged at follow-up (p = 0.085).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>After the first RFT, pain control was shorter in MS-TN than in Id-TN. However, retreatment effectively restored long-term pain control and HRQOL, supporting the role of RFT in managing MS-TN. Regular follow-up is recommended to facilitate timely intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2026.1.jns251957","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:39Z","timestamp":1780444839000},"page":"1215-1222","source":"Crossref","is-referenced-by-count":0,"title":["Repeat radiofrequency thermocoagulation for multiple sclerosis\u2013associated versus idiopathic trigeminal neuralgia: a comparison of long-term pain control"],"prefix":"10.3171","volume":"145","author":[{"given":"Tobias","family":"Greve","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital, LMU Munich;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattis","family":"Kuklinski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital, LMU Munich;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Ringel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital, LMU Munich;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Muacevic","sequence":"additional","affiliation":[{"name":"European Radiosurgery Center Munich, Bavaria, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Hinnerk","family":"Mehrkens","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital, LMU Munich;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Br J Anaesth","first-page":"117","article-title":"Trigeminal neuralgia\u2013pathophysiology, diagnosis and current treatment","volume":"87","author":"Nurmikko TJ","year":"2001","unstructured":"Nurmikko TJ, Eldridge PR. 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