{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T10:25:32Z","timestamp":1794219932036,"version":"4.8.0"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>Eug\u00e8ne-Louis Doyen studied medicine in Reims and Paris, further refining his surgical approach through experiences in Heidelberg, W\u00fcrzburg, and Vienna. Recognized in French surgery for his innovations across thoracic, abdominal, and gynecological disciplines, his critical contributions to early neurosurgery, particularly trigeminal neuralgia treatment, remain significantly underexplored. Combining elements from the Hartley-Krause subtemporal route and the Rose sphenoidal route, he developed an advanced trigeminal ganglionectomy technique to minimize complications. Doyen introduced the electric craniotome, instruments specifically designed for dural detachment, and specialized devices to enable precise en bloc ganglion removal, thereby enhancing surgical safety and efficiency. He developed a minimally invasive retrosigmoid craniotomy approach using a speculum and custom neurotome to sever the sensory trigeminal root. This groundbreaking cerebellopontine angle endoscopy technique substantially reduced invasiveness compared to more extensive gasserectomy procedures. Despite the considerable controversy stemming from his abrasive personality, unorthodox methods, and provocative practices, such as filming surgical procedures, Doyen\u2019s bold innovations advanced neurosurgical techniques at the turn of the 20th century. Examining his career offers essential insights into a pivotal transitional era when ambitious operations on the brain began evolving into more precise, organized, and effective neurosurgical practices.<\/jats:p>","DOI":"10.3171\/2026.4.jns252504","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:01:17Z","timestamp":1787702477000},"page":"1542-1552","source":"Crossref","is-referenced-by-count":0,"title":["A surgeon beyond his era: neurosurgical contributions of Eug\u00e8ne-Louis Doyen (1859\u20131916)"],"prefix":"10.3171","volume":"145","author":[{"given":"Ali","family":"Tayebi Meybodi","sequence":"first","affiliation":[{"name":"The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, Arizona; and"},{"name":"Rutgers New Jersey Medical School, Department of Neurosurgery, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"On","sequence":"additional","affiliation":[{"name":"The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre A.","family":"Payman","sequence":"additional","affiliation":[{"name":"Rutgers New Jersey Medical School, Department of Neurosurgery, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Calderon Valero","sequence":"additional","affiliation":[{"name":"The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Alcantar-Garibay","sequence":"additional","affiliation":[{"name":"The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooneh","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Rutgers New Jersey Medical School, Department of Neurosurgery, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Castillo","sequence":"additional","affiliation":[{"name":"The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kivanc","family":"Yangi","sequence":"additional","affiliation":[{"name":"The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Preul","sequence":"additional","affiliation":[{"name":"The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Surgical Therapeutics and Operative Technique","first-page":"1","author":"Doyen EL","year":"1917","unstructured":"Doyen EL, Spencer-Browne H. Surgical Therapeutics and Operative Technique. Macmillan;1917;1."},{"issue":"2","key":"b2","series-title":"J Neurosurg","first-page":"573","article-title":"The temporary resection of the cranial vault by Wilhelm Wagner (1848-1900) instead of trepanation: the cornerstone of the modern craniotomy","volume":"139","author":"Gonz\u00e1lez-Darder JM","year":"2023","unstructured":"Gonz\u00e1lez-Darder JM, Capilla-Guasch P. The temporary resection of the cranial vault by Wilhelm Wagner (1848-1900) instead of trepanation: the cornerstone of the modern craniotomy. J Neurosurg. 2023;139(2):573\u2013578. doi:10.3171\/2022.11.JNS221680"},{"issue":"2","key":"b3","series-title":"J Neurosurg","first-page":"534","article-title":"Sir Victor Horsley\u2019s 19th century operations at the National Hospital for Neurology and Neurosurgery, Queen Square","volume":"114","author":"Uff C","year":"2011","unstructured":"Uff C, Frith D, Harrison C, Powell M, Kitchen N. Sir Victor Horsley\u2019s 19th century operations at the National Hospital for Neurology and Neurosurgery, Queen Square. J Neurosurg. 2011;114(2):534\u2013542. doi:10.3171\/2010.9.JNS09731"},{"issue":"1","key":"b4","series-title":"J Neurosurg","first-page":"133","article-title":"William Macewen and the treatment of brain abscesses: revisited after one hundred years","volume":"84","author":"Canale DJ","year":"1996","unstructured":"Canale DJ. William Macewen and the treatment of brain abscesses: revisited after one hundred years. J Neurosurg. 1996;84(1):133\u2013142. doi:10.3171\/jns.1996.84.1.0133"},{"key":"b5","series-title":"Trait\u00e9 de th\u00e9rapeutique chirurgicale et de technique op\u00e9ratoire","author":"Doyen EL","year":"1912","unstructured":"Doyen EL. Trait\u00e9 de th\u00e9rapeutique chirurgicale et de technique op\u00e9ratoire. Maloine; 1912."},{"issue":"6","key":"b6","series-title":"Surg Innov","first-page":"645","article-title":"Eugene Louis Doyen (1859-1916): the reformer of French surgery","volume":"25","author":"Laios K","year":"2018","unstructured":"Laios K, Charalampakis A, Manes K, Lagiou E, Mavrommatis E, Karamanou M. Eugene Louis Doyen (1859-1916): the reformer of French surgery. Surg Innov. 2018;25(6):645\u2013647. doi:10.1177\/1553350618799541"},{"key":"b7","series-title":"Eug\u00e8ne-Louis Doyen: chirurgien g\u00e9nial et scandaleux de la Belle \u00c9poque","author":"Scherpereel P","year":"2018","unstructured":"Scherpereel P. Eug\u00e8ne-Louis Doyen: chirurgien g\u00e9nial et scandaleux de la Belle \u00c9poque. Editions L\u2019Harmattan; 2018."},{"key":"b8","series-title":"Maisonneuve","author":"Doyen EL","year":"1897","unstructured":"Doyen EL. Maisonneuve. Institut international de bibliographie scientifique; 1897."},{"key":"b9","series-title":"Recherches anatomiques et exp\u00e9rimentales sur le chol\u00e9ra \u00e9pid\u00e9mique","author":"Doyen EL","year":"1885","unstructured":"Doyen EL. Recherches anatomiques et exp\u00e9rimentales sur le chol\u00e9ra \u00e9pid\u00e9mique. Biblioth\u00e8que interuniversitaire de sant\u00e9; 1885."},{"key":"b10","series-title":"Technique chirurgicale","author":"Doyen EL","year":"1897","unstructured":"Doyen EL. Technique chirurgicale. Masson; 1897."},{"key":"b11","series-title":"World Neurosurg","first-page":"260","article-title":"Contributions of Laurent Princeteau to trigeminal neuralgia and middle fossa anatomy: more than a mere tubercle","volume":"190","author":"Tayebi Meybodi A","year":"2024","unstructured":"Tayebi Meybodi A, Gomez-Castro G, Dagi TF, Preul MC. Contributions of Laurent Princeteau to trigeminal neuralgia and middle fossa anatomy: more than a mere tubercle. World Neurosurg. 2024;190:260\u2013274. doi:10.1016\/j.wneu.2024.07.045"},{"key":"b12","series-title":"Le malade et le m\u00e9decin","author":"Doyen EL","year":"1906","unstructured":"Doyen EL. Le malade et le m\u00e9decin. Libraire Universelle;1906."},{"issue":"2-3","key":"b13","series-title":"J Hist Neurosci","first-page":"334","article-title":"Eugene-Louis Doyen and his Atlas d\u2019Anatomie Topographique (1911): sensationalism and gruesome theater","volume":"31","author":"Lanska DJ","year":"2022","unstructured":"Lanska DJ. Eugene-Louis Doyen and his Atlas d\u2019Anatomie Topographique (1911): sensationalism and gruesome theater. J Hist Neurosci. 2022;31(2-3):334\u2013350. doi:10.1080\/0964704X.2022.2050643"},{"issue":"3","key":"b14","series-title":"Neurocrit Care","first-page":"724","article-title":"The legacy of Eugene-Louis Doyen: pioneer in filming craniotomy","volume":"39","author":"Wijdicks EFM","year":"2023","unstructured":"Wijdicks EFM. The legacy of Eugene-Louis Doyen: pioneer in filming craniotomy. Neurocrit Care. 2023;39(3):724\u2013727. doi:10.1007\/s12028-021-01436-5"},{"key":"b15","series-title":"French Medical Culture in the Nineteenth Century","author":"La Berge AEF","year":"1994","unstructured":"La Berge AEF, Mordechai F. French Medical Culture in the Nineteenth Century. Rodopi;1994."},{"key":"b16","series-title":"Le traitement des infections staphylococciques. Le prot\u00e9ol","author":"Doyen EL","year":"1906","unstructured":"Doyen EL. Le traitement des infections staphylococciques. Le prot\u00e9ol. Biblioth\u00e8que interuniversitaire de sant\u00e9; 1906."},{"key":"b17","series-title":"Etiologie et traitement du cancer","author":"Doyen EL","year":"1904","unstructured":"Doyen EL. Etiologie et traitement du cancer. A Maloine; 1904."},{"issue":"3","key":"b18","series-title":"J BUON","first-page":"445","article-title":"The great surgeon Eugene Doyen (1859-1916) and his disputable treatments of cancer","volume":"13","author":"Androutsos G","year":"2008","unstructured":"Androutsos G, Diamantis A, Vladimiros L. The great surgeon Eugene Doyen (1859-1916) and his disputable treatments of cancer. J BUON. 2008;13(3):445\u2013453."},{"key":"b19","series-title":"Atlas d\u2019anatomie topographique","author":"Doyen EL","year":"1911","unstructured":"Doyen EL. Atlas d\u2019anatomie topographique. A Maloine; 1911."}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/145\/5\/article-p1542.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/145\/5\/article-p1542.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/145\/5\/article-p1542.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T09:59:37Z","timestamp":1794218377000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/145\/5\/article-p1542.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11,1]]},"references-count":19,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2026.4.jns252504","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,11,1]]}}}