{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:38:38Z","timestamp":1778103518517,"version":"3.51.4"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,24]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Tuberculosis is an airborne disease caused by\n                      <jats:italic>Mycobacterium tuberculosis.<\/jats:italic>\n                      Intracranial tuberculoma is a rare complication of extrapulmonary tuberculosis due to hematogenous spread to subpial and subependymal regions. Intracranial tuberculoma can occur with or without meningitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBSERVATIONS<\/jats:title>\n                    <jats:p>\n                      A 3-year-old male who had recently emigrated from Sudan presented to the emergency department with right-sided seizures lasting 30 minutes, which were aborted with levetiracetam and midazolam. Head computed tomography revealed a multilobulated left supratentorial mass with solid and cystic components and measuring 8.0 \u00d7 4.8 \u00d7 6.5 cm. The patient had successful resection of the mass, which was positive for\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      . He was started on rifampin, isoniazid, pyrazinamide, ethambutol, and fluoroquinolone and was discharged home in stable condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LESSONS<\/jats:title>\n                    <jats:p>A literature review on pediatric intracranial tuberculoma was performed, which included 48 studies (n = 49). The mean age was 8.8 \u00b1 5.4 years with a slight female predilection (59%). Predominant solitary tuberculomas (63%) were preferentially managed with both resection and antituberculosis therapy (ATT), whereas multifocal tuberculomas were preferentially managed with ATT. Intracranial tuberculoma is a rare but treatable cause of space-occupying lesions in children. Clinicians should maintain a high level of suspicion in patients from endemic regions and involve the infectious disease service early.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/case23236","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T09:53:58Z","timestamp":1690278838000},"source":"Crossref","is-referenced-by-count":3,"title":["Pediatric intracranial tuberculoma: illustrative case"],"prefix":"10.3171","volume":"6","author":[{"given":"Eva","family":"Liu","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramath","family":"Kakodkar","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Pan","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Zhou","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Toyota","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit Rahul","family":"Persad","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Marciniuk","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland Nikolaus","family":"Auer","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Sanche","sequence":"additional","affiliation":[{"name":"Infectious Disease, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksander","family":"Vitali","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Radic","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Afr Health Sci","first-page":"116","article-title":"Central nervous system tuberculosis","volume":"11","author":"Cherian A","year":"2011","unstructured":"Cherian A, Thomas SV. 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