{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:56:45Z","timestamp":1770353805719,"version":"3.49.0"},"reference-count":70,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"10","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Choroid plexus carcinoma (CPC) is a rare, primarily intraventricular neoplasm. Extent of resection correlates with improved outcomes but is limited due to tumor vascularity and size. Evidence on optimal surgical management and molecular drivers of recurrence remains limited. Here the authors characterize a case of multiply recurrent CPC treated with sequential endoscopic removals over 10 years and highlight its genomic properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      Five years after standard treatment, a 16-year-old female presented with a distant intraventricular recurrence of CPC. Whole exome sequencing revealed\n                      <jats:italic>NF1<\/jats:italic>\n                      ,\n                      <jats:italic>PER1<\/jats:italic>\n                      , and\n                      <jats:italic>SLC12A2<\/jats:italic>\n                      mutations,\n                      <jats:italic>FGFR3<\/jats:italic>\n                      gain, and no\n                      <jats:italic>TP53<\/jats:italic>\n                      alterations. Repeat sequencing on recurrences 4 and 5 years later showed persistent\n                      <jats:italic>NF1<\/jats:italic>\n                      and\n                      <jats:italic>FGFR3<\/jats:italic>\n                      alterations. Methylation profiling was consistent with plexus tumor, subclass pediatric B. Short-term magnetic resonance imaging detected four total isolated recurrences, all treated with complete endoscopic resections at 5, 6.5, 9, and 10 years after initial diagnosis. Mean hospital stay for all recurrences was 1 day with no complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>\n                      The authors describe a patient with four isolated recurrences of CPC over a decade, each treated with complete endoscopic removal, and identify unique molecular alterations that persisted without\n                      <jats:italic>TP53<\/jats:italic>\n                      alterations. These outcomes support frequent neuroimaging to facilitate endoscopic surgical removal following early detection of CPC recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case22508","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T08:10:45Z","timestamp":1678090245000},"source":"Crossref","is-referenced-by-count":0,"title":["Durability of an endoscopic management strategy for recurrent choroid plexus carcinoma with a comprehensive molecular characterization: illustrative case"],"prefix":"10.3171","volume":"5","author":[{"given":"Sergio W.","family":"Guadix","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler S.","family":"Garman","sequence":"additional","affiliation":[{"name":"Brady Urological Institute & Department of Urology, Johns Hopkins University, Baltimore, Maryland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carson","family":"Gundlach","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Pisapia","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Souweidane","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery, and"},{"name":"Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neuro Oncol","first-page":"v1","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009-2013","volume":"18","author":"Ostrom QT","year":"2016","unstructured":"Ostrom QT, Gittleman H, Xu J,  CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009-2013. Neuro Oncol. 2016;18(suppl 5):v1\u2013v75.28475809"},{"issue":"2","key":"b2","series-title":"Neurosurg Rev","first-page":"179","article-title":"Current management of choroid plexus carcinomas","volume":"37","author":"Sun MZ","year":"2014","unstructured":"Sun MZ, Oh MC, Ivan ME,  Current management of choroid plexus carcinomas. Neurosurg Rev. 2014;37(2):179\u2013192, discussion 192.24068529"},{"issue":"1","key":"b3","series-title":"J Neurooncol","first-page":"179","article-title":"Gross total resection improves overall survival in children with choroid plexus carcinoma","volume":"116","author":"Sun MZ","year":"2014","unstructured":"Sun MZ, Ivan ME, Clark AJ,  Gross total resection improves overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014;116(1):179\u2013185.24166581"},{"issue":"2","key":"b4","series-title":"J Neurooncol","first-page":"353","article-title":"Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma","volume":"120","author":"Sun MZ","year":"2014","unstructured":"Sun MZ, Ivan ME, Oh MC,  Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014;120(2):353\u2013360.25106865"},{"issue":"2","key":"b5","series-title":"J Neurosurg Pediatr","first-page":"126","article-title":"Neoadjuvant chemotherapy reduces blood loss during the resection of pediatric choroid plexus carcinomas","volume":"16","author":"Schneider C","year":"2015","unstructured":"Schneider C, Kamaly-Asl I, Ramaswamy V,  Neoadjuvant chemotherapy reduces blood loss during the resection of pediatric choroid plexus carcinomas. 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