{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T01:36:21Z","timestamp":1777253781776,"version":"3.51.4"},"reference-count":62,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,16]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Pituitary carcinoma is a rare tumor of the adenohypophysis with noncontiguous craniospinal dissemination and\/or systemic metastases. Given the rarity of this malignancy, there is limited knowledge and consensus regarding its natural history, prognosis, and optimal treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>The authors present the case of a 46-year-old woman initially treated with invasive prolactin-secreting pituitary macroadenoma who developed metastatic disease of the cervical spine 6 years later. The patient presented with acutely worsening compressive cervical myelopathy and required posterior cervical decompression, tumor resection, and instrumented arthrodesis for posterolateral fusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>This case underscores the importance of long-term monitoring of hormone levels and having a high clinical suspicion for metastatic disease to the spine in patients presenting with acute myelopathy or radiculopathy in the setting of previously treated invasive secreting pituitary adenoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case22363","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T03:06:25Z","timestamp":1673838385000},"source":"Crossref","is-referenced-by-count":1,"title":["Natural history of pituitary carcinoma with metastasis to the cervical spine: illustrative case"],"prefix":"10.3171","volume":"5","author":[{"given":"Nicholas T.","family":"Gamboa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Wilkerson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bornali","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon A.","family":"Sherrod","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Dailey","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Couldwell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Neurosurg Rev","first-page":"279","article-title":"Invasive adenoma and pituitary carcinoma: a SEER database analysis","volume":"37","author":"Hansen TM","year":"2014","unstructured":"Hansen TM, Batra S, Lim M,  Invasive adenoma and pituitary carcinoma: a SEER database analysis. Neurosurg Rev. 2014;37(2):279\u2013286.24526366"},{"issue":"2","key":"b2","series-title":"Eur J Endocrinol","first-page":"203","article-title":"Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry","volume":"156","author":"Saeger W","year":"2007","unstructured":"Saeger W, L\u00fcdecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S. Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol. 2007;156(2):203\u2013216.17287410"},{"issue":"1","key":"b3","series-title":"Pituitary","first-page":"201","article-title":"Epidemiology of common and uncommon adult pituitary tumors in the U.S. according to the 2017 World Health Organization classification","volume":"25","author":"Castellanos LE","year":"2022","unstructured":"Castellanos LE, Gutierrez C, Smith T, Laws ER, Iorgulescu JB. Epidemiology of common and uncommon adult pituitary tumors in the U.S. according to the 2017 World Health Organization classification. Pituitary. 2022;25(1):201\u2013209."},{"issue":"2","key":"b4","series-title":"J Neurol Surg B Skull Base","first-page":"180","article-title":"A population-level analysis of pituitary carcinoma from the National Cancer Database","volume":"81","author":"Carey RM","year":"2020","unstructured":"Carey RM, Kuan EC, Workman AD,  A population-level analysis of pituitary carcinoma from the National Cancer Database. J Neurol Surg B Skull Base. 2020;81(2):180\u2013186.32206537"},{"issue":"4","key":"b5","series-title":"Cancer","first-page":"804","article-title":"Pituitary carcinoma: a clinicopathologic study of 15 cases","volume":"79","author":"Pernicone PJ","year":"1997","unstructured":"Pernicone PJ, Scheithauer BW, Sebo TJ,  Pituitary carcinoma: a clinicopathologic study of 15 cases. 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