{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:05:47Z","timestamp":1785812747482,"version":"3.56.0"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"22","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,31]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Alveolar echinococcosis is a rare condition, but living or working in a rural environment is a substantial risk factor. The liver is the organ primarily affected, with additional extrahepatic manifestations in approximately 25% of cases. Primary extrahepatic disease is rare, and isolated cerebral involvement is extremely unusual.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors described an illustrative case of isolated cerebral alveolar echinococcosis in an immunocompetent farmer. Magnetic resonance imaging of the brain showed a predominantly cystic lesion with perifocal edema and a \u201cbunch of grapes\u201d appearance in the left frontal lobe. Histology revealed sharply demarcated fragments of a fibrous cyst wall accompanied by marked inflammation and necrosis. Higher magnification showed remnants of protoscolices with hooklets and calcified corpuscles. Immunohistochemistry and polymerase chain reaction (PCR) analysis confirmed the diagnosis of cerebral alveolar echinococcosis. Interestingly, serology and thoracic and abdominal computed tomography results were negative, indicative of an isolated primary extrahepatic manifestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Isolated, primary central nervous system echinococcosis is extremely rare, with only isolated case reports. As in the authors\u2019 case, it can occur in immunocompetent patients, especially persons with a rural vocational history. Negative serology results do not exclude cerebral echinococcosis, which requires histological confirmation. Immunohistochemical staining and PCR analysis are especially useful in cases without classic morphological findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case2187","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T03:02:47Z","timestamp":1622430167000},"source":"Crossref","is-referenced-by-count":5,"title":["An immunocompetent farmer with isolated cerebral alveolar echinococcosis: illustrative case"],"prefix":"10.3171","volume":"1","author":[{"given":"Anna Maria","family":"Reuss","sequence":"first","affiliation":[{"name":"Departments of Neuropathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Angela","family":"Wulf","sequence":"additional","affiliation":[{"name":"Departments of Neuropathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F.","family":"Oertel","sequence":"additional","affiliation":[{"name":"Surgical Pathology;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Bozinov","sequence":"additional","affiliation":[{"name":"Surgical Pathology;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Henzi","sequence":"additional","affiliation":[{"name":"Departments of Neuropathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa B.","family":"Kaelin","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Reinehr","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Grimm","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, University Hospital Zurich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth J.","family":"Rushing","sequence":"additional","affiliation":[{"name":"Departments of Neuropathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"36","key":"b1","series-title":"Swiss Med Forum","doi-asserted-by":"publisher","first-page":"760","DOI":"10.4414\/smf.2017.03046","article-title":"Die alveol\u00e4re Echinokokkose","volume":"17","author":"Beldi G","year":"2017","unstructured":"Beldi G, M\u00fcller N, Gottstein B. 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