{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:59:48Z","timestamp":1790391588167,"version":"4.1.0"},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Posthemorrhagic hydrocephalus (PHH) is a significant complication of intraventricular hemorrhage (IVH) in preterm neonates. Neuroendoscopic lavage (NEL) is a treatment option. The authors aimed to evaluate the effectiveness and safety of NEL alone for early treatment of PHH in neonates.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n This systematic review and meta-analysis were conducted according to Cochrane Collaboration guidelines and the PRISMA statement. A comprehensive search of databases (PubMed, Embase, Google Scholar, and Web of Science) was conducted to identify studies evaluating NEL in the treatment of PHH in neonates. The analysis used random-effects models. The primary outcome was dependency on a ventriculoperitoneal (VP) shunt. Secondary outcomes included infection rates, multiloculated hydrocephalus, and mortality.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n The authors evaluated 312 neonates from 9 studies. The pooled analysis revealed a shunt dependency rate of 58.3% (95% CI 52.5\u201364.2%, I\n 2<\/jats:sup>\n = 10%). The infection rate was 5.6% (95% CI 1.7\u20139.6%, I\n 2<\/jats:sup>\n = 48.4%), while the incidence of multiloculated hydrocephalus was 6.5% (95% CI 1.56\u201311.4%, I\n 2<\/jats:sup>\n = 32.6%). Mortality was low at 2.4% (95% CI 0%\u20134.9%, I\n 2<\/jats:sup>\n = 25.2%).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n This meta-analysis of NEL for neonatal PHH showed moderate rates of shunt dependence, along with low rates of infection and mortality. These findings suggest that NEL is a safe procedure associated with relatively low VP shunt dependence; however, well-designed randomized controlled trials are required to confirm these results and to compare NEL with traditional management strategies.<\/jats:p>\n \n Systematic review registration no.: CRD42024556947 (\n https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>\n )\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2026.3.peds25406","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:01:42Z","timestamp":1785283302000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Neuroendoscopic lavage in neonatal posthemorrhagic hydrocephalus: a systematic review and single-arm meta-analysis"],"prefix":"10.3171","author":[{"given":"Walter","family":"Fagundes","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucca T. A.","family":"Carretta","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Medicine, Escola Superior de Ci\u00eancias da Santa Casa de Miseric\u00f3rdia de Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Kotochinsky","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Medicine, National University of Cuyo, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael R. D.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Medicine, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iago N. S.","family":"Petry","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Medicine, University of Southern Santa Catarina, Florianopolis, Santa Catarina, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Internal Medicine, Healthcare Institution of South Iceland, Selfoss, \u00c1rborg, Iceland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"\u0141ajczak","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Medicine, Medical University of Silesia, Poland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo F. O.","family":"Suruagy-Motta","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Medicine, Cesmac University Center, Macei\u00f3, Alagoas, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz G. S.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Medicine, Catholic University of Bras\u00edlia, Distrito Federal, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael T. F.","family":"Santos","sequence":"additional","affiliation":[{"name":"Geneuro - International Research Group in Neuroscience, Vit\u00f3ria, Esp\u00edrito Santo, Brazil;"},{"name":"Department of Medicine, Medical Education Institute Vista Carioca, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"10020","key":"b1","series-title":"Lancet","first-page":"788","article-title":"Hydrocephalus in children","volume":"387","author":"Kahle KT","year":"2016","unstructured":"Kahle KT, Kulkarni AV, Limbrick DD Jr, Warf BC. Hydrocephalus in children. 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