{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:13:09Z","timestamp":1789668789995,"version":"4.0.1"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"11","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,14]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Cerebrovascular events and infection are among the most common complications of left ventricular assist device (LVAD) therapy. The authors reported on a patient with an infectious intracranial aneurysm (IIA) associated with LVAD infection that was successfully occluded by endovascular therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 37-year-old man with severe heart failure received an implantable LVAD. He was diagnosed with candidemia due to driveline infection 44 months after LVAD implantation, and empirical antibiotic therapy was started. After 4 days of antibiotic treatment, the patient experienced sudden dizziness. Computed tomography (CT) revealed subarachnoid hemorrhage in the right frontal lobe, and CT angiography revealed multiple aneurysms in the peripheral lesion of the anterior cerebral artery (ACA) and middle cerebral artery. Two weeks and 4 days after the first bleeding, aneurysms on the ACA reruptured. Each aneurysm was treated with endovascular embolization using n-butyl cyanoacrylate. Subsequently, the patient had no rebleeding of IIAs. The LVAD was replaced, and bloodstream infection was controlled. He received a heart transplant and was independent 2 years after the heart transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>LVAD-associated IIAs have high mortality and an increased risk of surgical complications. However, endovascular obliteration may be safe and thus improve prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case21559","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T03:07:43Z","timestamp":1647227263000},"source":"Crossref","is-referenced-by-count":2,"title":["Endovascular therapy for intracranial infectious aneurysms associated with a left ventricular assist device: illustrative case"],"prefix":"10.3171","volume":"3","author":[{"given":"Tomohiro","family":"Okuda","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ataru","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Arimura","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuma","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Fujino","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Tanoue","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shiose","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"J Heart Lung Transplant","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.healun.2012.12.004","article-title":"Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients","volume":"32","author":"Kirklin JK","year":"2013","unstructured":"Kirklin JK, Naftel DC, Kormos RL,  Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients. J Heart Lung Transplant. 2013;32(2):141\u2013156.10.1016\/j.healun.2012.12.00428243347"},{"issue":"5","key":"b2","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1161\/STROKEAHA.117.020002","article-title":"Cerebrovascular accidents during mechanical circulatory support","volume":"49","author":"Izzy S","year":"2018","unstructured":"Izzy S, Rubin DB, Ahmed FS,  Cerebrovascular accidents during mechanical circulatory support. Stroke. 2018;49(5):1197\u20131203.10.1161\/STROKEAHA.117.020002"},{"issue":"3","key":"b3","series-title":"J Vasc Interv Neurol","first-page":"23","article-title":"Mycotic intracranial aneurysm secondary to left ventricular assist device infection","volume":"9","author":"Remirez JM","year":"2017","unstructured":"Remirez JM, Sabet Y, Baca M,  Mycotic intracranial aneurysm secondary to left ventricular assist device infection. J Vasc Interv Neurol. 2017;9(3):23\u201325.28243347"},{"issue":"1","key":"b4","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10143-009-0233-1","article-title":"Intracranial infectious aneurysms: a comprehensive review","volume":"33","author":"Ducruet AF","year":"2010","unstructured":"Ducruet AF, Hickman ZL, Zacharia BE,  Intracranial infectious aneurysms: a comprehensive review. Neurosurg Rev. 2010;33(1):37\u201346.10.1007\/s10143-009-0233-1"},{"key":"b5","series-title":"Am J Transplant","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/ajt.12126","article-title":"Ventricular assist device related infections and solid organ transplantation","volume":"13","author":"Koval CE","year":"2013","unstructured":"Koval CE, Rakita R. Ventricular assist device related infections and solid organ transplantation. Am J Transplant. 2013;13(suppl 4):348\u2013354.10.1111\/ajt.12126"},{"issue":"2","key":"b6","series-title":"J Card Fail","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.cardfail.2014.10.019","article-title":"Persistent blood stream infection in patients supported with a continuous-flow left ventricular assist device is associated with an increased risk of cerebrovascular accidents","volume":"21","author":"Trachtenberg BH","year":"2015","unstructured":"Trachtenberg BH, Cordero-Reyes AM, Aldeiri M,  Persistent blood stream infection in patients supported with a continuous-flow left ventricular assist device is associated with an increased risk of cerebrovascular accidents. J Card Fail. 2015;21(2):119\u2013125.10.1016\/j.cardfail.2014.10.019"},{"issue":"3","key":"b7","series-title":"J Artif Organs","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10047-018-1034-5","article-title":"Blood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis","volume":"21","author":"Kanjanahattakij N","year":"2018","unstructured":"Kanjanahattakij N, Horn B, Abdulhadi B, Wongjarupong N, Mezue K, Rattanawong P. Blood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis. J Artif Organs. 2018;21(3):271\u2013277.10.1007\/s10047-018-1034-5"},{"issue":"4","key":"b8","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.surneu.2006.01.021","article-title":"Different modalities of treatment of intracranial mycotic aneurysms: report of 4 cases","volume":"66","author":"Nakahara I","year":"2006","unstructured":"Nakahara I, Taha MM, Higashi T,  Different modalities of treatment of intracranial mycotic aneurysms: report of 4 cases. Surg Neurol. 2006;66(4):405\u2013410.10.1016\/j.surneu.2006.01.021"},{"key":"b9","series-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases","author":"Bennett JE","year":"2014","unstructured":"Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases. Elsevier; 2014."},{"issue":"3","key":"b10","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00234-015-1633-2","article-title":"Endovascular treatment of intracranial infectious aneurysms","volume":"58","author":"Esenkaya A","year":"2016","unstructured":"Esenkaya A, Duzgun F, Cinar C,  Endovascular treatment of intracranial infectious aneurysms. Neuroradiology. 2016;58(3):277\u2013284.10.1007\/s00234-015-1633-2"},{"issue":"25","key":"b11","series-title":"Blood","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1182\/blood-2015-10-636480","article-title":"Acquired von Willebrand syndrome associated with left ventricular assist device","volume":"127","author":"Nascimbene A","year":"2016","unstructured":"Nascimbene A, Neelamegham S, Frazier OH, Moake JL, Dong JF. Acquired von Willebrand syndrome associated with left ventricular assist device. Blood. 2016;127(25):3133\u20133141.10.1182\/blood-2015-10-636480"},{"issue":"1-2","key":"b12","series-title":"Intervent Neurol","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1159\/000455806","article-title":"Endovascular embolization of intracranial infectious aneurysms in patients undergoing open heart surgery using n-butyl cyanoacrylate","volume":"6","author":"Cheng-Ching E","year":"2017","unstructured":"Cheng-Ching E, John S, Bain M,  Endovascular embolization of intracranial infectious aneurysms in patients undergoing open heart surgery using n-butyl cyanoacrylate. Intervent Neurol. 2017;6(1-2):82\u201389.10.1159\/000455806"},{"issue":"2","key":"b1","series-title":"J Heart Lung Transplant","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.healun.2012.12.004","article-title":"Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients","volume":"32","author":"Kirklin JK","year":"2013","unstructured":"Kirklin JK, Naftel DC, Kormos RL,  Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients. J Heart Lung Transplant. 2013;32(2):141\u2013156.10.1016\/j.healun.2012.12.004"},{"issue":"5","key":"b2","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1161\/STROKEAHA.117.020002","article-title":"Cerebrovascular accidents during mechanical circulatory support","volume":"49","author":"Izzy S","year":"2018","unstructured":"Izzy S, Rubin DB, Ahmed FS,  Cerebrovascular accidents during mechanical circulatory support. Stroke. 2018;49(5):1197\u20131203.10.1161\/STROKEAHA.117.020002"},{"issue":"3","key":"b3","series-title":"J Vasc Interv Neurol","first-page":"23","article-title":"Mycotic intracranial aneurysm secondary to left ventricular assist device infection","volume":"9","author":"Remirez JM","year":"2017","unstructured":"Remirez JM, Sabet Y, Baca M,  Mycotic intracranial aneurysm secondary to left ventricular assist device infection. J Vasc Interv Neurol. 2017;9(3):23\u201325."},{"issue":"1","key":"b4","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10143-009-0233-1","article-title":"Intracranial infectious aneurysms: a comprehensive review","volume":"33","author":"Ducruet AF","year":"2010","unstructured":"Ducruet AF, Hickman ZL, Zacharia BE,  Intracranial infectious aneurysms: a comprehensive review. Neurosurg Rev. 2010;33(1):37\u201346.10.1007\/s10143-009-0233-1"},{"key":"b5","series-title":"Am J Transplant","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/ajt.12126","article-title":"Ventricular assist device related infections and solid organ transplantation","volume":"13","author":"Koval CE","year":"2013","unstructured":"Koval CE, Rakita R. Ventricular assist device related infections and solid organ transplantation. Am J Transplant. 2013;13(suppl 4):348\u2013354.10.1111\/ajt.12126"},{"issue":"2","key":"b6","series-title":"J Card Fail","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.cardfail.2014.10.019","article-title":"Persistent blood stream infection in patients supported with a continuous-flow left ventricular assist device is associated with an increased risk of cerebrovascular accidents","volume":"21","author":"Trachtenberg BH","year":"2015","unstructured":"Trachtenberg BH, Cordero-Reyes AM, Aldeiri M,  Persistent blood stream infection in patients supported with a continuous-flow left ventricular assist device is associated with an increased risk of cerebrovascular accidents. J Card Fail. 2015;21(2):119\u2013125.10.1016\/j.cardfail.2014.10.019"},{"issue":"3","key":"b7","series-title":"J Artif Organs","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10047-018-1034-5","article-title":"Blood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis","volume":"21","author":"Kanjanahattakij N","year":"2018","unstructured":"Kanjanahattakij N, Horn B, Abdulhadi B, Wongjarupong N, Mezue K, Rattanawong P. Blood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis. J Artif Organs. 2018;21(3):271\u2013277.10.1007\/s10047-018-1034-5"},{"issue":"4","key":"b8","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.surneu.2006.01.021","article-title":"Different modalities of treatment of intracranial mycotic aneurysms: report of 4 cases","volume":"66","author":"Nakahara I","year":"2006","unstructured":"Nakahara I, Taha MM, Higashi T,  Different modalities of treatment of intracranial mycotic aneurysms: report of 4 cases. Surg Neurol. 2006;66(4):405\u2013410.10.1016\/j.surneu.2006.01.021"},{"key":"b9","series-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases","author":"Bennett JE","year":"2014","unstructured":"Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases. Elsevier; 2014."},{"issue":"3","key":"b10","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00234-015-1633-2","article-title":"Endovascular treatment of intracranial infectious aneurysms","volume":"58","author":"Esenkaya A","year":"2016","unstructured":"Esenkaya A, Duzgun F, Cinar C,  Endovascular treatment of intracranial infectious aneurysms. Neuroradiology. 2016;58(3):277\u2013284.10.1007\/s00234-015-1633-2"},{"issue":"25","key":"b11","series-title":"Blood","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1182\/blood-2015-10-636480","article-title":"Acquired von Willebrand syndrome associated with left ventricular assist device","volume":"127","author":"Nascimbene A","year":"2016","unstructured":"Nascimbene A, Neelamegham S, Frazier OH, Moake JL, Dong JF. Acquired von Willebrand syndrome associated with left ventricular assist device. Blood. 2016;127(25):3133\u20133141.10.1182\/blood-2015-10-636480"},{"issue":"1-2","key":"b12","series-title":"Intervent Neurol","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1159\/000455806","article-title":"Endovascular embolization of intracranial infectious aneurysms in patients undergoing open heart surgery using n-butyl cyanoacrylate","volume":"6","author":"Cheng-Ching E","year":"2017","unstructured":"Cheng-Ching E, John S, Bain M,  Endovascular embolization of intracranial infectious aneurysms in patients undergoing open heart surgery using n-butyl cyanoacrylate. Intervent Neurol. 2017;6(1-2):82\u201389.10.1159\/000455806"}],"container-title":["Journal of Neurosurgery: Case Lessons"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/3\/11\/article-CASE21559.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/3\/11\/article-CASE21559.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-case-lessons\/3\/11\/article-CASE21559.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T14:45:04Z","timestamp":1770302704000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-case-lessons\/3\/11\/article-CASE21559.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,14]]},"references-count":24,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.3171\/case21559","relation":{},"ISSN":["2694-1902"],"issn-type":[{"value":"2694-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,14]]}}}