{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:37:57Z","timestamp":1792809477581,"version":"4.5.0"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for advanced Parkinson\u2019s disease (PD), but postoperative motor outcomes show substantial interindividual variability. Recent evidence suggests choroid plexus (ChP) dysfunction in PD pathophysiology. This study aimed to investigate the association between preoperative ChP MRI characteristics and postoperative motor outcomes following STN-DBS in PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Forty-one PD patients who underwent bilateral STN-DBS were included for final analysis. Motor outcomes were assessed using the Movement Disorder Society\u2013Unified Parkinson\u2019s Disease Rating Scale part III scores at baseline and 6 months after surgery. ChP dysfunction was evaluated by quantifying volume from T1-weighted imaging and extracting susceptibility histogram features from quantitative susceptibility mapping (QSM). Correlation and receiver operating characteristic (ROC) analyses were performed to evaluate the predictive value of ChP imaging metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Preoperative total motor scores were positively associated with maximum ChP susceptibility (r = 0.410, p = 0.008), while tremor and rigidity subscores correlated with kurtosis (r = 0.395, p = 0.011) and the 90th percentile (r = 0.356, p = 0.023), respectively, of the ChP susceptibility values. Postoperative total motor improvement showed significant positive correlations with the 10th percentile (r = 0.406, p = 0.009), mean (r = 0.325, p = 0.038), minimum (r = 0.322, p = 0.040), and skewness (r = 0.344, p = 0.028) of ChP susceptibility histogram features. For specific motor symptoms, bradykinesia improvement was positively associated with the 10th percentile (r = 0.394, p = 0.011), minimum (r = 0.335, p = 0.033), and skewness (r = 0.319, p = 0.042) of the ChP susceptibility values. Gait stability improvement correlated positively with the 10th percentile (r = 0.376, p = 0.016), mean (r = 0.379, p = 0.015), and median (r = 0.349, p = 0.026) values of ChP susceptibility. Combining ChP susceptibility histogram features with clinical characteristics achieved an area under the curve of 0.85 for differentiating superior from moderate responders to STN-DBS in terms of total motor outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This exploratory study suggests that ChP microvascular damage and iron dysregulation are linked to preoperative motor severity in PD, while ChP calcification is significantly associated with motor responsiveness to STN-DBS. Combining the susceptibility histogram features of ChP calcification with clinical characteristics may offer additional value for improving patient-specific prognostication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2026.4.jns252510","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:50Z","timestamp":1789516850000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Association between choroid plexus susceptibility features and motor outcomes following deep brain stimulation in Parkinson\u2019s disease"],"prefix":"10.3171","author":[{"given":"Siyuan","family":"Fang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai;"},{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai;"},{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luguang","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai;"},{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai;"},{"name":"Department of Radiology, Changhai Hospital, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Imaging Research & Key Laboratory of Brain-Machine Intelligence for Information Behavior (Ministry of Education and Shanghai), School of Business and Management, Shanghai International Studies University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, Changhai Hospital, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaiying","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai;"},{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai;"},{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"8","key":"b1","series-title":"Mov Disord","first-page":"1248","article-title":"International Parkinson and Movement Disorder Society evidence-based medicine review: update on treatments for the motor symptoms of Parkinson\u2019s disease","volume":"33","author":"Fox SH","year":"2018","unstructured":"Fox SH, Katzenschlager R, Lim SY,  International Parkinson and Movement Disorder Society evidence-based medicine review: update on treatments for the motor symptoms of Parkinson\u2019s disease. Mov Disord. 2018;33(8):1248\u20131266. doi:10.1002\/mds.27372"},{"issue":"S3","key":"b2","series-title":"Mov Disord","first-page":"S94","article-title":"Deep brain stimulation for Parkinson\u2019s disease: patient selection and evaluation","volume":"17","author":"Lang AE","year":"2002","unstructured":"Lang AE, Widner H. Deep brain stimulation for Parkinson\u2019s disease: patient selection and evaluation. Mov Disord. 2002;17(S3):S94\u2013S101. doi:10.1002\/mds.10149"},{"issue":"14","key":"b3","series-title":"Mov Disord","first-page":"2379","article-title":"Levodopa and subthalamic deep brain stimulation responses are not congruent","volume":"25","author":"Zaidel A","year":"2010","unstructured":"Zaidel A, Bergman H, Ritov Y, Israel Z. Levodopa and subthalamic deep brain stimulation responses are not congruent. Mov Disord. 2010;25(14):2379\u20132386. doi:10.1002\/mds.23294"},{"issue":"1","key":"b4","series-title":"Brain Commun","first-page":"fcaa005","article-title":"Differential effects of deep brain stimulation and levodopa on brain activity in Parkinson\u2019s disease","volume":"2","author":"Mueller K","year":"2020","unstructured":"Mueller K, Urgo\u0161\u00edk D, Ballarini T,  Differential effects of deep brain stimulation and levodopa on brain activity in Parkinson\u2019s disease. Brain Commun. 2020;2(1):fcaa005. doi:10.1093\/braincomms\/fcaa005"},{"issue":"5","key":"b5","series-title":"CNS Neurosci Ther","first-page":"667","article-title":"Predict initial subthalamic nucleus stimulation outcome in Parkinson\u2019s disease with brain morphology","volume":"28","author":"Chen Y","year":"2022","unstructured":"Chen Y, Zhu G, Liu Y,  Predict initial subthalamic nucleus stimulation outcome in Parkinson\u2019s disease with brain morphology. CNS Neurosci Ther. 2022;28(5):667\u2013676. doi:10.1111\/cns.13797"},{"key":"b6","series-title":"Parkinsonism Relat Disord","first-page":"17","article-title":"Cortical thickness in visuo-motor areas is related to motor outcomes after STN DBS for Parkinson\u2019s disease","volume":"71","author":"Frizon LA","year":"2020","unstructured":"Frizon LA, Gopalakrishnan R, Hogue O,  Cortical thickness in visuo-motor areas is related to motor outcomes after STN DBS for Parkinson\u2019s disease. Parkinsonism Relat Disord. 2020;71:17\u201322. doi:10.1016\/j.parkreldis.2020.01.006"},{"issue":"2","key":"b7","series-title":"J Magn Reson Imaging","first-page":"581","article-title":"Relationship between iron distribution in deep gray matter nuclei measured by quantitative susceptibility mapping and motor outcome after deep brain stimulation in patients with Parkinson\u2019s disease","volume":"58","author":"Zhao W","year":"2023","unstructured":"Zhao W, Yang C, Tong R,  Relationship between iron distribution in deep gray matter nuclei measured by quantitative susceptibility mapping and motor outcome after deep brain stimulation in patients with Parkinson\u2019s disease. J Magn Reson Imaging. 2023;58(2):581\u2013590. doi:10.1002\/jmri.28574"},{"issue":"1","key":"b8","series-title":"Ann Neurol","first-page":"67","article-title":"Connectivity predicts deep brain stimulation outcome in Parkinson disease","volume":"82","author":"Horn A","year":"2017","unstructured":"Horn A, Reich M, Vorwerk J,  Connectivity predicts deep brain stimulation outcome in Parkinson disease. Ann Neurol. 2017;82(1):67\u201378. doi:10.1002\/ana.24974"},{"issue":"1","key":"b9","series-title":"CNS Neurosci Ther","first-page":"92","article-title":"Effect of deep brain stimulation on brain network and white matter integrity in Parkinson\u2019s disease","volume":"28","author":"Huang LC","year":"2022","unstructured":"Huang LC, Chen LG, Wu PA,  Effect of deep brain stimulation on brain network and white matter integrity in Parkinson\u2019s disease. CNS Neurosci Ther. 2022;28(1):92\u2013104. doi:10.1111\/cns.13741"},{"issue":"9996","key":"b10","series-title":"Lancet","first-page":"896","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia LV","year":"2015","unstructured":"Kalia LV, Lang AE. Parkinson\u2019s disease. Lancet. 2015;386(9996):896\u2013912. doi:10.1016\/S0140-6736(14)61393-3"},{"issue":"4","key":"b11","series-title":"Neuroscientist","first-page":"364","article-title":"Neuroinflammation in Parkinson\u2019s disease: triggers, mechanisms, and immunotherapies","volume":"28","author":"Wang T","year":"2022","unstructured":"Wang T, Shi C, Luo H,  Neuroinflammation in Parkinson\u2019s disease: triggers, mechanisms, and immunotherapies. Neuroscientist. 2022;28(4):364\u2013381. doi:10.1177\/1073858421991066"},{"issue":"9","key":"b12","series-title":"Biomedicines","first-page":"2261","article-title":"The role of glymphatic system in Alzheimer\u2019s and Parkinson\u2019s disease pathogenesis","volume":"10","author":"Buccellato FR","year":"2022","unstructured":"Buccellato FR, D\u2019Anca M, Serpente M, Arighi A, Galimberti D. The role of glymphatic system in Alzheimer\u2019s and Parkinson\u2019s disease pathogenesis. Biomedicines. 2022;10(9):2261. doi:10.3390\/biomedicines10092261"},{"key":"b13","series-title":"Transl Neurodegener","first-page":"7","article-title":"Blocking meningeal lymphatic drainage aggravates Parkinson\u2019s disease-like pathology in mice overexpressing mutated \u03b1-synuclein","volume":"8","author":"Zou W","year":"2019","unstructured":"Zou W, Pu T, Feng W,  Blocking meningeal lymphatic drainage aggravates Parkinson\u2019s disease-like pathology in mice overexpressing mutated \u03b1-synuclein. Transl Neurodegener. 2019;8:7. doi:10.1186\/s40035-019-0147-y"},{"issue":"3","key":"b14","series-title":"Cells","first-page":"286","article-title":"Glymphatic system pathology and neuroinflammation as two risk factors of neurodegeneration","volume":"13","author":"Szlufik S","year":"2024","unstructured":"Szlufik S, Kope\u0107 K, Szleszkowski S, Koziorowski D. Glymphatic system pathology and neuroinflammation as two risk factors of neurodegeneration. Cells. 2024;13(3):286. doi:10.3390\/cells13030286"},{"issue":"1","key":"b15","series-title":"Annu Rev Pathol","first-page":"193","article-title":"Choroid plexus pathophysiology","volume":"20","author":"Courtney Y","year":"2025","unstructured":"Courtney Y, Hochstetler A, Lehtinen MK. Choroid plexus pathophysiology. 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Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer\u2019s and Parkinson\u2019s disease. Neurobiol Aging. 2020;89:108\u2013117. doi:10.1016\/j.neurobiolaging.2020.01.005"},{"issue":"18","key":"b19","series-title":"Cell","first-page":"4946","article-title":"The choroid plexus synergizes with immune cells during neuroinflammation","volume":"187","author":"Xu H","year":"2024","unstructured":"Xu H, Lotfy P, Gelb S,  The choroid plexus synergizes with immune cells during neuroinflammation. Cell. 2024;187(18):4946\u20134963.e17. doi:10.1016\/j.cell.2024.07.002"},{"issue":"6753","key":"b20","series-title":"Science","first-page":"eadx0043","article-title":"Neuroinflammation across neurological diseases","volume":"388","author":"Shi FD","year":"2025","unstructured":"Shi FD, Yong VW. Neuroinflammation across neurological diseases. Science. 2025;388(6753):eadx0043. doi:10.1126\/science.adx0043"},{"issue":"7","key":"b21","series-title":"AJNR Am J Neuroradiol","first-page":"776","article-title":"Choroid plexus calcification correlates with cortical microglial activation in humans: a multimodal PET, CT, MRI study","volume":"44","author":"Butler T","year":"2023","unstructured":"Butler T, Wang XH, Chiang GC,  Choroid plexus calcification correlates with cortical microglial activation in humans: a multimodal PET, CT, MRI study. AJNR Am J Neuroradiol. 2023;44(7):776\u2013782. doi:10.3174\/ajnr.A7903"},{"issue":"5","key":"b22","series-title":"J Neural Transm (Vienna)","first-page":"627","article-title":"Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson\u2019s disease","volume":"130","author":"Riederer P","year":"2023","unstructured":"Riederer P, Nagatsu T, Youdim MBH, Wulf M, Dijkstra JM, Sian-Huelsmann J. Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson\u2019s disease. J Neural Transm (Vienna). 2023;130(5):627\u2013646. doi:10.1007\/s00702-023-02630-9"},{"key":"b23","series-title":"Chin J Neurol","first-page":"541","article-title":"Chinese Expert Committee on deep brain stimulation for Parkinson\u2019s disease. Chinese expert consensus of STN-DBS for the treatment of Parkinson\u2019s disease in China","volume":"45","year":"2012","unstructured":"Chinese Expert Committee on deep brain stimulation for Parkinson\u2019s disease. Chinese expert consensus of STN-DBS for the treatment of Parkinson\u2019s disease in China. Chin J Neurol. 2012;45:541\u2013543."},{"issue":"15","key":"b24","series-title":"Mov Disord","first-page":"2129","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results","volume":"23","author":"Goetz CG","year":"2008","unstructured":"Goetz CG, Tilley BC, Shaftman SR,  Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129\u20132170. doi:10.1002\/mds.22340"},{"issue":"4","key":"b25","series-title":"J Alzheimers Dis","first-page":"1057","article-title":"Improving choroid plexus segmentation in the healthy and diseased brain: relevance for Tau-PET imaging in dementia","volume":"74","author":"Tadayon E","year":"2020","unstructured":"Tadayon E, Moret B, Sprugnoli G, Monti L, Pascual-Leone A, Santarnecchi E. 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Magn Reson Med. 2018;79(5):2795\u20132803. doi:10.1002\/mrm.26946"},{"issue":"5","key":"b27","series-title":"Brain Commun","first-page":"fcaf365","article-title":"Glymphatic dysfunction as a potential driver of cerebral iron deposition in Parkinson\u2019s disease","volume":"7","author":"Chen K","year":"2025","unstructured":"Chen K, Ji Y, Zhang L,  Glymphatic dysfunction as a potential driver of cerebral iron deposition in Parkinson\u2019s disease. Brain Commun. 2025;7(5):fcaf365. doi:10.1093\/braincomms\/fcaf365"},{"issue":"4","key":"b28","series-title":"Metab Brain Dis","first-page":"673","article-title":"Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins","volume":"24","author":"Rouault TA","year":"2009","unstructured":"Rouault TA, Zhang DL, Jeong SY. Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins. Metab Brain Dis. 2009;24(4):673\u2013684. doi:10.1007\/s11011-009-9169-y"},{"key":"b29","series-title":"Geroscience","article-title":"The impaired hemodynamics of choroid plexus and its interactions within the glymphatic system in Parkinson\u2019s disease","author":"Shang S","unstructured":"Shang S, Ding S, Xia Y,  The impaired hemodynamics of choroid plexus and its interactions within the glymphatic system in Parkinson\u2019s disease. Geroscience. Published online December 18, 2025. doi:10.1007\/s11357-025-02054-1"},{"issue":"2","key":"b30","series-title":"Radiology","first-page":"496","article-title":"Intracranial calcifications and hemorrhages: characterization with quantitative susceptibility mapping","volume":"270","author":"Chen W","year":"2014","unstructured":"Chen W, Zhu W, Kovanlikaya I,  Intracranial calcifications and hemorrhages: characterization with quantitative susceptibility mapping. Radiology. 2014;270(2):496\u2013505. doi:10.1148\/radiol.13122640"},{"issue":"4","key":"b31","series-title":"Mol Neurobiol","first-page":"2209","article-title":"Interaction between the glymphatic system and \u03b1-synuclein in Parkinson\u2019s disease","volume":"60","author":"Zhang Y","year":"2023","unstructured":"Zhang Y, Zhang C, He X-Z,  Interaction between the glymphatic system and \u03b1-synuclein in Parkinson\u2019s disease. Mol Neurobiol. 2023;60(4):2209\u20132222. doi:10.1007\/s12035-023-03212-2"},{"key":"b32","series-title":"Curr Opin Immunol","first-page":"102588","article-title":"The choroid plexus in inflammatory and degenerative diseases of the central nervous system","volume":"95","author":"Reynolds JA","year":"2025","unstructured":"Reynolds JA, Putterman C. The choroid plexus in inflammatory and degenerative diseases of the central nervous system. 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Ann Neurol. 2024;96(2):234\u2013246. doi:10.1002\/ana.26961"},{"key":"b38","series-title":"Neurobiol Dis","first-page":"106984","article-title":"Choroid plexus area and choroid plexus\/lateral ventricle area index are potential imaging markers for freezing of gait in Parkinson\u2019s disease","volume":"212","author":"Yin X","year":"2025","unstructured":"Yin X, Wang M, Zhao F,  Choroid plexus area and choroid plexus\/lateral ventricle area index are potential imaging markers for freezing of gait in Parkinson\u2019s disease. Neurobiol Dis. 2025;212:106984. doi:10.1016\/j.nbd.2025.106984"},{"key":"b39","series-title":"Transl Neurodegener","first-page":"12","article-title":"Freezing of gait in Parkinson\u2019s disease: pathophysiology, risk factors and treatments","volume":"9","author":"Gao C","year":"2020","unstructured":"Gao C, Liu J, Tan Y, Chen S. Freezing of gait in Parkinson\u2019s disease: pathophysiology, risk factors and treatments. Transl Neurodegener. 2020;9:12. doi:10.1186\/s40035-020-00191-5"},{"issue":"7","key":"b40","series-title":"J Cereb Blood Flow Metab","first-page":"1163","article-title":"Choroid plexus function in neurological homeostasis and disorders: the awakening of the circadian clocks and orexins","volume":"42","author":"Christensen J","year":"2022","unstructured":"Christensen J, Li C, Mychasiuk R. Choroid plexus function in neurological homeostasis and disorders: the awakening of the circadian clocks and orexins. J Cereb Blood Flow Metab. 2022;42(7):1163\u20131175. doi:10.1177\/0271678X221082786"},{"issue":"14","key":"b41","series-title":"Neurology","first-page":"1292","article-title":"A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD","volume":"75","author":"St George RJ","year":"2010","unstructured":"St George RJ, Nutt JG, Burchiel KJ, Horak FB. A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD. Neurology. 2010;75(14):1292\u20131299. doi:10.1212\/WNL.0b013e3181f61329"},{"key":"b42","series-title":"Front Neurosci","first-page":"731109","article-title":"Predicting motor outcome of subthalamic nucleus deep brain stimulation for Parkinson\u2019s disease using quantitative susceptibility mapping and radiomics: a pilot study","volume":"15","author":"Liu Y","year":"2021","unstructured":"Liu Y, Xiao B, Zhang C,  Predicting motor outcome of subthalamic nucleus deep brain stimulation for Parkinson\u2019s disease using quantitative susceptibility mapping and radiomics: a pilot study. 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