{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:48:37Z","timestamp":1770356917058,"version":"3.49.0"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"26","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,28]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Eccrine porocarcinoma (EP) is a rare malignant skin neoplasm, and there are still many unknowns regarding its natural history and treatment. Due to its scarcity, associated brain metastasis is a far rarer condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 71-year-old-woman with a history of EP was diagnosed with brain metastasis. In her clinical course, the patient underwent tumor removal surgery twice and Gamma Knife radiosurgery (GKRS) four times. The tumor showed a good response to radiotherapy. The histopathological findings of the brain tumor were consistent with those of the primary skin tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>There are only a few case reports referring to the detailed treatment, especially with GKRS, of brain metastasis from EP. Few reports have presented a detailed histopathological comparison between the primary skin lesion and the metastatic brain lesion. Herein, the authors have described the clinical course, histological features, and results of multidisciplinary treatment for brain metastasis of EP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case21242","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T03:02:47Z","timestamp":1624849367000},"source":"Crossref","is-referenced-by-count":1,"title":["Management of brain metastasis from eccrine porocarcinoma: illustrative case"],"prefix":"10.3171","volume":"1","author":[{"given":"Ryuichi","family":"Noda","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Segawa","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Masuda","sequence":"additional","affiliation":[{"name":"Gamma Knife Center, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Gamma Knife Center, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuya","family":"Akabane","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"5","key":"b1","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/1097-0142(19850901)56:5<1147::AID-CNCR2820560532>3.0.CO;2-3","article-title":"Adnexal carcinomas of the skin. I. Eccrine carcinomas","volume":"56","author":"Wick MR","year":"1985","unstructured":"Wick MR, Goellner JR, Wolfe JT III, Su WP. Adnexal carcinomas of the skin. I. Eccrine carcinomas. Cancer. 1985;56(5):1147\u20131162.10.1002\/1097-0142(19850901)56:5<1147::AID-CNCR2820560532>3.0.CO;2-325275018"},{"key":"b2","series-title":"Arch Dermatol","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1001\/archderm.1963.01590230105015","article-title":"Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget\u2019s dermatosis","volume":"88","author":"Pinkus H","year":"1963","unstructured":"Pinkus H, Mehregan AH. Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget\u2019s dermatosis. Arch Dermatol. 1963;88:597\u2013606.10.1001\/archderm.1963.0159023010501525275018"},{"key":"b3","series-title":"Ann Med Surg (Lond)","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.amsu.2017.06.027","article-title":"Porocarcinoma; presentation and management, a meta-analysis of 453 cases","volume":"20","author":"Salih AM","year":"2017","unstructured":"Salih AM, Kakamad FH, Baba HO,  Porocarcinoma; presentation and management, a meta-analysis of 453 cases. Ann Med Surg (Lond). 2017;20:74\u201379.10.1016\/j.amsu.2017.06.027"},{"issue":"6","key":"b4","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1097\/00000478-200106000-00002","article-title":"Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases","volume":"25","author":"Robson A","year":"2001","unstructured":"Robson A, Greene J, Ansari N,  Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol. 2001;25(6):710\u2013720.10.1097\/00000478-200106000-00002"},{"key":"b5","series-title":"World J Surg Oncol","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1477-7819-9-32","article-title":"Metastatic eccrine porocarcinoma: report of a case and review of the literature","volume":"9","author":"Marone U","year":"2011","unstructured":"Marone U, Carac\u00f2 C, Anniciello AM,  Metastatic eccrine porocarcinoma: report of a case and review of the literature. World J Surg Oncol. 2011;9:32.10.1186\/1477-7819-9-32"},{"issue":"6","key":"b6","series-title":"Arch Dermatol","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1001\/archdermatol.2010.105","article-title":"Cutaneous appendageal carcinoma incidence and survival patterns in the United States: a population-based study","volume":"146","author":"Blake PW","year":"2010","unstructured":"Blake PW, Bradford PT, Devesa SS, Toro JR. Cutaneous appendageal carcinoma incidence and survival patterns in the United States: a population-based study. Arch Dermatol. 2010;146(6):625\u2013632.10.1001\/archdermatol.2010.105"},{"issue":"10","key":"b7","series-title":"Anticancer Res","first-page":"5263","article-title":"Chemotherapy of rare skin adnexal tumors: a review of literature","volume":"34","author":"De Iuliis F","year":"2014","unstructured":"De Iuliis F, Amoroso L, Taglieri L,  Chemotherapy of rare skin adnexal tumors: a review of literature. Anticancer Res. 2014;34(10): 5263\u20135268."},{"issue":"6","key":"b8","series-title":"Acta Derm Venereol","doi-asserted-by":"publisher","first-page":"550","DOI":"10.2340\/00015555-0310","article-title":"A case of metastatic eccrine porocarcinoma","volume":"87","author":"Kim JW","year":"2007","unstructured":"Kim JW, Oh DJ, Kang MS,  A case of metastatic eccrine porocarcinoma. Acta Derm Venereol. 2007;87(6):550\u2013552.10.2340\/00015555-0310"},{"issue":"1","key":"b9","series-title":"NPJ Precis Oncol","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41698-018-0050-5","article-title":"Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma","volume":"2","author":"Thibodeau ML","year":"2018","unstructured":"Thibodeau ML, Bonakdar M, Zhao E,  Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. NPJ Precis Oncol. 2018;2(1):8.10.1038\/s41698-018-0050-5"},{"issue":"9","key":"b10","series-title":"BMJ Case Rep","doi-asserted-by":"publisher","first-page":"e228917","DOI":"10.1136\/bcr-2018-228917","article-title":"Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab","volume":"12","author":"Lee KA","year":"2019","unstructured":"Lee KA, Cioni M, Robson A, Bataille V. Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab. BMJ Case Rep. 2019;12(9):e228917.10.1136\/bcr-2018-228917"},{"issue":"1","key":"b11","series-title":"J Clin Diagn Pathol","doi-asserted-by":"publisher","first-page":"19","DOI":"10.14302\/issn.2689-5773.jcdp-19-2890","article-title":"Transmutation of sweat glands - eccrine porocarcinoma","volume":"1","author":"Anubha B","year":"2019","unstructured":"Anubha B. Transmutation of sweat glands - eccrine porocarcinoma. J Clin Diagn Pathol. 2019;1(1):19\u201327.10.14302\/issn.2689-5773.jcdp-19-2890"},{"issue":"17","key":"b12","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1001\/jama.280.17.1485","article-title":"Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial","volume":"280","author":"Patchell RA","year":"1998","unstructured":"Patchell RA, Tibbs PA, Regine WF,  Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA. 1998;280(17):1485\u20131489.10.1001\/jama.280.17.1485"},{"issue":"33","key":"b13","series-title":"J Clin Oncol","doi-asserted-by":"publisher","first-page":"3282","DOI":"10.1200\/JCO.2018.78.6186","article-title":"Effects of surgery with salvage stereotactic radiosurgery versus surgery with whole-brain radiation therapy in patients with one to four brain metastases (JCOG0504): a phase III, noninferiority, randomized controlled trial","volume":"36","author":"Kayama T","year":"2018","unstructured":"Kayama T, Sato S, Sakurada K,  Effects of surgery with salvage stereotactic radiosurgery versus surgery with whole-brain radiation therapy in patients with one to four brain metastases (JCOG0504): a phase III, noninferiority, randomized controlled trial. J Clin Oncol. 2018;36(33):3282\u20133289.10.1200\/JCO.2018.78.6186"},{"key":"b14","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3171\/2014.7.GKS141488","article-title":"Early Gamma Knife stereotactic radiosurgery to the tumor bed of resected brain metastasis for improved local control","volume":"121","author":"Iorio-Morin C","year":"2014","unstructured":"Iorio-Morin C, Masson-C\u00f4t\u00e9 L, Ezahr Y,  Early Gamma Knife stereotactic radiosurgery to the tumor bed of resected brain metastasis for improved local control. J Neurosurg. 2014;121(suppl): 69\u201374.10.3171\/2014.7.GKS141488"},{"issue":"2","key":"b15","series-title":"Neurosurg Clin N Am","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S1042-3680(18)30189-X","article-title":"Gamma Knife radiosurgery: technology, applications, and future directions","volume":"10","author":"Yamamoto M","year":"1999","unstructured":"Yamamoto M. Gamma Knife radiosurgery: technology, applications, and future directions. Neurosurg Clin N Am. 1999;10(2):181\u2013202.10.1016\/S1042-3680(18)30189-X"},{"issue":"5","key":"b1","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/1097-0142(19850901)56:5<1147::AID-CNCR2820560532>3.0.CO;2-3","article-title":"Adnexal carcinomas of the skin. I. Eccrine carcinomas","volume":"56","author":"Wick MR","year":"1985","unstructured":"Wick MR, Goellner JR, Wolfe JT III, Su WP. Adnexal carcinomas of the skin. I. Eccrine carcinomas. Cancer. 1985;56(5):1147\u20131162.10.1002\/1097-0142(19850901)56:5<1147::AID-CNCR2820560532>3.0.CO;2-3"},{"key":"b2","series-title":"Arch Dermatol","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1001\/archderm.1963.01590230105015","article-title":"Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget\u2019s dermatosis","volume":"88","author":"Pinkus H","year":"1963","unstructured":"Pinkus H, Mehregan AH. Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget\u2019s dermatosis. Arch Dermatol. 1963;88:597\u2013606.10.1001\/archderm.1963.01590230105015"},{"key":"b3","series-title":"Ann Med Surg (Lond)","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.amsu.2017.06.027","article-title":"Porocarcinoma; presentation and management, a meta-analysis of 453 cases","volume":"20","author":"Salih AM","year":"2017","unstructured":"Salih AM, Kakamad FH, Baba HO,  Porocarcinoma; presentation and management, a meta-analysis of 453 cases. Ann Med Surg (Lond). 2017;20:74\u201379.10.1016\/j.amsu.2017.06.027"},{"issue":"6","key":"b4","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1097\/00000478-200106000-00002","article-title":"Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases","volume":"25","author":"Robson A","year":"2001","unstructured":"Robson A, Greene J, Ansari N,  Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol. 2001;25(6):710\u2013720.10.1097\/00000478-200106000-00002"},{"key":"b5","series-title":"World J Surg Oncol","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1477-7819-9-32","article-title":"Metastatic eccrine porocarcinoma: report of a case and review of the literature","volume":"9","author":"Marone U","year":"2011","unstructured":"Marone U, Carac\u00f2 C, Anniciello AM,  Metastatic eccrine porocarcinoma: report of a case and review of the literature. World J Surg Oncol. 2011;9:32.10.1186\/1477-7819-9-32"},{"issue":"6","key":"b6","series-title":"Arch Dermatol","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1001\/archdermatol.2010.105","article-title":"Cutaneous appendageal carcinoma incidence and survival patterns in the United States: a population-based study","volume":"146","author":"Blake PW","year":"2010","unstructured":"Blake PW, Bradford PT, Devesa SS, Toro JR. Cutaneous appendageal carcinoma incidence and survival patterns in the United States: a population-based study. Arch Dermatol. 2010;146(6):625\u2013632.10.1001\/archdermatol.2010.105"},{"issue":"10","key":"b7","series-title":"Anticancer Res","first-page":"5263","article-title":"Chemotherapy of rare skin adnexal tumors: a review of literature","volume":"34","author":"De Iuliis F","year":"2014","unstructured":"De Iuliis F, Amoroso L, Taglieri L,  Chemotherapy of rare skin adnexal tumors: a review of literature. Anticancer Res. 2014;34(10): 5263\u20135268."},{"issue":"6","key":"b8","series-title":"Acta Derm Venereol","doi-asserted-by":"publisher","first-page":"550","DOI":"10.2340\/00015555-0310","article-title":"A case of metastatic eccrine porocarcinoma","volume":"87","author":"Kim JW","year":"2007","unstructured":"Kim JW, Oh DJ, Kang MS,  A case of metastatic eccrine porocarcinoma. Acta Derm Venereol. 2007;87(6):550\u2013552.10.2340\/00015555-0310"},{"issue":"1","key":"b9","series-title":"NPJ Precis Oncol","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41698-018-0050-5","article-title":"Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma","volume":"2","author":"Thibodeau ML","year":"2018","unstructured":"Thibodeau ML, Bonakdar M, Zhao E,  Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. NPJ Precis Oncol. 2018;2(1):8.10.1038\/s41698-018-0050-5"},{"issue":"9","key":"b10","series-title":"BMJ Case Rep","doi-asserted-by":"publisher","first-page":"e228917","DOI":"10.1136\/bcr-2018-228917","article-title":"Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab","volume":"12","author":"Lee KA","year":"2019","unstructured":"Lee KA, Cioni M, Robson A, Bataille V. Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab. BMJ Case Rep. 2019;12(9):e228917.10.1136\/bcr-2018-228917"},{"issue":"1","key":"b11","series-title":"J Clin Diagn Pathol","doi-asserted-by":"publisher","first-page":"19","DOI":"10.14302\/issn.2689-5773.jcdp-19-2890","article-title":"Transmutation of sweat glands - eccrine porocarcinoma","volume":"1","author":"Anubha B","year":"2019","unstructured":"Anubha B. Transmutation of sweat glands - eccrine porocarcinoma. J Clin Diagn Pathol. 2019;1(1):19\u201327.10.14302\/issn.2689-5773.jcdp-19-2890"},{"issue":"17","key":"b12","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1001\/jama.280.17.1485","article-title":"Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial","volume":"280","author":"Patchell RA","year":"1998","unstructured":"Patchell RA, Tibbs PA, Regine WF,  Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA. 1998;280(17):1485\u20131489.10.1001\/jama.280.17.1485"},{"issue":"33","key":"b13","series-title":"J Clin Oncol","doi-asserted-by":"publisher","first-page":"3282","DOI":"10.1200\/JCO.2018.78.6186","article-title":"Effects of surgery with salvage stereotactic radiosurgery versus surgery with whole-brain radiation therapy in patients with one to four brain metastases (JCOG0504): a phase III, noninferiority, randomized controlled trial","volume":"36","author":"Kayama T","year":"2018","unstructured":"Kayama T, Sato S, Sakurada K,  Effects of surgery with salvage stereotactic radiosurgery versus surgery with whole-brain radiation therapy in patients with one to four brain metastases (JCOG0504): a phase III, noninferiority, randomized controlled trial. J Clin Oncol. 2018;36(33):3282\u20133289.10.1200\/JCO.2018.78.6186"},{"key":"b14","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3171\/2014.7.GKS141488","article-title":"Early Gamma Knife stereotactic radiosurgery to the tumor bed of resected brain metastasis for improved local control","volume":"121","author":"Iorio-Morin C","year":"2014","unstructured":"Iorio-Morin C, Masson-C\u00f4t\u00e9 L, Ezahr Y,  Early Gamma Knife stereotactic radiosurgery to the tumor bed of resected brain metastasis for improved local control. J Neurosurg. 2014;121(suppl): 69\u201374.10.3171\/2014.7.GKS141488"},{"issue":"2","key":"b15","series-title":"Neurosurg Clin N Am","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S1042-3680(18)30189-X","article-title":"Gamma Knife radiosurgery: technology, applications, and future directions","volume":"10","author":"Yamamoto M","year":"1999","unstructured":"Yamamoto M. Gamma Knife radiosurgery: technology, applications, and future directions. Neurosurg Clin N Am. 1999;10(2):181\u2013202.10.1016\/S1042-3680(18)30189-X"}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/1\/26\/article-CASE21242.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/1\/26\/article-CASE21242.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/1\/26\/article-CASE21242.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T14:59:32Z","timestamp":1770303572000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/1\/26\/article-CASE21242.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,28]]},"references-count":30,"journal-issue":{"issue":"26"},"URL":"https:\/\/doi.org\/10.3171\/case21242","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,28]]}}}