{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:14:34Z","timestamp":1781086474306,"version":"3.54.1"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"20","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Xanthoma is a granulomatous lesion that develops from leakage of circulating serum lipoprotein into the surrounding tissue. An isolated intracranial xanthoma is rarely reported and usually misdiagnosed. Intracranial xanthoma is also rarely found in patients with hyperlipidemia. To the best of the authors\u2019 knowledge, no previous studies and literature have reported bilateral involvement of intracranial xanthoma in the frontal lobe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors reported an unusual case of bilateral involvement of intracranial xanthoma in the frontal lobe with associated type II hyperlipidemia in a 42-year-old woman. Macroscopically, the tumor had an appearance of greyish-yellow color with a brittle, solid consistency. Histopathological examination revealed numerous lipid-laden macrophages surrounded by a cystic, necrotic, partially hemorrhagic area, with some parts consisting of hemosiderophages and proliferative capillary blood vessels. The histopathological findings indicated the characteristics of xanthoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Bilateral frontal intracranial xanthoma with associated type II hyperlipidemia is an unusual finding. Despite its rarity and wide variety of radiological presentations, it should be considered one of the differential diagnoses of lesions that develop intracranially and intraaxially. Confirmation with histopathological examination is needed to exclude from other differential diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case21465","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T02:09:40Z","timestamp":1636942180000},"source":"Crossref","is-referenced-by-count":1,"title":["Bilateral frontal intracranial xanthoma associated with type II hyperlipidemia in a 42-year-old woman: illustrative case"],"prefix":"10.3171","volume":"2","author":[{"given":"Donny","family":"Argie","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Prof. Dr. W. Z. Johannes Kupang Regional General Hospital, Kupang, East Nusa Tenggara, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Lauren","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Prof. Dr. W. Z. Johannes Kupang Regional General Hospital, Kupang, East Nusa Tenggara, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elric B.","family":"Malelak","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Prof. Dr. W. Z. Johannes Kupang Regional General Hospital, Kupang, East Nusa Tenggara, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Am J Otol","first-page":"111","article-title":"Xanthoma of the temporal bone and skull base","volume":"8","author":"Jackler RK","year":"1987","unstructured":"Jackler RK, Brackmann DE. Xanthoma of the temporal bone and skull base. Am J Otol. 1987;8(2):111\u2013115.3591917"},{"issue":"2","key":"b2","series-title":"AJNR Am J Neuroradiol","first-page":"423","article-title":"Intracranial xanthoma: long-term follow-up MR findings","volume":"27","author":"Hwang YJ","year":"2006","unstructured":"Hwang YJ, Hur G, Cha SJ, Kim YH, Kim SY, Kim MK. Intracranial xanthoma: long-term follow-up MR findings. AJNR Am J Neuroradiol. 2006;27(2):423\u2013426.16484423"},{"key":"b3","series-title":"Principles and Management of Lipid Disorders: A Primary Care Approach","doi-asserted-by":"publisher","DOI":"10.1097\/00019616-199407000-00010","author":"Oberman A","year":"1994","unstructured":"Oberman A, Kreisberg R, Henkin Y, Sawin C. Principles and Management of Lipid Disorders: A Primary Care Approach. 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