{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:48:37Z","timestamp":1770356917002,"version":"3.49.0"},"reference-count":46,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,18]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Simultaneous intracranial and testicular germ cell tumors (GCTs) are extremely rare, leading to a lack of adequate experience in their treatment. Therefore, the authors report a case of this kind of GCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 5-year-old boy was admitted to the hospital with headache and vomiting. Computed tomography and magnetic resonance imaging suggested the possibility of a GCT in the pineal region. The value of the serum tumor marker alpha-fetoprotein (AFP) was 5,396.1 \u03bcg\/L, and \u03b2-human chorionic gonadotropin levels were within the normal range. Subsequently, the tumor was removed, and the final pathological result was a mixed GCT. Therefore, chemotherapy and radiation were added. However, the authors found a testicular tumor on ultrasound at the same time, and pathology after surgery suggested a mature cystic teratoma. Following treatment, the patient recovered well, and AFP levels dropped to normal values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>To the authors\u2019 knowledge, this report is the fourth case of simultaneous intracranial and testicular GCTs and the first case of a simultaneous mixed GCT in the pineal region and mature teratoma of the testis. A combination of surgery, chemotherapy, and radiation therapy for mixed GCTs in the pineal region and surgical excision for testicular reproductive cell tumors are effective in these patients, but long-term monitoring is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case2067","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T15:32:36Z","timestamp":1611934356000},"source":"Crossref","is-referenced-by-count":3,"title":["Simultaneous intracranial and testicular germ cell tumors: illustrative case"],"prefix":"10.3171","volume":"1","author":[{"given":"Lei","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxiong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songtao","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11060-008-9640-3","article-title":"Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report","volume":"90","author":"Peltier J","year":"2008","unstructured":"Peltier J, Vinchon M, Baroncini M, . 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