{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:31:58Z","timestamp":1770352318987,"version":"3.49.0"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"12","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,21]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Primary intramedullary spinal cord (IMSC) pilocytic astrocytoma (PA) with anaplasia is extremely rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 50-year-old man presented to our hospital with numbness of the left posterior rib region, back, and bilateral lower limbs. Contrast-enhanced T1-weighted magnetic resonance imaging (MRI) revealed an intramedullary lesion at T2\u2013T3 with no contrast enhancement. The patient opted for conservative treatment. Eighteen months after the first consultation, the patient presented with slowly progressive numbness of the bilateral upper limbs, paraparesis, and dysuria, with rapid deterioration over the following 3 months. T1- and T2-weighted MRI revealed expansion of the intramedullary lesion, which extended from C7 to T5, and syringomyelia at C5\u2013C6. Contrast-enhanced T1-weighted MRI revealed an enhancing intramedullary lesion at C7\u2013T5. Open biopsy and C5\u2013T5 laminectomy were performed for diagnosis and decompression. PA with anaplasia was diagnosed based on pathological and immunohistochemical findings. The patient received postoperative radiotherapy and chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Rapidly progressive IMSC PA with a change in contrast enhancement is extremely rare in adults. PA may undergo a spontaneous malignant transformation during its natural clinical course. In this case, the change in contrast enhancement may have been associated with the malignant transformation of the PA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case21702","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T03:07:41Z","timestamp":1647832061000},"source":"Crossref","is-referenced-by-count":2,"title":["Primary intramedullary spinal cord pilocytic astrocytoma with anaplasia in an adult: illustrative case"],"prefix":"10.3171","volume":"3","author":[{"given":"Toshinari","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Otsu City Hospital, Otsu, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Otsu City Hospital, Otsu, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Otsu City Hospital, Otsu, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hikari Hospital, Otsu, Shiga, Japan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Shirahata","sequence":"additional","affiliation":[{"name":"Departments of Neuro-Oncology\/Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Departments of Neuro-Oncology\/Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Homma","sequence":"additional","affiliation":[{"name":"Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Ioroi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Otsu City Hospital, Otsu, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E14","DOI":"10.3171\/2015.5.FOCUS15158","article-title":"Intramedullary spinal cord tumors: a review of current and future treatment strategies","volume":"39","author":"Tobin MK","year":"2015","unstructured":"Tobin MK, Geraghty JR, Engelhard HH, Linninger AA, Mehta AI. 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