{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:07:55Z","timestamp":1773871675174,"version":"3.50.1"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"12","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,22]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Tumors in the pineal region consist of various histological types, and correct diagnosis from biopsy specimens is sometimes difficult. The authors report the case of a patient with a mixed germ cell tumor infiltrating into the pineal gland despite showing no elevation of tumor markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>An 18-year-old man complained of headache and nausea and showed disturbance of consciousness. Magnetic resonance imaging showed hydrocephalus associated with a cystic pineal tumor. The patient underwent tumor biopsy followed by endoscopic third ventriculostomy for hydrocephalus in a local hospital. A pineocytoma was diagnosed, and the patient was referred to the authors\u2019 hospital for treatment. Concentrations of placental alkaline phosphatase, alpha-fetoprotein (AFP), and beta-human chorionic gonadotropin in cerebrospinal fluid were not elevated. However, the authors\u2019 review of the tumor specimen revealed some immature cells infiltrating the pineal gland. These cells were positive for AFP, Sal-like protein 4, and octamer-binding transcription factor 3\/4; and the diagnosis was changed to mixed germ cell tumor. Chemoradiotherapy was initiated, followed by surgical removal of the residual tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Careful examination of all tumor specimens and immunohistochemical analyses are important for accurate diagnosis of pineal tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case20131","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T12:08:22Z","timestamp":1695816502000},"source":"Crossref","is-referenced-by-count":0,"title":["Mixed germ cell tumor infiltrating the pineal gland without elevated tumor markers: illustrative case"],"prefix":"10.3171","volume":"1","author":[{"given":"Koji","family":"Shiomi","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Minamiguchi","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinori","family":"Terada","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Tanji","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Mineharu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutsugu","family":"Umeda","sequence":"additional","affiliation":[{"name":"Pediatrics, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Uto","sequence":"additional","affiliation":[{"name":"Radiation Oncology and Image-Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Takita","sequence":"additional","affiliation":[{"name":"Pediatrics, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Haga","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mizowaki","sequence":"additional","affiliation":[{"name":"Radiation Oncology and Image-Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2-3","key":"b1","series-title":"Neurochirurgie","first-page":"65","article-title":"Incidence of pineal tumours. 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