{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:38:06Z","timestamp":1792809486602,"version":"4.5.0"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Magnetically guided microrobots could enable minimally invasive intracranial interventions by navigating CSF spaces without traversing brain parenchyma. However, clinical translation requires in vivo validation of delivery, control, retrieval, and short-term safety under realistic workflow conditions. The aim of this study was to assess the feasibility and initial safety of percutaneous cisterna magna access, microrobot navigation, and retrieval using an image-integrated electromagnetic coil platform in a large-animal model, targeting future application to Dandy-Walker malformation cyst fenestration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this Good Laboratory Practice\u2013compliant ovine study, 7 male sheep were allocated to an MRI-only control group (n = 1), flexion control group (n = 1), and treatment group (n = 3; percutaneous cisternal access, deployment of a 3.5 \u00d7 7\u2013mm Parylene-C\u2013coated bladed microrobot with a neodymium core, magnetic navigation, scripted dwell, and retrieval), with 2 animals designated as alternates. Preoperative MRI was used for planning, with intraoperative cone-beam CT fusion and biplanar fluoroscopy. The follow-up period was 28 days and included daily observation, weekly neurological examination, and analysis of hematology\/chemistry, intraoperative CSF, and terminal necropsy with histopathology. Outcomes were descriptive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The full workflow was completed in all 3 treated animals without conversion or rescue. Cannulation succeeded on the first attempt; continuous fluoroscopic visibility and stable magnetic control were maintained; and retrieval succeeded in a single maneuver. Postoperative recovery was uneventful, with weight gain and no neurological deficits over 28 days of follow-up. Laboratory values were within reference ranges except for 1 case of transient leukocytosis (day 0) that resolved. CSF was acellular\/normal. Necropsy showed localized procedure-site changes only (dural fibrosis, thin adhesions in 2 of 3 treated animals). Histology revealed focal superficial vermian gliosis \u2264 2 mm in 2 of 3 treated animals without hemorrhage, necrosis, or off-target injury, and controls were within normal limits (1 case of minimal incidental axonal change in the flexion control).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Percutaneous cisternal delivery and retrieval of an untethered microrobot were feasible and tolerated in sheep, with localized tissue responses at 28 days. These findings support further studies focused on longer follow-up, workflow optimization, and disease-specific efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2026.4.jns252541","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:01:34Z","timestamp":1791331294000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Magnetically guided microrobot via minimally invasive percutaneous cisternal access: a first preclinical evaluation"],"prefix":"10.3171","author":[{"given":"Oana M.","family":"Mereuta","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Ognard","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota;"},{"name":"Department of Neurointervention, Univ Brest LATIM INSERM UMR 1101, Brest, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Loudon","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Children\u2019s Hospital Orange County, Orange, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esref Alperen","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota;"},{"name":"Department of Neurosurgery, Faculty of Medicine of Juntendo University, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daying","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Weissberg","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Bionaut Labs, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suehyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Bionaut Labs, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evaline","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Bionaut Labs, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Bionaut Labs, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Vaghela","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Bionaut Labs, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Bionaut Labs, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lortscher","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan R.","family":"Montonye","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Gow","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward S.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Brinjikji","sequence":"additional","affiliation":[{"name":"Department of Neurointervention, Univ Brest LATIM INSERM UMR 1101, Brest, France;"},{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanathan","family":"Kadirvel","sequence":"additional","affiliation":[{"name":"Department of Neurointervention, Univ Brest LATIM INSERM UMR 1101, Brest, France;"},{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"8","key":"b1","series-title":"Nat Rev Neurol","first-page":"443","article-title":"Paradigm changes in spine surgery: evolution of minimally invasive techniques","volume":"8","author":"Smith ZA","year":"2012","unstructured":"Smith ZA, Fessler RG. 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