{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:28:53Z","timestamp":1770352133407,"version":"3.49.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,16]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      spp. are strictly anaerobic microorganisms and normal flora of the oropharyngeal, gastrointestinal, and female genital tracts. It is commonly associated with periodontal disease, pharyngitis, mastoiditis, and tonsillitis, with a tendency to abscess formation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      The authors report a case of brain abscesses complicated by ventriculitis and obstructive hydrocephalus caused by\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                      of suspected odontogenic source. While repeated bacterial cultures remained negative, the isolate was identified using bacterial sequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>\n                      Empirical antimicrobial coverage for\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                      should be considered in patients presenting with brain abscess. Genetic bacterial sequencing utilizing 16S ribosomal RNA molecular diagnostic testing may assist in microorganism identification to guide antimicrobial therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case22195","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T03:06:25Z","timestamp":1673838385000},"source":"Crossref","is-referenced-by-count":3,"title":["Ruptured intraventricular brain abscesses due to Fusobacterium nucleatum with obstructive hydrocephalus: illustrative case"],"prefix":"10.3171","volume":"5","author":[{"given":"Nina","family":"Srour","sequence":"first","affiliation":[{"name":"Departments of Pharmacy Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Demand","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Houston Methodist Neurological Institute, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Musick","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Lista","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiejian","family":"Lin","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Houston Methodist Hospital, Houston, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Clin Microbiol Rev","first-page":"55","article-title":"Taxonomy, biology, and periodontal aspects of Fusobacterium nucleatum","volume":"9","author":"Bolstad AI","year":"1996","unstructured":"Bolstad AI, Jensen HB, Bakken V. Taxonomy, biology, and periodontal aspects of Fusobacterium nucleatum. Clin Microbiol Rev. 1996;9(1):55\u201371.8665477"},{"issue":"4","key":"b2","series-title":"Infection","first-page":"475","article-title":"Fusobacterium nucleatum infections: clinical spectrum and bacteriological features of 78 cases","volume":"44","author":"Denes E","year":"2016","unstructured":"Denes E, Barraud O. Fusobacterium nucleatum infections: clinical spectrum and bacteriological features of 78 cases. Infection. 2016;44(4):475\u2013481.26783023"},{"issue":"1","key":"b3","series-title":"Jpn J Infect Dis","first-page":"40","article-title":"Clinical characteristics of fusobacterial brain abscess","volume":"60","author":"Hsieh MJ","year":"2007","unstructured":"Hsieh MJ, Chang WN, Lui CC,  Clinical characteristics of fusobacterial brain abscess. Jpn J Infect Dis. 2007;60(1):40\u201344.17314424"},{"key":"b4","series-title":"Interdiscip Neurosurg","first-page":"101062","article-title":"Fusobacterium nucleatum and brain abscess: case report and literature review","volume":"24","author":"Chaovarin C","year":"2021","unstructured":"Chaovarin C, Polpong P, Sungkhachat O. Fusobacterium nucleatum and brain abscess: case report and literature review. Interdiscip Neurosurg. 2021;24:101062."},{"issue":"Pt 5","key":"b5","series-title":"J Med Microbiol","first-page":"668","article-title":"A rare presentation of ventriculitis and brain abscess caused by Fusobacterium nucleatum","volume":"57","author":"Kai A","year":"2008","unstructured":"Kai A, Cooke F, Antoun N, Siddharthan C, Sule O. A rare presentation of ventriculitis and brain abscess caused by Fusobacterium nucleatum. 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Jpn J Infect Dis. 2007;60(1):40\u201344.17314424"},{"key":"b4","series-title":"Interdiscip Neurosurg","first-page":"101062","article-title":"Fusobacterium nucleatum and brain abscess: case report and literature review","volume":"24","author":"Chaovarin C","year":"2021","unstructured":"Chaovarin C, Polpong P, Sungkhachat O. Fusobacterium nucleatum and brain abscess: case report and literature review. Interdiscip Neurosurg. 2021;24:101062."},{"issue":"Pt 5","key":"b5","series-title":"J Med Microbiol","first-page":"668","article-title":"A rare presentation of ventriculitis and brain abscess caused by Fusobacterium nucleatum","volume":"57","author":"Kai A","year":"2008","unstructured":"Kai A, Cooke F, Antoun N, Siddharthan C, Sule O. A rare presentation of ventriculitis and brain abscess caused by Fusobacterium nucleatum. 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