{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:41:06Z","timestamp":1770352866578,"version":"3.49.0"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,25]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Primary intracranial rhabdomyosarcoma is an extraordinarily rare malignant tumor, with even fewer presenting with distant metastasis. To date, only five cases, including the one presented here, have been reported to present metastatic activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>A 12-year-old boy presented with a few days of headache, nausea, vomiting, but no neurological deficit. Brain computed tomography and magnetic resonance imaging demonstrated hydrocephalus and a cystic lesion with left parieto-occipital extension. After resection, pathology reported primary rhabdomyosarcoma, with positive desmin and myogenin on immunohistochemistry. The patient presented with pulmonary metastasis. The patient had an overall survival of 21 months after diagnosis with optimal treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>Rhabdomyosarcoma is a malignant neoplasm arising from undifferentiated skeletal muscle cells, with morphological, immunohistochemical, ultrastructural, or molecular genetic evidence of primary skeletal muscle differentiation. It presents with a rapidly worsening clinical course and the final outcome is poor. Treatment is widely based on protocols that have been proven to be effective in extracranial versions of these tumors, although repeatedly ineffective. Primary brain rhabdomyosarcoma poses a diagnostic challenge because of its infrequent presentation, grade of undifferentiation and tumor heterogeneity. Immunohistochemical and genetic testing have proven to be useful tools for diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case22189","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:05:58Z","timestamp":1659326758000},"source":"Crossref","is-referenced-by-count":0,"title":["Metastatic primary brain rhabdomyosarcoma in a pediatric patient: illustrative case"],"prefix":"10.3171","volume":"4","author":[{"given":"Michel Gustavo","family":"Mondrag\u00f3n-Soto","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Del Valle","sequence":"additional","affiliation":[{"name":"Molecular Histopathology & Microscopy Core, Stanley S. Scott Cancer Center Louisiana State University Health, New Orleans, Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alfredo","family":"Gonz\u00e1lez-Soto","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma Metropolitana, Mexico City, Mexico; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Alfonso","family":"De Leo-Vargas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, ABC Neurological Center, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.wneu.2018.05.054","article-title":"Primary intracranial rhabdomyosarcoma in the cerebellopontine angle resected after preoperative embolization","volume":"116","author":"Yoshida K","year":"2018","unstructured":"Yoshida K, Miwa T, Akiyama T, Nishimoto M, Kamamoto D, Yoshida K. 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