{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:21:14Z","timestamp":1794327674381,"version":"4.9.0"},"reference-count":29,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,29]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Posthemorrhagic ventricular dilation (PHVD) is a serious complication of intraventricular hemorrhage in extremely preterm infants, associated with high rates of death and neurodevelopmental impairment. Earlier CSF diversion might reduce adverse outcomes, but variability in practice persists. In 2021, a tertiary care center implemented a standardized multidisciplinary PHVD treatment pathway that emphasized standardized ventricular measurements and earlier thresholds for intervention. The aim of this study was to evaluate whether this treatment pathway reduced ventricular dilation and improved developmental outcomes in neonates with PHVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This single-center cohort study analyzed outcomes of neonates born between 2017 and 2023 who underwent PHVD intervention. Patients were dichotomized according to whether they were born before the treatment pathway was implemented (pre-pathway group) or after (post-pathway group). Data were extracted from the Hydrocephalus Clinical Research Network prospective registry and clinical records. Interventions included lumbar puncture (LP), ventricular reservoir placement, and ventriculoperitoneal shunt (VPS) placement. Ventricular dilation was measured using the anterior horn width (AHW) and ventricular index (VI). Developmental outcomes were assessed at \u2265 18 months using standardized development assessments and neurological evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Overall, 104 patients were included; 59 in the pre-pathway group and 45 in the post-pathway group (10 of whom underwent only LP and were included only in an LP subset analysis). Following pathway implementation, high-volume LP was completed in 93% of patients. The median maximum AHW and VI greater than 2 standard deviations above the mean were significantly lower in the post-pathway group (AHW: 32 mm vs 26 mm, p = 0.03; VI: 18 vs 15 mm &gt; 2 standard deviations, p = 0.04). Among 74 infants with 18 months of follow-up, the primary outcome of death or severe cerebral palsy was reduced by 29% after pathway implementation (62% pre-pathway vs 33% post-pathway, p = 0.03). The multivariable analysis of all neonates demonstrated that larger ventricular size at VPS placement and at maximum ventricular dilation independently predicted higher odds of death or severe cerebral palsy, with a 9% increase per 1-mm increase in maximum AHW (adjusted OR 1.09, 95% CI 1.03\u20131.16, p = 0.006) and 14% increase per 1-mm increase in pre-VPS AHW (adjusted OR 1.14, 95% CI 1.05\u20131.24, p = 0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This study found potential for improved neurodevelopmental outcomes with pragmatic implementation of a collaborative standardized pathway for PHVD care. Pathway implementation was associated with reduced ventricular size at VPS placement, and smaller maximum ventricular size was a strong independent predictor of improved neurodevelopmental outcomes. These findings support earlier standardized PHVD intervention and highlight the need for larger multicenter studies to validate standardized and pragmatic early intervention approaches for PHVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2026.1.peds25574","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:01:01Z","timestamp":1779840061000},"page":"153-163","source":"Crossref","is-referenced-by-count":0,"title":["Implementing early posthemorrhagic ventricular dilation intervention in preterm neonates: does a standardized pathway improve outcomes?"],"prefix":"10.3171","volume":"38","author":[{"given":"Jennifer C.","family":"Keene","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Child Neurology, University of Utah, Salt Lake City;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Ostrander","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Child Neurology, University of Utah, Salt Lake City;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Child Neurology, University of Utah, Salt Lake City;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Franklin Carbaugh","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Intermountain Healthcare, Salt Lake City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R. 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