{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:32:44Z","timestamp":1770355964995,"version":"3.49.0"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Diffuse midline glioma H3 K27M-mutant is a distinct subtype of glial tumors newly introduced in the revised fourth edition of the World Health Organization\n                      <jats:italic>Classification of Tumours of the Central Nervous System<\/jats:italic>\n                      . They are aggressive pediatric tumors with a poor prognosis but have also been reported in adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      The authors present the case of a man in his 60s who presented with rotatory vertigo, taste disorder, and right facial paralysis. Magnetic resonance imaging showed a tumor expanding from the cerebellum to the pons, which was histologically identified as glioblastoma, grade IV, IDH wild type. After tumor resection, the patient received chemoradiotherapy but showed only a partial response. His condition gradually worsened, and he died of progressive disease 12 months postoperation, after which an autopsy was performed. Tumor cells with a high nuclear-to-cytoplasm ratio were immunohistochemically analyzed and found to test positive for H3 K27M and negative for H3 K27me3. Furthermore, mutational analysis revealed\n                      <jats:italic>HIST1H3B<\/jats:italic>\n                      K27M mutation, and the tumor was finally identified as a high-grade glioma H3 K27M-mutant. The tumor invaded widely along the cerebral ventricle and disseminated to the spinal cord.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>When a glioblastoma shows localization or dissemination patterns different from those of typical glioblastoma, an H3 K27M-mutant glioma should be suspected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case20112","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T15:53:37Z","timestamp":1620143617000},"source":"Crossref","is-referenced-by-count":4,"title":["Cerebellar high-grade glioma with H3 K27M mutation: illustrative case"],"prefix":"10.3171","volume":"1","author":[{"given":"Mikiko","family":"Takahashi","sequence":"first","affiliation":[{"name":"Departments of Diagnostic Pathology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tomita","sequence":"additional","affiliation":[{"name":"Neurosurgery, Teikyo University Hospital, Mizonokuchi, Kawasaki, Kanagawa, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko Merrit","family":"Yamada","sequence":"additional","affiliation":[{"name":"Neurosurgery, Teikyo University Hospital, Mizonokuchi, Kawasaki, Kanagawa, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Aso","sequence":"additional","affiliation":[{"name":"Departments of Diagnostic Pathology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Departments of Diagnostic Pathology and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"WHO Classification of Tumours of the Central Nervous System","first-page":"57","article-title":"Diffuse midline glioma, H3 K27M-mutant","author":"Hawkins CE","year":"2016","unstructured":"Hawkins CE, Ellison DW, Sturm D. 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