{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:47:27Z","timestamp":1770353247366,"version":"3.49.0"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,16]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Blastomyces dermatitidis<\/jats:italic>\n                      is a fungus endemic to central and southern North America. While infection most commonly results in pneumonia, a small number of infections progress to systemic disease, which may include intracranial lesions. Progression to systemic disease is most common in immunocompromised patients, such as those with human immunodeficiency virus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      The authors present a 44-year-old immunocompetent male who presented following a tonic-clonic seizure. Initial workup revealed a 19-mm enhancing intracranial mass. There was avid uptake of fluorescein sodium, and an en bloc resection of the mass was performed. Histopathology revealed\n                      <jats:italic>B. dermatitidis.<\/jats:italic>\n                      Medical management included amphotericin B and azole therapy. Postoperative recovery was uneventful, and no focal neurological deficits were appreciated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>\n                      This case highlights the neurosurgical management of a rare intracranial fungal manifestation in an immunocompetent patient. A literature review was also performed to better understand the role of neurosurgery in fungal infections. There were limited cases of intracranial\n                      <jats:italic>Blastomyces<\/jats:italic>\n                      reported in immunocompetent patients, and neurosurgical management varied (no intervention, biopsy, resection) and was underreported. Too few cases are reported to suggest neurosurgical intervention for blastomycosis improves outcomes. Medical management was relatively standard with azole and amphotericin therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case22406","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T03:06:25Z","timestamp":1673838385000},"source":"Crossref","is-referenced-by-count":0,"title":["Disseminated blastomycosis with an intracranial fungoma in an immunocompetent patient: illustrative case"],"prefix":"10.3171","volume":"5","author":[{"given":"Annabelle","family":"Shaffer","sequence":"first","affiliation":[{"name":"Carle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, Illinois; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Johnson","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Guglielmi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anant","family":"Naik","sequence":"additional","affiliation":[{"name":"Carle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, Illinois; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Najafali","sequence":"additional","affiliation":[{"name":"Carle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, Illinois; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Carle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, Illinois; and"},{"name":"Infectious Diseases, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Bellafiore","sequence":"additional","affiliation":[{"name":"Pathology, Carle Foundation Hospital, Urbana, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Carle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, Illinois; and"},{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Hassaneen","sequence":"additional","affiliation":[{"name":"Carle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, Illinois; and"},{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Infect Dis Clin North Am","first-page":"247","article-title":"Blastomycosis","volume":"30","author":"Castillo CG","year":"2016","unstructured":"Castillo CG, Kauffman CA, Miceli MH. Blastomycosis. Infect Dis Clin North Am. 2016;30(1):247\u2013264.26739607"},{"issue":"28","key":"b2","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"601","article-title":"Blastomycosis\u2014Wisconsin, 1986\u20131995","volume":"45","year":"1996","unstructured":"Centers for Disease Control and Prevention (CDC). Blastomycosis\u2014Wisconsin, 1986\u20131995. MMWR Morb Mortal Wkly Rep. 1996; 45(28):601\u2013603.8676851"},{"issue":"2","key":"b3","series-title":"Diagn Microbiol Infect Dis","first-page":"175","article-title":"Outcomes of persons with blastomycosis involving the central nervous system","volume":"76","author":"Bush JW","year":"2013","unstructured":"Bush JW, Wuerz T, Embil JM, Del Bigio MR, McDonald PJ, Krawitz S. Outcomes of persons with blastomycosis involving the central nervous system. 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