{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:00:40Z","timestamp":1790388040393,"version":"4.1.0"},"reference-count":37,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Intracranial aneurysm (IA) is a leading cause of subarachnoid hemorrhage, characterized by complex pathogenesis and high mortality rates due to rupture. The aim of this study was to develop a targeted glucagon-like peptide-1 (GLP-1) nanodelivery system to mobilize endothelial progenitor cells (EPCs) and enhance re-endothelialization in a rat model of coiled IA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this study, a matrix metalloproteinase-2 (MMP-2)\u2013targeted nanodelivery platform (hereafter GLP-1@tMSN [targeted mesoporous silica nanoparticle]) based on MSNs functionalized with GLP-1 was developed to mobilize EPCs and accelerate vascular repair. The efficacy of GLP-1@tMSN in promoting EPC recruitment and re-endothelialization was evaluated in a rat coiled aneurysm model, alongside mechanistic studies of the Wnt\/\u03b2-catenin signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In a rat model of coiled IA, GLP-1@tMSN significantly enhanced the recruitment of EPCs and promoted re-endothelialization. Histological analysis demonstrated the formation of mature endothelial-like tissue after 28 days, in contrast to the fibrous tissue observed in the control group. Immunofluorescence analysis confirmed the preferential accumulation of CD34\n                      <jats:sup>+<\/jats:sup>\n                      VEGFR2\n                      <jats:sup>+<\/jats:sup>\n                      EPCs at the lesion site, with concurrent activation of the Wnt\/\u03b2-catenin pathway, implicating its pivotal role in driving vascular repair. Preliminary safety evaluations further indicated a favorable biocompatibility profile for the nanotherapeutic system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The developed functionalized nanodelivery platform represents a promising therapeutic strategy to enhance localized GLP-1 efficacy, facilitating rapid re-endothelialization and potentially reducing long-term recurrence of IAs after embolization. This approach shows substantial potential for improving outcomes for patients with IA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2026.1.jns252263","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:44Z","timestamp":1781049644000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Targeted GLP-1 nanotherapy for Wnt\/\u03b2-catenin activation to enhance endothelial progenitor cell\u2013mediated re-endothelialization and prevent intracranial aneurysm recurrence"],"prefix":"10.3171","author":[{"given":"Guo","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai;"},{"name":"National Center for Neurological Disorders, Shanghai;"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai;"},{"name":"Neurosurgical Institute of Fudan University, Shanghai;"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuxun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai;"},{"name":"National Center for Neurological Disorders, Shanghai;"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai;"},{"name":"Neurosurgical Institute of Fudan University, Shanghai;"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonglin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai;"},{"name":"National Center for Neurological Disorders, Shanghai;"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai;"},{"name":"Neurosurgical Institute of Fudan University, Shanghai;"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganglei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai;"},{"name":"National Center for Neurological Disorders, Shanghai;"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai;"},{"name":"Neurosurgical Institute of Fudan University, Shanghai;"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Huashan Hospital, Fudan University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai;"},{"name":"National Center for Neurological Disorders, Shanghai;"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai;"},{"name":"Neurosurgical Institute of Fudan University, Shanghai;"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai;"},{"name":"National Center for Neurological Disorders, Shanghai;"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai;"},{"name":"Neurosurgical Institute of Fudan University, Shanghai;"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"N Engl J Med","first-page":"28","article-title":"Intracranial aneurysms.","volume":"336","author":"Schievink WI","year":"1997","unstructured":"Schievink WI. 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